在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Myotubularin-related protein 6 (MTMR6)

  • 中文名稱:
    人MTMR6重組蛋白
  • 貨號:
    CSB-YP897519HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人MTMR6重組蛋白
  • 貨號:
    CSB-EP897519HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人MTMR6重組蛋白
  • 貨號:
    CSB-EP897519HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人MTMR6重組蛋白
  • 貨號:
    CSB-BP897519HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人MTMR6重組蛋白
  • 貨號:
    CSB-MP897519HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    4022440C11Rik; AI428804; AU041072; MGC27983; MTMR 6; Mtmr6; MTMR6_HUMAN; Myotubularin related protein 6; Myotubularin-related protein 6; RP11-271M24.1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-621
  • 氨基酸序列
    MEHIRTTKVE QVKLLDRFST SNKSLTGTLY LTATHLLFID SHQKETWILH HHIASVEKLA LTTSGCPLVI QCKNFRTVHF IVPRERDCHD IYNSLLQLSK QAKYEDLYAF SYNPKQNDSE RLQGWQLIDL AEEYKRMGVP NSHWQLSDAN RDYKICETYP RELYVPRIAS KPIIVGSSKF RSKGRFPVLS YYHQDKEAAI CRCSQPLSGF SARCLEDEHL LQAISKANPV NRYMYVMDTR PKLNAMANRA AGKGYENEDN YSNIRFQFVG IENIHVMRSS LQKLLEVNGT KGLSVNDFYS GLESSGWLRH IKAVMDAAIF LAKAITVENA SVLVHCSDGW DRTSQVCSLG SLLLDSYYRT IKGFMVLIEK DWISFGHKFS ERCGQLDGDP KEVSPVFTQF LECVWHLTEQ FPQAFEFSEA FLLQIHEHIH SCQFGNFLGN CQKEREELKL KEKTYSLWPF LLEDQKKYLN PLYSSESHRF TVLEPNTVSF NFKFWRNMYH QFDRTLHPRQ SVFNIIMNMN EQNKQLEKDI KDLESKIKQR KNKQTDGILT KELLHSVHPE SPNLKTSLCF KEQTLLPVND ALRTIEGSSP ADNRYSEYAE EFSKSEPAVV SLEYGVARMT C
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels.
  • 基因功能參考文獻:
    1. MTMR6, which dephosphorylates PI(3)P to PI, and its binding partner MTMR9, are required for macropinocytosis. PMID: 24591580
    2. results indicate that the cellular localization of MTMR6 is regulated by Rab1B in the early secretory and autophagic pathways PMID: 23188820
    3. investigation of MTM1 and MTMR6 and finding that they use PtdIns(3,5)P2 in addition to PtdIns3P as a substrate in vitro PMID: 12646134
    4. Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. PMID: 12847286
    5. Data show that KCa3.1, which is critical for Ca2+ influx in reactivated naive T cells and central memory T cells, requires phosphatidylinositol-3 phosphatase for activation and is inhibited by PI(3)P phosphatase myotubularin-related protein 6 (MTMR6). PMID: 16847315
    6. MTMR9 greatly enhances the functions of MTMR6 PMID: 19038970

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
  • 組織特異性:
    Expressed in CD4+ T-cells.
  • 數據庫鏈接:

    HGNC: 7453

    OMIM: 603561

    KEGG: hsa:9107

    STRING: 9606.ENSP00000371221

    UniGene: Hs.643702



主站蜘蛛池模板: 欧美真人性做爰全过程| 性一交一乱一伦一| 国产精品午夜剧场免费观看| 天天摸天天做天天爽水多| 国产成人精品a视频| 97人洗澡人人澡人人爽人人模| 亚洲卡一卡二卡三新区乱码| 夜夜躁狠狠躁日日躁视频| 国产手机在线αⅴ片无码观看| 怡春院国产精品视频| 狠狠做久久深爱婷婷| 99精品视频在线观看免费蜜桃| 51国偷自产一区二区三区| 女人被狂躁c到高潮喷水电影| 欧美三級片黃色三級片黃色| 老湿机国产福利视频| 国产美女精品中文网蜜芽宝贝 | 少妇仑乱a毛片| 日本妇人成熟免费| 日韩卡1卡2 卡三卡免费| 亚洲s久久久久一区二区| 欧美激情视频一区二区三区免费| 久99久无码精品视频免费播放| 中文字幕乱码久久午夜不卡| 国产成人啪精品午夜网站a片免费 国产精品人妻久久久久 | 午夜香蕉成视频人网站| 色诱视频在线观看| 美女裸体自慰在线观看| 国产公妇仑乱在线观看| 2020精品国产自在现线官网| 性生交大片免费看女人按摩| 在线看片无码永久av| 中文字幕v亚洲日本在线电影| 66lu国产在线观看| 欧美午夜精品久久久久久浪潮| 亚洲精品无码你懂的| 中国免费看的片| 国产96在线 | 欧美| 丁香五月激情综合国产| 加勒比东京热无码一区| 久久久久久久久久久国产|