在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Mitochondrial proton/calcium exchanger protein (LETM1), partial

Recombinant Human Mitochondrial proton/calcium exchanger protein (LETM1), partial

  • 中文名稱：
    人LETM1重組蛋白
  • 貨號：
    CSB-YP012877HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人LETM1重組蛋白
  • 貨號：
    CSB-EP012877HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人LETM1重組蛋白
  • 貨號：
    CSB-EP012877HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LETM1重組蛋白
  • 貨號：
    CSB-BP012877HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LETM1重組蛋白
  • 貨號：
    CSB-MP012877HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    LETM1
  • Uniprot No.：
  • 別名：
    LETM1; Mitochondrial proton/calcium exchanger protein; Leucine zipper-EF-hand-containing transmembrane protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion.
  • 基因功能參考文獻：
    1. these results revealed that the knockdown of LETM1 exhibited tumor suppressive effects, possibly by controlling the downstream Wnt/beta-catenin signaling pathway. PMID: 29048663
    2. Data indicate a positive association between LETM1 up-regulation, YAP1 nuclear localization and high PDGFB expression. PMID: 27556512
    3. LETM1 plays an important role in the progression of breast cancer PMID: 26722481
    4. LETM1 protein overexpression is associated with Triple negative breast cancer progression, and may be a potential biomarker for poor prognostic evaluation of Triple negative breast cancer. PMID: 25617527
    5. LETM1 plays an important role in the progression of head and neck squamous cell carcinoma. PMID: 24689060
    6. Letm1 expression is decreased in patients with intractable TLE and a rat model of epilepsy. Down-regulation of Letm1 leads to increases mitochondrial swelling and decreased MT-CYB expression, which is associated with susceptibility to seizures. PMID: 23645710
    7. Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2+) transport and bioenergetics PMID: 25077561
    8. These findings identify novel cellular phenotypes in Wolf-Hirschhorn syndrome attributable to a 50% reduction in LETM1 expression level. PMID: 24626991
    9. Haploinsufficiency of WHSC1 and/or LETM1 contributes to Wolf-Hirschhorn Syndrome, but that loss of distinct and/or additional genes in 4p16.3 is necessary for the expression of the core Wolf-Hirschhorn Syndrome phenotype. PMID: 23963300
    10. NCLX, but not LETM1, mediates Ca(2+) extrusion from mitochondria. By controlling the duration of matrix Ca(2+) elevations, NCLX contributes to the regulation of NAD(P)H production and to the conversion of Ca(2+) signals into redox changes. PMID: 24898248
    11. Functional properties of Letm1 described in study are remarkably similar to those of the H(+)-dependent Ca(2+) transport mechanism identified in intact mitochondria. PMID: 24344246
    12. Data indicate that loss of Letm1 contributes to the pathology of Wolf-Hirschhorn syndrome and may contribute to seizure phenotypes by reducing glucose oxidation and other specific metabolic alterations. PMID: 23716663
    13. Summarizes the current state of the art about the functions of LETM1 and its role in pathophysiology, with some emphasis on whether it is a feasible candidate for regulation of mitochondrial Ca2+ homeostasis. PMID: 22641639
    14. Letm1 and UCP2/3 independently contribute to two distinct, mitochondrial Ca(2+) uptake pathways in intact endothelial cells. PMID: 21613221
    15. we have identified a novel submicroscopic duplication involving dosage sensitive genes TACC3, FGFR3, and LETM1. PMID: 21815251
    16. LETM1 suppressed lung cancer cell growth in vitro and in vivo. PMID: 20824095
    17. LETM1 is evolutionarily conserved throughout the eukaryotic kingdom and located in the mitochondria. PMID: 14706454
    18. Here, we present cellular and biochemical analysis of Letm1 PMID: 17606466
    19. Study shows that human LETM1 is located in the inner membrane, exposed to the matrix and oligomerized in higher molecular weight complexes of unknown composition; down-regulation of LETM1 caused 'necrosis-like' death, without activation of caspases. PMID: 17925330
    20. the LETM1-mediated regulation of the mitochondrial volume and its interaction with the mitochondrial AAA-ATPase BCS1L that is responsible for three different human disorders PMID: 18628306
    21. LETM1 protein is a novel binding partner for Carboxyl-terminal modulator protein that may play an important role in mitochondrial fragmentation via optic atrophy type 1-cleavage. PMID: 19168126
    22. Data suggest that LETM1 serves as an anchor protein for complex formation with the mitochondrial ribosome and regulates mitochondrial biogenesis. Increased expression of LETM1 in human cancer suggests that dysregulation of LETM1 features in tumorigenesis. PMID: 19318571
    23. Letm1, was found to specifically mediate coupled Ca2+/H+ exchange; RNAi knockdown, overexpression, and liposome reconstitution of the purified Letm1 protein demonstrate that Letm1 is a mitochondrial Ca2+/H+ antiporter PMID: 19797662

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    LETM1 family
  • 數據庫鏈接：

    HGNC: 6556

    OMIM: 604407

    KEGG: hsa:3954

    STRING: 9606.ENSP00000305653

    UniGene: Hs.120165



主站蜘蛛池模板： 狠狠精品久久久无码中文字幕 | 粗大猛烈进出高潮视频免费看| 51视频国产精品一区二区| 免费香蕉成视频人网站| 四虎www永久在线精品| 精品无码国产污污污免费| 少妇真实被内射视频三四区| 正在播放的国产a一片| 鲁一鲁一鲁一鲁一曰综合网| 国产老妇伦国产熟女老妇高清 | 亚洲一卡2卡3卡4卡 精品 | 亚洲久热中文字幕在线| 体验区试看120秒啪啪免费| 久草热久草热线频97精品| 久久久亚洲欧洲日产国码aⅴ| 久久久无码精品亚洲日韩蜜桃| 国产精品综合一区二区三区| 欧美成人性做爰77777| 亚洲日本在线电影| 我的公把我弄高潮了视频 | 亚洲亚洲人成无码网www| 亚洲自偷自拍另类11p| 国内揄拍高清国内精品对白| 青青青国产精品国产精品美女 | 精选国产av精选一区二区三区| 欧美激情综合五月色丁香| 久久久久女人精品毛片| 亚洲一区天堂九一| 国产乱子伦一区二区三区=| 国产情侣久久久久aⅴ免费| 国产精品高清视亚洲中文| 亚洲中文字幕无码卡通动漫野外| 男男又爽又黄又无遮挡网站| 野外少妇愉情中文字幕| 西西444www无码大胆| 国产av亚洲精品ai换脸电影| 亚洲欧美日韩一区二区| 国产色在线 | 亚洲| 少妇白浆呻吟爽| 人人狠狠综合久久亚洲爱咲| 亚洲人成无码网站久久99热国产|