在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Melanoma-associated antigen C2 (MAGEC2)

Recombinant Human Melanoma-associated antigen C2 (MAGEC2)

  • 中文名稱：
    人MAGEC2重組蛋白
  • 貨號：
    CSB-YP887003HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MAGEC2重組蛋白
  • 貨號：
    CSB-EP887003HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MAGEC2重組蛋白
  • 貨號：
    CSB-EP887003HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MAGEC2重組蛋白
  • 貨號：
    CSB-BP887003HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MAGEC2重組蛋白
  • 貨號：
    CSB-MP887003HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cancer testis antigen 10; Cancer/testis antigen 10; CT10; HCA587; Hepatocellular cancer antigen 587; Hepatocellular carcinoma associated antigen 587; Hepatocellular carcinoma-associated antigen 587; MAGC2_HUMAN; MAGE C2 antigen; MAGE E1 antigen; MAGE family member C2; MAGE-C2 antigen; MAGE-E1 antigen; MAGEC2; Melanoma antigen family C 2; Melanoma antigen family C2; Melanoma antigen family E 1 cancer/testis specific; Melanoma associated antigen C2; Melanoma-associated antigen C2; MGC13377
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-373
  • 氨基酸序列
    MPPVPGVPFR NVDNDSPTSV ELEDWVDAQH PTDEEEEEAS SASSTLYLVF SPSSFSTSSS LILGGPEEEE VPSGVIPNLT ESIPSSPPQG PPQGPSQSPL SSCCSSFSWS SFSEESSSQK GEDTGTCQGL PDSESSFTYT LDEKVAELVE FLLLKYEAEE PVTEAEMLMI VIKYKDYFPV ILKRAREFME LLFGLALIEV GPDHFCVFAN TVGLTDEGSD DEGMPENSLL IIILSVIFIK GNCASEEVIW EVLNAVGVYA GREHFVYGEP RELLTKVWVQ GHYLEYREVP HSSPPYYEFL WGPRAHSESI KKKVLEFLAK LNNTVPSSFP SWYKDALKDV EERVQATIDT ADDATVMASE SLSVMSSNVS FSE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

問答及客戶評論

■ 常見問題解答
Q:

We are interested in the following proteins expressed in mammalian with a concentration of 50ug/ml. Please let me know if this is possible for the following products:
We would also like to know if it’s possible to buy some of the antigen resuspension buffer you use?
We will be using these proteins to build a protein array for serum profiling and are unsure if they need aseptic processing or endotoxin removal?
Can you please advise whether this is necessary? We would like these proteins in eukaryotic host instead with a concentration of 50ug/ml.
CSB-MP009188HU
CSB-MP768782HU
CSB-MP013325HU
CSB-MP887003HU
CSB-MP013348HU
CSB-MP636766XBF
CSB-MP897569HU
CSB-MP009178HU
CSB-MP664879BO

A:
1.Thanks for your inquiry.
Recombinant Human Melanoma-associated antigen C2(MAGEC2)
CSB-YP887003HU >> Yeast
CSB-EP887003HU >> E.coli
CSB-BP887003HU >> Baculovirus
CSB-MP887003HU >> Mammalian cell
Expression Region: 1-373aa; Full length.
Tag information:EP, YP, BP, MP: Tag type will be determined during the manufacturing process.
The expected tag for each expression system is listed as follows:
YP: N-terminal 6xHis-tagged; EP, BP, MP: N-terminal 10xHis-tagged and C-terminal Myc-tagged.
Sequence:

MPPVPGVPFRNVDNDSPTSVELEDWVDAQHPTDEEEEEASSASSTLYLVFSPSSFSTSSSLILGGPEEEEVPSGVIPNLTESIPSSPPQGPPQGPSQSPLSSCCSSFSWSSFSEESSSQKGEDTGTCQGLPDSESSFTYTLDEKVAELVEFLLLKYEAEEPVTEAEMLMIVIKYKDYFPVILKRAREFMELLFGLALIEVGPDHFCVFANTVGLTDEGSDDEGMPENSLLIIILSVIFIKGNCASEEVIWEVLNAVGVYAGREHFVYGEPRELLTKVWVQGHYLEYREVPHSSPPYYEFLWGPRAHSESIKKKVLEFLAKLNNTVPSSFPSWYKDALKDVEERVQATIDTADDATVMASESLSVMSSNVSFSE


2. As you want these proteins expressed in mammalian with a concentration of 50ug/ml, generally the concentration for MP protein is 0.1-0.5mg/ml (100ug/ml-500ug/ml),
The concentration of 50ug/ml is a little low, the low concentration is not very good for the protein stability, so we recommend the concentration is better higher than 0.1mg/ml.
3. You would also like to know if it’s possible to buy some of the antigen resuspension buffer you use?
How much do you need for the buffer ? If it's not too much, we can provide some for free, such as 5ml or 10ml.
4.You will be using these proteins to build a protein array for serum profiling and are unsure if they need aseptic processing or endotoxin removal?
Can you please advise whether this is necessary? You would like these proteins in eukaryotic host instead with a concentration of 50ug/ml.
According to your application, they don't need aseptic processing or endotoxin removal.
Do you mean that the concentration of 50ug/ml is not necessary, as long as these proteins are expressed in eukaryotic host ?
If yes, we recommend the concentration is better higher than 100ug/ml, and you can choose any eukaryotic expression systems. (YP, BP, MP)

靶點詳情

  • 功能：
    Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.
  • 基因功能參考文獻：
    1. HCA587/MAGEC2 directly binds TAF9 via its CR domain, suggesting that HCA587/MAGEC2 may involve in TAF9 binding with DNA to regulate certain genes transcription. PMID: 29257297
    2. our findings revealed a previously unrecognized regulation of STAT3 activation in tumor cells by cancer/testis antigen MAGEC2, and provided a molecular mechanism for the oncogenic activity of MAGEC2 in cancer cells. PMID: 27775077
    3. High MAGE-C2 expression was found in 38.18% of triple negative breast cancer tissues and in 9.09% of adjacent tissues. High MAGE-C2 expression in TNBC patients was closely associated with tumor node metastasis and shorter survival time. PMID: 27843173
    4. our study provides a suitable cell model for exploring the biological functions of MAGEC2 in malignant cells, and sheds light on the molecular pathway by which MAGEC2 promotes tumor development. PMID: 27636589
    5. The expressions of MAGE-C2 mRNA and MAGE-C2 protein were closely associated with stage, metastasis of lung cancer. PMID: 26903162
    6. In gastrointestinal stromal tumors, 5/51 (10%) patients expressed MAGE-C2. High-grade GIST are more likely to express MAGE-C2. MAGE-C2 also significantly correlates with mitotic rate and tumor size. PMID: 24713551
    7. Our results indicate that MAGEC2 has a role in breast cancer metastasis through inducing epithelial-mesenchymal transition PMID: 24687377
    8. overexpression of HCA587 resulted in a significant enhancement of LMP1-induced IL-6 production. These data indicate that HCA587 is a new negative regulator of BS69 PMID: 24866244
    9. MAGE-C2 promotes growth and tumorigenicity of melanoma cells, phosphorylation of KAP1, and DNA damage repair. PMID: 23096706
    10. Cytotoxic T cell clones directed against MAGE-C2 peptides recognize EB81-melanoma tumor cells treated with interferon (IotaFN)-gamma. PMID: 22925930
    11. MAGE-C2/CT10 expression in prostate cancer correlates with the degree of malignancy and indicates a higher risk for biochemical recurrence after radical prostatectomy. PMID: 21754986
    12. MAGEC2 is a sensitive and novel marker for seminoma. PMID: 21780320
    13. p43-57 is the first HCA587-derived major histocompatibility complex class II-restricted epitope to fulfil all prerequisites for use as a peptide vaccine in patients with HCA587-expressing tumors PMID: 21595801
    14. HCA 587 may be a valuable target antigen for diagnosis and vaccination of hepatocelular carcinoma patients. PMID: 12920247
    15. identified 2 antigens encoded by gene MAGE-C2 which are recognized by several melanoma-specific cytolytic T lymphocyte clones isolated from a melanoma patient; both antigens are presented by HLA-A2 PMID: 14999777
    16. CT10 expression was more frequently found in squamous cell carcinoma than in adenocarcinoma. PMID: 15061963
    17. because of the expression pattern of gene MAGE-C2, this new antigen is strictly tumor-specific PMID: 17096150
    18. the MAGE-A3 and MAGE-C2 gene promoter regions are de-methylated in the presence of activated KIT but become methylated on inhibition of KIT, consistent with the downregulation of mRNA and protein PMID: 17495964
    19. MAGE-C2/CT-10 is expressed in hepatocellular carcinoma PMID: 18942708

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma.
  • 組織特異性：
    Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung c
  • 數據庫鏈接：

    HGNC: 13574

    OMIM: 300468

    KEGG: hsa:51438

    STRING: 9606.ENSP00000354660

    UniGene: Hs.123536



主站蜘蛛池模板： 精品日韩亚洲欧美高清a| 日本一卡二卡3卡四卡网站精品| 国产精品成人免费999| 国产日产欧产精品精品ai| 亚洲色偷偷偷网站色偷一区| 国产午夜福利不卡在线秋霞秋霞| 高清国产在线拍揄自揄视频| 国产精品亚洲专区无码破解版 | 特黄做受又粗又长又大又硬| 久久久久久国产精品mv| 欧美精品v欧洲精品| 人妻少妇av中文字幕乱码| 全部孕妇毛片丰满孕妇孕交| 精品无码一区二区三区不卡| 亚洲精品久久一区二区三区四区| 国产专区一线二线三线码| 午夜爽爽爽男女免费观看影院| 日韩免费码中文在线观看| av在线播放日韩亚洲欧我不卡| 一本加勒比hezyo中文无码| 男女18禁啪啪无遮挡| 欧美乱妇高清无乱码在线观看 | 无码人妻丰满熟妇精品区| 色欲av永久无码精品无码| 无码免费中文字幕视频| 67194熟妇在线观看线路| 999国产精品999久久久久久| 久久综合九色综合97网| 日韩av无码一区二区三区无码| 国产精品亚洲二区在线看| 乌克兰少妇xxxx做受| 国产国语老龄妇女a片| 亚洲中文无码a∨在线观看| 欧美婷婷丁香五月社区| 无码加勒比一区二区三区四区| 99精品众筹模特自拍视频| 无码免费毛片手机在线无卡顿| 色情无码一区二区三区| 99久久精品午夜一区二区| 亚洲第一狼人伊人av| 日本乱偷人妻中文字幕在线 |