在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MTMR6 Antibody, HRP conjugated

MTMR6 Antibody, HRP conjugated

  • 中文名稱：
    MTMR6兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA897519LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MTMR6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    4022440C11Rik antibody; AI428804 antibody; AU041072 antibody; MGC27983 antibody; MTMR 6 antibody; Mtmr6 antibody; MTMR6_HUMAN antibody; Myotubularin related protein 6 antibody; Myotubularin-related protein 6 antibody; RP11-271M24.1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Myotubularin-related protein 6 protein (1-260AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels.
  • 基因功能參考文獻(xiàn)：
    1. MTMR6, which dephosphorylates PI(3)P to PI, and its binding partner MTMR9, are required for macropinocytosis. PMID: 24591580
    2. results indicate that the cellular localization of MTMR6 is regulated by Rab1B in the early secretory and autophagic pathways PMID: 23188820
    3. investigation of MTM1 and MTMR6 and finding that they use PtdIns(3,5)P2 in addition to PtdIns3P as a substrate in vitro PMID: 12646134
    4. Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. PMID: 12847286
    5. Data show that KCa3.1, which is critical for Ca2+ influx in reactivated naive T cells and central memory T cells, requires phosphatidylinositol-3 phosphatase for activation and is inhibited by PI(3)P phosphatase myotubularin-related protein 6 (MTMR6). PMID: 16847315
    6. MTMR9 greatly enhances the functions of MTMR6 PMID: 19038970

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
  • 組織特異性：
    Expressed in CD4+ T-cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7453

    OMIM: 603561

    KEGG: hsa:9107

    STRING: 9606.ENSP00000371221

    UniGene: Hs.643702



主站蜘蛛池模板： 天堂网在线最新版www中文网| 国产精品成人免费999| 精品国产一区二区三区香蕉| 国产在视频线精品视频| 久久久老熟女一区二区三区| 丁香五月激情综合色婷婷| 99久久无色码中文字幕人妻蜜柚| 久久青草成人综合网站| 国产综合一区二区三区黄页秋霞| 久久精品娱乐亚洲领先| 天堂а√在线中文在线最新版| 无码 制服 丝袜 国产 另类| 日本三级成本人网站| 在线看片免费人成视频福利| 亚洲韩国日本高清一区| 国产超碰人人做人人爽av大片| 人妻无码中文专区久久五月婷| 国精产品一品二品国精在线观看| 色悠久久久久久久综合网伊人| 国产亚洲精品久久久久5区| 国产成人美女裸体片免费看| 人妻无码熟妇乱又伦精品视频| 国模吧无码一区二区三区| 美女张开腿让男人桶爽| 日产精品高潮呻吟av久久| 狠狠色丁香五月综合缴情婷婷五月| 成人国产一区二区三区精品| 国产综合无码一区二区色蜜蜜| 国产三级久久久精品麻豆三级| 亚洲中文字幕日产无码成人片| 老汉色老汉首页a亚洲| 国产卡1卡2卡3麻豆精品免费 | 国产妇女馒头高清泬20p多| 一本一本久久a久久精品综合| 亚洲久久中文字幕www网站| 日本真人边吃奶边做爽动态图| 亚洲乱码中文字幕综合234| 中文字幕人妻丝袜二区| 国产精品成人va在线观看| 亚洲va无码va在线va天堂| av国産精品毛片一区二区视频|