在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KDM1B Antibody

KDM1B Antibody

  • 中文名稱：
    KDM1B兔多克隆抗體
  • 貨號：
    CSB-PA822748LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA822748LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA822748LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KDM1B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KDM1B
  • 別名：
    amine oxidase (flavin containing) domain 1 antibody; amine oxidase, flavin containing 1 antibody; AOF1 antibody; bA204B7.3 antibody; C6orf193 antibody; dJ298J15.2 antibody; Flavin-containing amine oxidase domain-containing protein 1 antibody; FLJ33898 antibody; FLJ34109 antibody; FLJ43328 antibody; KDM1B antibody; KDM1B_HUMAN antibody; LSD2 antibody; lysine (K)-specific demethylase 1B antibody; Lysine-specific demethylase 2 antibody; Lysine-specific histone demethylase 1B antibody; Lysine-specific histone demethylase 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Lysine-specific histone demethylase 1B protein (451-544AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，KDM1B Antibody (CSB-PA822748LA01HU)，的標記方式是Non-conjugated。對于KDM1B Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA822748LB01HU KDM1B Antibody, HRP conjugated ELISA
    FITC CSB-PA822748LC01HU KDM1B Antibody, FITC conjugated
    Biotin CSB-PA822748LD01HU KDM1B Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.
  • 基因功能參考文獻：
    1. These results suggest that LSD2 achieves a promoting effect on small cell lung cancer by indirectly regulating TFPI2 expression through the mediation of DNMT3B expression or through the regulation of the demethylation of H3K4me1 in the promoter region of the TFPI2 gene. PMID: 29845195
    2. This review focuses on published small-molecule inhibitors targeted at the two flavin adenine dinucleotide-dependent lysine demethylases, lysine-specific demethylases 1 and 2, and how the inhibitors interact with the tertiary structures of the enzymes. PMID: 28277979
    3. These results demonstrate an important role for LSD2 in regulation of DNA methylation and gene silencing in breast cancer. PMID: 24924415
    4. Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT. PMID: 25773598
    5. Using transcriptome and chromatin immunoprecipitation-sequencing analyses, the study revealed that LSD2 represses the genes involved in lipid influx and metabolism through demethylation of histone H3K4. PMID: 25624347
    6. regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 PMID: 25036127
    7. The zinc finger-SWIRM-oxidase domains is required for KDM1B demethylase activity and the binding of FAD. PMID: 23266887
    8. Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. PMID: 20670891

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Flavin monoamine oxidase family
  • 數據庫鏈接：

    HGNC: 21577

    OMIM: 613081

    KEGG: hsa:221656

    STRING: 9606.ENSP00000297792

    UniGene: Hs.709336



主站蜘蛛池模板： 成年无码av片在线免缓冲| 日韩亚洲欧美中文在线| 久久精品国产99精品国产2021| 人妻少妇被粗大爽9797pw| 久久精品成人免费观看三| 精品系列无码一区二区三区 | 欧美精品亚洲精品日韩专区| 亚洲精品中文字幕| 国产肥白大熟妇bbbb视频| 国内精品久久久久影院嫩草| 久久精品av麻豆| 国产亚洲精品自在久久vr| 风韵多水的老熟妇| 无码中文av有码中文av| 国产亚洲精品久久久久9999 | 国产精品久久久久无码av1| 免费三级网站| 精品久久久久久无码专区| 国产成人亚洲日韩欧美| 无码帝国www无码专区色综合| 国产二级一片内射视频插放| 日本熟妇大乳| 狠狠色狠狠色五月激情| 纯爱无遮挡h肉动漫在线播放| 日韩av激情在线观看| 掀开奶罩边吃边摸下娇喘视频| 久久综合久久自在自线精品自| 亚洲愉拍二区一区三区| 日本少妇高潮喷水xxxxxxx| 香港三级日本三级妇三级| 日本高清色www网站色噜噜噜| 国产av无码专区影视| 亚洲a∨国产av综合av下载| 麻批好紧日起要舒服死了| 国产婷婷亚洲999精品小说 | 野外被强j到高潮免费观看| 国产精品久久欧美久久一区| 亚洲午夜av久久久精品影院| 亚洲中文字幕无码久久2020| 波多野结衣超清无码专区| 亚洲欧美激情精品一区二区|