在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human MAD2L1-binding protein (MAD2L1BP)

Recombinant Human MAD2L1-binding protein (MAD2L1BP)

  • 中文名稱：
    人MAD2L1BP重組蛋白
  • 貨號：
    CSB-YP624009HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MAD2L1BP重組蛋白
  • 貨號：
    CSB-EP624009HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MAD2L1BP重組蛋白
  • 貨號：
    CSB-EP624009HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MAD2L1BP重組蛋白
  • 貨號：
    CSB-BP624009HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MAD2L1BP重組蛋白
  • 貨號：
    CSB-MP624009HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MAD2L1BP
  • Uniprot No.：
  • 別名：
    Caught by MAD2 protein; CMT2; dJ261G23.1 ; KIAA0110; MAD2L1 binding protein; MAD2L1 binding protein isoform 2; MAD2L1-binding protein; Mad2l1bp; MD2BP_HUMAN; MGC11282; OTTHUMP00000016496; RP1 261G23.6
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-274
  • 氨基酸序列
    MAAPEAEVLS SAAVPDLEWY EKSEETHASQ IELLETSSTQ EPLNASEAFC PRDCMVPVVF PGPVSQEGCC QFTCELLKHI MYQRQQLPLP YEQLKHFYRK PSPQAEEMLK KKPRATTEVS SRKCQQALAE LESVLSHLED FFARTLVPRV LILLGGNALS PKEFYELDLS LLAPYSVDQS LSTAACLRRL FRAIFMADAF SELQAPPLMG TVVMAQGHRN CGEDWFRPKL NYRVPSRGHK LTVTLSCGRP SIRTTAWEDY IWFQAPVTFK GFRE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.
  • 基因功能參考文獻：
    1. MAD2-p31(comet) axis may serve as a potential therapeutic target for glioma. PMID: 29408509
    2. p31comet-induced cell death is mediated by interactions with Mad2 PMID: 26544187
    3. joint action of TRIP13 and p31(comet) also promotes the release of Mad2 from MCC, participates in the complete disassembly of MCC and abrogates checkpoint inhibition of APC/C PMID: 25092294
    4. Altered p31(Comet):Mad2 expression ratios may provide new insight into altered spindle assembly checkpoint function and the generation of chromosomal instability in tumors. PMID: 24131926
    5. attenuating the affinity of p31(Comet) for Mad2 by phosphorylation promotes SAC activity in mitosis. Specifically, phosphorylation of Ser-102 weakens p31(Comet)-Mad2 binding and enhances p31(Comet)-mediated bypass of the SAC. PMID: 24596092
    6. study found p31(comet) traffics on and off kinetochores and also present in the cytosol; Cells depleted of p31(comet) arrest in metaphase with mature bipolar kinetochore-microtubule attachments; propose that p31(comet) is an essential component of machinery that silences the checkpoint during each cell cycle PMID: 21965286
    7. the importance of p31(comet) in checkpoint silencing and its potential as a target for antimitotic therapies. PMID: 22544748
    8. The binding of p31(comet) to Mad2 in mitotic checkpoint complex may trigger a conformational change in Cdc20 that facilitates its phosphorylation by Cdk, and that the latter process may promote its dissociation from BubR1. PMID: 22566641
    9. both p31(comet) and ubiquitination of Cdc20 are critical mechanisms of checkpoint inactivation. They act redundantly to promote Mad2 dissociation from Cdc20 PMID: 21937719
    10. p31(comet) negatively regulates the spindle assembly checkpoint by extracting Mad2 from the MCC. PMID: 22100920
    11. This review presents knowledge of CMT2 and possible pathogenetic mechanisms responsible for the disease PMID: 22235654
    12. p31comet localizes to kinetochores in a C-Mad2-dependent manner. the Mad1:C-Mad2 complex undergoes regulation by p31comet-dependent 'capping'. PMID: 21772247
    13. Although p31(comet) binds to Mad2, it promotes the dissociation of Cdc20 from BubR1 in MCC. PMID: 21300909
    14. p31(comet, formerly known as Cmt2) counteracts the function of Mad2 and is required for the silencing of the spindle checkpoint PMID: 15257285
    15. p31(comet) does not have an impact on the formation of aneuploidy and tetraploidy found in human hepatocellular carcinoma. PMID: 17934339
    16. Data suggest that p31(comet)(CMT2) exploits the two-state behavior of Mad2 to block its activation by acting as an "anti-Mad2." PMID: 18022368
    17. p31(comet) induces tumor cell senescence by mediating p21(Waf1/Cip1) accumulation and Mad2 disruption and that these effects are dependent on a direct interaction of p31(comet) with Mad2. PMID: 19276188

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.
  • 蛋白家族：
    MAD2L1BP family
  • 數據庫鏈接：

    HGNC: 21059

    KEGG: hsa:9587

    STRING: 9606.ENSP00000410818

    UniGene: Hs.122346



主站蜘蛛池模板： 国产香蕉视频在线播放| 18禁黄网站禁片免费观看女女| 永久免费精品成人网站| 亚洲日韩亚洲另类| 国产色视频一区二区三区qq号| 成年轻人电影www无码| 亚洲精品久久久久高潮| 丰满无码人妻热妇无码区| 国产一区二区三区免费观看在线| 中文字幕在线观看亚洲视频| 国产日产欧产精品精品| 中文人妻熟妇乱又伦精品| 国产午夜av秒播在线观看| 亚洲愉拍自拍欧美精品| 欧美高清freexxxx性| 国产精品无码一区二区在线a片| 亚洲精品国产av现线| 国产又粗又大又黄| 香蕉午夜福利院| 日韩人妻无码精品系列| 国产无遮挡又黄又爽网站| 乱妇乱女熟妇熟女网站| 成av人电影在线观看| 亚洲日韩欧美国产另类综合| 国产成人精品一区二区秒播| 久久久亚洲一区二区三区| 亚洲欧美日韩国产成人精品影院| 国产精品videossex久久发布| 国产无套水多在线观看| 柠檬福利第一导航在线| 日本免费一区二区三区四区五六区| 亚洲中文字幕在线第二页 | 国产精品久久国产精麻豆99网站| 国产熟人av一二三区| 久久人人爽人人爽人人爽| 日本天天黄网站| 久久精品成人亚洲另类欧美| 亚洲熟女乱色综合亚洲图片| 十八禁真人啪啪免费网站| 亚洲中文字幕a∨在线| 日本护士毛茸茸|