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  4. Recombinant Human Microtubule-associated protein 1B (MAP1B), partial

Recombinant Human Microtubule-associated protein 1B (MAP1B), partial

  • 中文名稱：
    人MAP1B重組蛋白
  • 貨號：
    CSB-YP013401HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MAP1B重組蛋白
  • 貨號：
    CSB-EP013401HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MAP1B重組蛋白
  • 貨號：
    CSB-EP013401HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MAP1B重組蛋白
  • 貨號：
    CSB-BP013401HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MAP1B重組蛋白
  • 貨號：
    CSB-MP013401HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MAP1B
  • Uniprot No.：
  • 別名：
    FUTSCH; LC1; MAP-1B; MAP1 light chain LC1; Map1b; MAP1B_HUMAN; MAP5; Microtubule associated protein 1B; Mtap1b; Mtap5
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.
  • 基因功能參考文獻：
    1. All of the patients with a microtubule associated protein 1B (MAP1B) variant had a similar brain abnormality, and at least one of the parents who transmitted the variant to their child was also similarly affected. PMID: 29738522
    2. MAP1B heavy chain has a unique binding site for a calcium-binding protein ALG-2. PMID: 29432744
    3. These results suggest that a change in the intracellular calcium level plays a role in regulation of the secretory pathway via interaction of ALG-2 with MISSL and MAP1B. PMID: 28864773
    4. The found of this study suggested that possible roles of MAP1B genes in working memory performance in ADHD patients PMID: 26233433
    5. KIRREL3 interacting proteins MAP1B and MYO16 are potential candidates for intellectual disability and autism spectrum disorder. PMID: 25902260
    6. signal transduction pathways downstream of 5-HT6R are regulated by MAP1B, which might play a role in 5-HT6R-mediated signaling in the brain. PMID: 24614691
    7. The the MAP1B-LC1-mediated regulation most likely involves an internalization of the channels via a dynamin and clathrin-dependent pathway. PMID: 25483588
    8. An interaction between MAP1B LC1 and the ubiquitin-conjugating enzyme UBE2L3. PMID: 24566975
    9. Localization of MAP1B is altered in amyotrophic lateral sclerosis spinal cords in a transgenic animal model. PMID: 25429138
    10. Yeast-two-hybrid screening using human LRRK2 kinase domain as bait identified microtubule associated protein 1B (MAP1B) as a LRRK2 interactor. PMID: 24754922
    11. We suggest a role for Stau2 in the generation and regulation of Map1b mRNA containing granules that are required for mGluR-long-term depression PMID: 21508097
    12. These observations define a new and crucial function of MAP1B that is required for efficient cross-talk between microtubules and the actin cytoskeleton during neuronal polarization. PMID: 20719958
    13. MAP1B action is modulated by mapmodulin/leucine-rich acidic nuclear protein PMID: 12807913
    14. The light chain (LC1) of microtubule-associated protein 1B (MAP1B)-5-HT(3A) receptor interaction contributes to a mechanism that regulates receptor desensitization kinetics. PMID: 18063656
    15. Amyloid-beta 1-42 binds to a peptide comprising the microtubule binding domain of the heavy chain of microtubule-associated protein 1B by the screening of a human brain cDNA library expressed on M13 phage. PMID: 18079022
    16. a role for MAP1B in DAPK-1-dependent signaling in autophagy and membrane blebbing. PMID: 18195017
    17. MAP1B light chain can interact with the tumor suppressor p53. PMID: 18656471
    18. a new protein involved in the terminal differentiation of odontoblasts PMID: 19567321

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, synapse. Cell projection, dendritic spine.; [MAP1 light chain LC1]: Cytoplasm.
  • 蛋白家族：
    MAP1 family
  • 數據庫鏈接：

    HGNC: 6836

    OMIM: 157129

    KEGG: hsa:4131

    STRING: 9606.ENSP00000296755

    UniGene: Hs.335079



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