在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Melanotransferrin (MFI2)

  • 中文名稱:
    人MELTF重組蛋白
  • 貨號(hào):
    CSB-YP013754HU
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    人MELTF重組蛋白
  • 貨號(hào):
    CSB-EP013754HU-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人MELTF重組蛋白
  • 貨號(hào):
    CSB-BP013754HU
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人MELTF重組蛋白
  • 貨號(hào):
    CSB-MP013754HU
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Antigen p97; CD228; CD228 antigen; MAP97 ; Melanoma associated antigen p97; Melanoma-associated antigen p97; Melanotransferrin; Mfi2; MTF1 ; TRFM_HUMAN
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Full Length of Mature Protein
  • 表達(dá)區(qū)域:
    20-302
  • 氨基酸序列
    GMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSADHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVTIDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETSYSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDESPSRRQTWTRSEEEEGECPAHEEARRTMRSSAGQAWKWAPVHRPQDESDKGEFGKRAKSRDMLG
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.
  • 基因功能參考文獻(xiàn):
    1. Melanotransferrin is a serological marker of colorectal cancer by secretome analysis and quantitative proteomics. PMID: 25216327
    2. PC3 tumors are sustained by a small number of tumor-initiating cells with stem-like characteristics, including strong self-renewal and pro-angiogenic capability and marked by the expression pattern FAM65Bhigh/MFI2low/LEF1low. PMID: 21190562
    3. The human genome contains a second melanotransferrin gene (MTf2). There are two isoforms of melanotransferrin. PMID: 11852110
    4. its ability to donate 59Fe to SK-Mel-28 melanoma cells and other cell types PMID: 12230555
    5. membrane-bound and soluble p97 affect the migration capacity of endothelial and melanoma cells and suggest that p97 could be involved in the regulation of plasminogen activation by interacting with pro-uPA and plasminogen. PMID: 12750156
    6. Serum melanotransferrin exists in various conformations depending on the binding of bivalent cations or following post-translational modification; serum melanotransferrin levels are unchanged in subjects with Alzheimer's disease. PMID: 12809550
    7. The distribution of MTf and its splice variants may provide clues to their possible biological roles in melanoma and other tumors. PMID: 15716025
    8. melanotransferrin has a role in cell proliferation and tumorigenesis PMID: 16704991
    9. Anti-angiogenic properties of soluble melanotransferrin may result from local overstimulation of plasminogen activation by tissue plasminogen activator, thus leading to subsequent degradation of the fibronectin matrix and endothelial cell detachment. PMID: 16713448
    10. Altogether, these findings strongly suggest that MTf overexpression in melanoma cells contributes to tumor progression by stimulating plasmin generation as well as cell migration and invasion. PMID: 17196552
    11. HMB-45 (melanoma-associated antigen p97) and Melan-A combined were positive in 100% of the renal angiomyolipomas PMID: 17227112
    12. Novel molecular targets directly or indirectly regulated by MTf and the potential pathways involved in its function, including modulation of proliferation. PMID: 17449903
    13. this review discusses the studies that have demonstrated that melanotransferrin is not involved in iron metabolism, but plays a vital role in melanoma cell proliferation and tumorigenesis. PMID: 17452986
    14. Biochemical and spectroscopic studies of MTF1 are reported. PMID: 18691669

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族:
    Transferrin family
  • 組織特異性:
    Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 7037

    OMIM: 155750

    KEGG: hsa:4241

    STRING: 9606.ENSP00000296350

    UniGene: Hs.184727



主站蜘蛛池模板: 国产精品久久综合免费| 小sao货水好多真紧h视频| 无码人妻一区二区三区免费| 狠狠色综合久久丁香婷婷| 精品无人乱码高清在线观看| 亚洲熟妇自偷自拍另类| 摸丰满大乳奶水www免费| 欧美叉叉叉bbb网站| 欧美成人精精品一区二区| 伊人久久大香线蕉综合狠狠| 亚洲 丝袜 另类 校园 欧美| 男女啪啪永久免费观看网站| 日本强伦姧人妻一区二区| 秋霞最新高清无码鲁丝片| 粗大猛烈进出高潮视频| ass日本丰满熟妇pics| av大片在线无码永久免费| 午夜无码一区二区三区在线| 国产国拍精品av在线观看按摩| 午夜久久久久久禁播电影| 在线涩涩免费观看国产精品| 丁香婷婷六月综合交清| 美女内射毛片在线看3d| 久久无码人妻丰满熟妇区毛片| 久久香综合精品久久伊人| 国产成人午夜在线视频a站| 无码人妻精品中文字幕免费东京热| 校园春色~综合网| 久久男人av资源网站| 亚洲学生妹高清av| 五月开心播播网| 午夜美女裸体福利视频| 欧美精品一产区二产区| 色橹橹欧美在线观看视频高清| 国产精成人品| 色欲天天天无码视频| 无码人妻丝袜在线视频| 久热在线中文字幕色999舞| 麻豆丰满少妇chinese| 国产裸体xxxx视频| 无码成人一区二区三区|