在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Lysine-specific histone demethylase 1B (KDM1B), partial

  • 中文名稱:
    人KDM1B重組蛋白
  • 貨號:
    CSB-YP822748HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人KDM1B重組蛋白
  • 貨號:
    CSB-EP822748HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人KDM1B重組蛋白
  • 貨號:
    CSB-EP822748HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人KDM1B重組蛋白
  • 貨號:
    CSB-BP822748HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人KDM1B重組蛋白
  • 貨號:
    CSB-MP822748HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    KDM1B
  • Uniprot No.:
  • 別名:
    amine oxidase (flavin containing) domain 1 ; amine oxidase, flavin containing 1; AOF1; bA204B7.3; C6orf193; dJ298J15.2; Flavin-containing amine oxidase domain-containing protein 1; FLJ33898; FLJ34109; FLJ43328; KDM1B; KDM1B_HUMAN; LSD2; lysine (K)-specific demethylase 1B ; Lysine-specific demethylase 2; Lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.
  • 基因功能參考文獻:
    1. These results suggest that LSD2 achieves a promoting effect on small cell lung cancer by indirectly regulating TFPI2 expression through the mediation of DNMT3B expression or through the regulation of the demethylation of H3K4me1 in the promoter region of the TFPI2 gene. PMID: 29845195
    2. This review focuses on published small-molecule inhibitors targeted at the two flavin adenine dinucleotide-dependent lysine demethylases, lysine-specific demethylases 1 and 2, and how the inhibitors interact with the tertiary structures of the enzymes. PMID: 28277979
    3. These results demonstrate an important role for LSD2 in regulation of DNA methylation and gene silencing in breast cancer. PMID: 24924415
    4. Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT. PMID: 25773598
    5. Using transcriptome and chromatin immunoprecipitation-sequencing analyses, the study revealed that LSD2 represses the genes involved in lipid influx and metabolism through demethylation of histone H3K4. PMID: 25624347
    6. regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 PMID: 25036127
    7. The zinc finger-SWIRM-oxidase domains is required for KDM1B demethylase activity and the binding of FAD. PMID: 23266887
    8. Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. PMID: 20670891

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Flavin monoamine oxidase family
  • 數據庫鏈接:

    HGNC: 21577

    OMIM: 613081

    KEGG: hsa:221656

    STRING: 9606.ENSP00000297792

    UniGene: Hs.709336



主站蜘蛛池模板: 日韩av毛片无码免费| 国产卡一卡二无线乱码| 丝袜高潮流白浆潮喷在线播放 | 中文字幕日本六区小电影| 老司机午夜福利视频| 久章草国语自产拍在线观看| 伊人无码精品久久一区二区| 18禁止观看强奷免费国产大片 | 国产色在线 | 亚洲| 久久婷婷久久一区二区三区 | 男女裸交免费无遮挡全过程| 久久精品农村毛片| 亚洲日韩va在线视频| 亚洲精品av无码喷奶水网站| 东京热无码av男人的天堂| 精品夜夜爽欧美毛片视频 | 人妻系列影片无码专区| 国产亚洲精品字幕在线观看| 无码成人aaaaa毛片| 高清情侣国语自产拍| 欧美精品黑人粗大| 亚洲精品一卡2卡三卡4卡| 性xxxx视频播放免费| 国产麻豆9l精品三级站| 亚洲精品欧美精品日韩精品| 精品人妻系列无码专区| 中国免费看的片| 国产伦精品一区二区三区免费 | 97se亚洲国产综合自在线尤物| 久久精品成人免费观看97| 久久国产福利国产秒拍飘飘网| 狠狠躁夜夜躁人人爽天天天天| 人人超碰人摸人爱| 久久久久久人妻毛片a片| 无码专区—va亚洲v专区| 丰满人妻熟妇乱偷人无码| 黑人狠狠的挺身进入| 精品999日本久久久影院| 精品人妻系列无码一区二区三区| 在线精品一区二区三区| 久久久久青草线蕉亚洲麻豆|