在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ABHD12 Antibody

  • 中文名稱:
    ABHD12兔多克隆抗體
  • 貨號:
    CSB-PA022733
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA022733(ABHD12 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA022733(ABHD12 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ABHD12
  • 別名:
    2-arachidonoylglycerol hydrolase antibody; 6330583M11Rik antibody; ABD12_HUMAN antibody; ABHD12 antibody; ABHD12A antibody; Abhydrolase domain containing protein 12 antibody; Abhydrolase domain-containing protein 12 antibody; AI431047 antibody; AW547313 antibody; BEM46L2 antibody; C20orf22 antibody; Monoacylglycerol lipase ABHD12 antibody; RP23-241M12.2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human ABHD12
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding.
  • 基因功能參考文獻:
    1. This study presented the various mutation of ABHD12 responsible for PHARC syndrome. PMID: 28448692
    2. Study identified a new missense mutation, p.T253R, in ABHD12, which is functionally linked to the neurodegenerative disease PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and early-onset cataract), as demonstrated by its deactivation of monoacylglycerol lipase activity and inability to rescue zebrafish abhd12 knockdown phenotypes. PMID: 27890673
    3. ABHD12 mutation in 2 PHARC (Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract)patients who suffered from deaf-blindness and dysfunctional central and peripheral nervous systems. PMID: 25743180
    4. Null mutations in the ABHD12 gene lead to PHARC syndrome, a neurodegenerative disease including polyneuropathy, hearing loss, cerebellar ataxia, RP, and early-onset cataract. Our study allowed us to report 5 new mutations in ABHD12. PMID: 24697911
    5. This is the first report of compound heterozygosity in PHARC and the first study to describe how a mutation might affect ABHD12 expression and function. PMID: 24027063
    6. ABHD12 mutations are not a frequent cause of ataxia at least in Southern Italy PMID: 23490117
    7. After the identification of the ABHD12 mutation in this family, one patient underwent neurological examination which revealed ataxia, but no polyneuropathy PMID: 22938382
    8. Data show that the three hydrolases are genuine MAG lipases; medium-chain saturated MAGs were the best substrates for hABHD6 and hMAGL, whereas hABHD12 preferred the 1 (3)- and 2-isomers of arachidonoylglycerol. PMID: 22969151
    9. Mutations in the ABHD12 gene cause polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract disease. PMID: 20797687

    顯示更多

    收起更多

  • 相關疾病:
    Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract (PHARC)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族:
    Serine esterase family
  • 數據庫鏈接:

    HGNC: 15868

    OMIM: 612674

    KEGG: hsa:26090

    STRING: 9606.ENSP00000365725

    UniGene: Hs.441550



主站蜘蛛池模板: www成人国产高清内射| 中文日韩亚洲欧美制服| 麻豆国产精品va在线观看| 中文字幕丰满伦子无码| 日韩少妇激情一区二区| 国精产品一区一区三区免费视频| 天美麻花果冻视频大全英文版| 日日澡夜夜澡人人高潮| 欧美最猛黑人xxxx黑人猛交| 国产成人精品久久一区二区| 亚洲精品少妇一区二区| 中文无码一区二区三区在线观看| 波多野结衣办公室双飞| 亚洲欧美一区二区三区| 久久精品私人影院免费看| 精品国产成人高清在线观看 | 成人亚洲一区无码久久| 国产精品人妻在线观看| 色妞www精品视频| 搡8o老女人老妇人老熟| 欧洲美女黑人粗性暴交视频| 免费观看国产小粉嫩喷水| 亚洲久久久久久中文字幕| 国产成人久久av免费高潮| 免费裸体黄网站18禁免费| 久久综合狠狠综合久久综| av性色在线乱叫| 成人动漫综合网| 国产精品香蕉在线的人| 真人做人60分钟啪啪免费看| 亚洲欧美成人一区二区在线| 人妻精品久久久久中文字幕69| 亚洲精品久久无码av片| 亚洲中文字幕永久在线全国| 日本亚州视频在线八a| 国产大片黄在线观看| 韩国三级在线观看久| 日韩高清成片免费视频| 成年无码动漫av片在线尤物网站| 亚洲成av人影院| 日韩av高清在线观看|