在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GRM7 Antibody

  • 中文名稱:
    GRM7兔多克隆抗體
  • 貨號:
    CSB-PA003237
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HuvEc cells using mGluR-7 Polyclonal Antibody
    • Western Blot analysis of RAT-KIDNEY cells using mGluR-7 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    FLJ40498 antibody; GLUR7 antibody; Glutamate receptor metabotropic 7 antibody; GPRC1G antibody; GRM7 antibody; GRM7_HUMAN antibody; Metabotropic glutamate receptor 7 antibody; MGLU7 antibody; mGluR7 antibody; OTTHUMP00000206961 antibody; OTTHUMP00000214674 antibody; OTTHUMP00000214675 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human mGluR-7.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits.
  • 基因功能參考文獻:
    1. The mutant allele C in rs1485175 of the GMR7 may decrease individuals' susceptibility to noise-induced hearing loss. PMID: 29301492
    2. The results of this study indicate that the GRM7 rs9814881 might be associated with MDD in the Chinese Han population. PMID: 28027116
    3. study to evaluate evidence for association between GRM7 and alcohol behaviors using an SNP approach, as well as a gene-based approach in two independent samples; Rs3749380 was suggestively associated with alcohol consumption in one sample with the minor T allele conferring risk; there was no evidence for association in the other sample PMID: 27788777
    4. Autism spectrum disorder (ASD) as a synaptopathy is revealed to be pertained to aberrant glutamatergic neurotransmission. Glutamate receptor, metabotropic 7 (GRM7) is a receptor coding gene of this pathway. PMID: 27312574
    5. GRM7 rs2133450 may have translational relevance as a predictor of response to risperidone in schizophrenia. PMID: 26856250
    6. Multiple genetic models identified 1 significant locus, GRM7, for 2 hypertension-derived traits. PMID: 26866891
    7. Study represents a genetic association test towards single variant and multi-markers interaction of GRM7 and GRM8 genes in both schizophrenia and major depressive disorders in Han Chinese population PMID: 26655190
    8. Glutamate system genes have been associated with disease risk in recent analyses from the Psychiatric Genomics Consortium. PMID: 26905411
    9. results indicate that the GRM7 SNPs rs13353402 and rs1531939 might be associated with schizophrenia in Chinese Han population. PMID: 26254163
    10. results reported here do not support a role for GRM7 in ADHD PMID: 25360607
    11. Copy number variants at GRM7 may have a role in the etiology of bipolar disorder. PMID: 24804643
    12. For neither PCLO nor GRM7 we found a more associated variant. For SLC6A4, we found a new SNP that showed a lower P-value than in the GAIN-MDD GWAS PMID: 24278217
    13. in an elderly male Han Chinese population, GRM7 SNP rs11928865 (TT) occurs more frequently in age-related hearing impairment patients with SL and AL phenotype patterns. PMID: 24146964
    14. These results provide preliminary evidence of an association between the GRM7 rs37952452 polymorphism and selective attention deficit and anxiety found within the Korean ADHD population PMID: 23295062
    15. Mixed modeling analyses explored the relationship of GRM7 haplotype and SNP genotypes with measures of auditory perception. GRM7 alleles are associated primarily with peripheral measures of hearing loss, and with speech detection in older adults. PMID: 23102807
    16. SNPs in autism spectrum disorders PMID: 23201551
    17. Copy number variations within GRM7 are not associated with schizophrenia in the Han Chinese population. PMID: 20078931
    18. This suggests that 3p25-26 is a new locus for severe recurrent depression. This represents the first report of a genome-wide significant locus for depression that also has an independent genome-wide significant replication. PMID: 21572164
    19. In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25). PMID: 21572167
    20. Data sets demonstrated a region of association for major depressive disorder within GRM7. Thus, the significance of this finding remains uncertain. PMID: 21813496
    21. we were unable to detect SUMOylation of full-length mGluR7 in either heterologous cells or neurons PMID: 21255632
    22. As a previous GWAS of a European and Finnish sample set already suggested a role for GRM7 in age-related hearing impairment, this study provides further evidence for the involvement of this gene. PMID: 20068591
    23. Identified additional splicing variants involving the 3' end of the GRM7 coding sequence and resulting in three putative novel isoforms. PMID: 12052533
    24. The results of this study support the possible association of a GRM7 gene polymorphism with genetic susceptibility to schizophrenia. PMID: 18329248
    25. GRM7 contributes to risk of developing age-related hearing impairment. PMID: 19047183
    26. Study results provide support for the idea that glutamatergic neurotransmission and specifically the GRM7 gene might be relevant to the development of schizophrenia. PMID: 19638256

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 3 family
  • 組織特異性:
    Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.
  • 數據庫鏈接:

    HGNC: 4599

    OMIM: 604101

    KEGG: hsa:2917

    STRING: 9606.ENSP00000350348

    UniGene: Hs.606393



主站蜘蛛池模板: 亚洲精品国产福利一区二区| 开心久久婷婷综合中文字幕| 国内精品伊人久久久久777| 欧美zozo另类特级| 国产超碰人人做人人爽av| 中国少妇xxxx做受| 国产一区二区内射最近更新| 久久精品无码一区二区无码| 18禁美女黄网站色大片免费网站| 国产精品调教视频一区| www一区二区www免费| 精品无码一区二区三区电影| 樱花草在线社区www日本影院| 精品国产天堂综合一区在线| 精品深夜av无码一区二区| 海角社区在线视频播放观看 | 亚洲亚洲人成无码网www| 日韩精品 中文字幕 视频在线| 欧美老熟妇牲交| 伊人亚洲综合影院首页| 亚洲人成电影免费观看在线看| 少妇激情一区二区三区视频 | 亚洲人成网站在线观看69影院| 久久综合激激的五月天| 免费人成网站视频在线观看国内 | 欧美日韩国产专区一区二区| 性按摩玩人妻hd中文字幕| 精品无码国产自产拍在线观看蜜 | 久久综合久色欧美综合狠狠| 国产私拍大尺度在线视频| 4480yy私人精品国产| 久久无码人妻一区二区三区午夜| 少妇高潮惨叫久久久久久| 国产99久9在线视频 | 传媒| 免费网站内射红桃视频| 久久久久成人网站| 国产精品99久久精品| 国产亚洲精品自在久久蜜tv| 色窝窝无码一区二区三区色欲| а√8天堂中文官网资源| 欧美成人精品 一区二区三区|