在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Monoacylglycerol lipase ABHD12 (ABHD12), partial

Recombinant Human Monoacylglycerol lipase ABHD12 (ABHD12), partial

  • 中文名稱：
    Recombinant Human Monoacylglycerol lipase ABHD12(ABHD12),partial
  • 貨號：
    CSB-YP839785HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Monoacylglycerol lipase ABHD12(ABHD12),partial
  • 貨號：
    CSB-EP839785HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Monoacylglycerol lipase ABHD12(ABHD12),partial
  • 貨號：
    CSB-EP839785HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Monoacylglycerol lipase ABHD12(ABHD12),partial
  • 貨號：
    CSB-BP839785HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Monoacylglycerol lipase ABHD12(ABHD12),partial
  • 貨號：
    CSB-MP839785HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ABHD12
  • Uniprot No.：
  • 別名：
    2-arachidonoylglycerol hydrolase; 6330583M11Rik; ABD12_HUMAN; ABHD12; ABHD12A; Abhydrolase domain containing protein 12; Abhydrolase domain-containing protein 12; AI431047; AW547313; BEM46L2; C20orf22; Monoacylglycerol lipase ABHD12; RP23-241M12.2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding.
  • 基因功能參考文獻：
    1. This study presented the various mutation of ABHD12 responsible for PHARC syndrome. PMID: 28448692
    2. Study identified a new missense mutation, p.T253R, in ABHD12, which is functionally linked to the neurodegenerative disease PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and early-onset cataract), as demonstrated by its deactivation of monoacylglycerol lipase activity and inability to rescue zebrafish abhd12 knockdown phenotypes. PMID: 27890673
    3. ABHD12 mutation in 2 PHARC (Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract)patients who suffered from deaf-blindness and dysfunctional central and peripheral nervous systems. PMID: 25743180
    4. Null mutations in the ABHD12 gene lead to PHARC syndrome, a neurodegenerative disease including polyneuropathy, hearing loss, cerebellar ataxia, RP, and early-onset cataract. Our study allowed us to report 5 new mutations in ABHD12. PMID: 24697911
    5. This is the first report of compound heterozygosity in PHARC and the first study to describe how a mutation might affect ABHD12 expression and function. PMID: 24027063
    6. ABHD12 mutations are not a frequent cause of ataxia at least in Southern Italy PMID: 23490117
    7. After the identification of the ABHD12 mutation in this family, one patient underwent neurological examination which revealed ataxia, but no polyneuropathy PMID: 22938382
    8. Data show that the three hydrolases are genuine MAG lipases; medium-chain saturated MAGs were the best substrates for hABHD6 and hMAGL, whereas hABHD12 preferred the 1 (3)- and 2-isomers of arachidonoylglycerol. PMID: 22969151
    9. Mutations in the ABHD12 gene cause polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract disease. PMID: 20797687

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract (PHARC)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    Serine esterase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15868

    OMIM: 612674

    KEGG: hsa:26090

    STRING: 9606.ENSP00000365725

    UniGene: Hs.441550



主站蜘蛛池模板： 无尺码精品产品国产| 成人性生交大片免费看小说| 免费看又黄又爽又猛的视频软件| 欧美一性一乱一交一免费视频| 久久久国产精品麻豆a片| 东京热人妻中文无码av| 欧美猛少妇色xxxxx猛叫| 青青青国产在线观看资源| 视频二区丝袜国产欧美日韩| 精品成人av一区二区三区| 亚洲乱码精品久久久久..| 色综合网天天综合色中文| 丰满人妻无码∧v区视频| 日本无遮挡吸乳视频| 精品久久久久久无码人妻| 国内精品久久久久影院蜜芽 | 国产精品爽爽va吃奶在线观看| 久久精品九九热无码免贵| 黑人糟蹋人妻hd中文字幕| 国产精品亚洲二区在线播放| 大伊香蕉精品视频在线直播| 日日噜噜夜夜狠狠va视频v| 无码少妇一区二区三区芒果| 国语对白做受xxxxx在| 少妇愉情理伦片bd| 亚洲成av人片久久| 亚洲精品色情aⅴ色戒| 西西人体www44rt大胆高清| 人人妻人人澡人人爽人人精品电影| 真人祼交二十三式视频| 欧美国产伦久久久久久久| 国产精品亚亚洲欧关中字幕 | 欧美亚洲另类 丝袜综合网| 国产精品青草久久福利不卡| 乱妇乱女熟妇熟女网站| 亚洲欧美中文日韩v日本| 国产未成女一区二区| 无码毛片内射白浆视频| 国产亚洲精品久久久久久久软件| 久拍国产在线观看| 狠狠色狠狠色综合网|