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  4. Recombinant Human Metabotropic glutamate receptor 7 (GRM7), partial

Recombinant Human Metabotropic glutamate receptor 7 (GRM7), partial

  • 中文名稱：
    人GRM7重組蛋白
  • 貨號：
    CSB-YP618911HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GRM7重組蛋白
  • 貨號：
    CSB-EP618911HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GRM7重組蛋白
  • 貨號：
    CSB-EP618911HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GRM7重組蛋白
  • 貨號：
    CSB-BP618911HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GRM7重組蛋白
  • 貨號：
    CSB-MP618911HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    FLJ40498; GLUR7; Glutamate receptor metabotropic 7; GPRC1G; GRM7; GRM7_HUMAN; Metabotropic glutamate receptor 7; MGLU7; mGluR7; OTTHUMP00000206961; OTTHUMP00000214674; OTTHUMP00000214675
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits.
  • 基因功能參考文獻：
    1. The mutant allele C in rs1485175 of the GMR7 may decrease individuals' susceptibility to noise-induced hearing loss. PMID: 29301492
    2. The results of this study indicate that the GRM7 rs9814881 might be associated with MDD in the Chinese Han population. PMID: 28027116
    3. study to evaluate evidence for association between GRM7 and alcohol behaviors using an SNP approach, as well as a gene-based approach in two independent samples; Rs3749380 was suggestively associated with alcohol consumption in one sample with the minor T allele conferring risk; there was no evidence for association in the other sample PMID: 27788777
    4. Autism spectrum disorder (ASD) as a synaptopathy is revealed to be pertained to aberrant glutamatergic neurotransmission. Glutamate receptor, metabotropic 7 (GRM7) is a receptor coding gene of this pathway. PMID: 27312574
    5. GRM7 rs2133450 may have translational relevance as a predictor of response to risperidone in schizophrenia. PMID: 26856250
    6. Multiple genetic models identified 1 significant locus, GRM7, for 2 hypertension-derived traits. PMID: 26866891
    7. Study represents a genetic association test towards single variant and multi-markers interaction of GRM7 and GRM8 genes in both schizophrenia and major depressive disorders in Han Chinese population PMID: 26655190
    8. Glutamate system genes have been associated with disease risk in recent analyses from the Psychiatric Genomics Consortium. PMID: 26905411
    9. results indicate that the GRM7 SNPs rs13353402 and rs1531939 might be associated with schizophrenia in Chinese Han population. PMID: 26254163
    10. results reported here do not support a role for GRM7 in ADHD PMID: 25360607
    11. Copy number variants at GRM7 may have a role in the etiology of bipolar disorder. PMID: 24804643
    12. For neither PCLO nor GRM7 we found a more associated variant. For SLC6A4, we found a new SNP that showed a lower P-value than in the GAIN-MDD GWAS PMID: 24278217
    13. in an elderly male Han Chinese population, GRM7 SNP rs11928865 (TT) occurs more frequently in age-related hearing impairment patients with SL and AL phenotype patterns. PMID: 24146964
    14. These results provide preliminary evidence of an association between the GRM7 rs37952452 polymorphism and selective attention deficit and anxiety found within the Korean ADHD population PMID: 23295062
    15. Mixed modeling analyses explored the relationship of GRM7 haplotype and SNP genotypes with measures of auditory perception. GRM7 alleles are associated primarily with peripheral measures of hearing loss, and with speech detection in older adults. PMID: 23102807
    16. SNPs in autism spectrum disorders PMID: 23201551
    17. Copy number variations within GRM7 are not associated with schizophrenia in the Han Chinese population. PMID: 20078931
    18. This suggests that 3p25-26 is a new locus for severe recurrent depression. This represents the first report of a genome-wide significant locus for depression that also has an independent genome-wide significant replication. PMID: 21572164
    19. In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25). PMID: 21572167
    20. Data sets demonstrated a region of association for major depressive disorder within GRM7. Thus, the significance of this finding remains uncertain. PMID: 21813496
    21. we were unable to detect SUMOylation of full-length mGluR7 in either heterologous cells or neurons PMID: 21255632
    22. As a previous GWAS of a European and Finnish sample set already suggested a role for GRM7 in age-related hearing impairment, this study provides further evidence for the involvement of this gene. PMID: 20068591
    23. Identified additional splicing variants involving the 3' end of the GRM7 coding sequence and resulting in three putative novel isoforms. PMID: 12052533
    24. The results of this study support the possible association of a GRM7 gene polymorphism with genetic susceptibility to schizophrenia. PMID: 18329248
    25. GRM7 contributes to risk of developing age-related hearing impairment. PMID: 19047183
    26. Study results provide support for the idea that glutamatergic neurotransmission and specifically the GRM7 gene might be relevant to the development of schizophrenia. PMID: 19638256

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 組織特異性：
    Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.
  • 數據庫鏈接：

    HGNC: 4599

    OMIM: 604101

    KEGG: hsa:2917

    STRING: 9606.ENSP00000350348

    UniGene: Hs.606393



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