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  4. Recombinant Human N-terminal kinase-like protein (SCYL1), partial

Recombinant Human N-terminal kinase-like protein (SCYL1), partial

  • 中文名稱：
    人SCYL1重組蛋白
  • 貨號：
    CSB-YP839356HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SCYL1重組蛋白
  • 貨號：
    CSB-EP839356HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SCYL1重組蛋白
  • 貨號：
    CSB-EP839356HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SCYL1重組蛋白
  • 貨號：
    CSB-BP839356HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SCYL1重組蛋白
  • 貨號：
    CSB-MP839356HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SCYL1
  • Uniprot No.：
  • 別名：
    Coated vesicle associated kinase of 90 kDa; Coated vesicle-associated kinase of 90 kDa; CVAK90; GKLP; HT019; Likely ortholog of mouse N terminal kinase like protein ; MGC78454; N terminal kinase like; N terminal kinase like protein; N-terminal kinase-like protein; NKTL; NTKL; NTKL_HUMAN; NTKLBP1; P105; SCY L1; SCY1 like 1; SCY1 like 1 protein 1; SCY1-like protein 1; SCYL 1; Scyl1; SCYL1BP1; TAPK; TEIF; Telomerase regulation associated protein; Telomerase regulation-associated protein; Telomerase transcriptional element interacting factor ; Telomerase transcriptional element-interacting factor; Teratoma associated tyrosine kinase ; Teratoma-associated tyrosine kinase; TRAP
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro.; Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.
  • 基因功能參考文獻：
    1. findings indicate that SCYL1 does not contribute to REST turnover and thus do not support a previous study suggesting a role for SCYL1 in mediating REST degradation PMID: 28570664
    2. Disruptive SCYL1 mutations underlie a syndrome characterized by recurrent episodes of liver failure, peripheral neuropathy, cerebellar atrophy, and ataxia. PMID: 26581903
    3. Data identified the large GTPase dynamin2 as an interacting protein of NTKL, which might be responsible for the phenotype alterations caused by NTKL overexpression, such as cytokinesis failure, increased cell motility and abnormal of cell division. PMID: 25575811
    4. Data reveal that Scyl1 is a key organizer of a subset of the COPI machinery. PMID: 24481816
    5. TEIF is a downstream effector in EGF/PI3K/Akt signaling. PMID: 24769208
    6. TEIF as a novel MSP58-interacting protein. PMID: 24361335
    7. suggested that the interaction of SCYL1BP1/Pirh2 could accelerate Pirh2 degradation through an ubiquitin-dependent pathway. SCYL1BP1 may function as an important tumor suppressor gene in HCC development PMID: 22570270
    8. TEIF protein and centrosome amplification is commonly found in colorectal tumors. The expression level of TEIF is related to tumor histological grade and malignant degree. PMID: 19958622
    9. Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology PMID: 20209057
    10. Scyl1 participates in the nuclear aminoacylation-dependent tRNA export pathway. PMID: 20505071
    11. SCYL1-BP1 can be ubiquitinated and degraded by Pirh2 but not by MDM2, which suggests that SCYL1-BP1 can be regulated by Pirh2. PMID: 20598683
    12. NTKL is involved in centrosome-related cellular functions PMID: 12036289
    13. Molecular cloning of telomerase transcriptional elements-interacting factor,(TEIF). TEIF may take part in the transcriptional activation of hTERT. PMID: 15504359
    14. TEIF could specifically activate transcription of beta-pol promoter, but not that of DNA polymerase alpha or delta promoter. The responsible sequences for binding of TEIF were revealed PMID: 15963946
    15. TEIF functions as a centrosome regulator. Its participation in DNA damage response, including telomere dysfunction and tumorigenesis. PMID: 19198626

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  • 相關疾病：
    Spinocerebellar ataxia, autosomal recessive, 21 (SCAR21)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.; [Isoform 1]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.; [Isoform 2]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.; [Isoform 3]: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.; [Isoform 6]: Nucleus.
  • 蛋白家族：
    Protein kinase superfamily
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 14372

    OMIM: 607982

    KEGG: hsa:57410

    STRING: 9606.ENSP00000270176

    UniGene: Hs.238839



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