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  4. Recombinant Human Leucine-zipper-like transcriptional regulator 1 (LZTR1), partial

Recombinant Human Leucine-zipper-like transcriptional regulator 1 (LZTR1), partial

  • 中文名稱：
    人LZTR1重組蛋白
  • 貨號：
    CSB-YP836674HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人LZTR1重組蛋白
  • 貨號：
    CSB-EP836674HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人LZTR1重組蛋白
  • 貨號：
    CSB-EP836674HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LZTR1重組蛋白
  • 貨號：
    CSB-BP836674HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LZTR1重組蛋白
  • 貨號：
    CSB-MP836674HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    LZTR1
  • Uniprot No.：
  • 別名：
    Leucine zipper like regulator 1; Leucine zipper like transcription regulator 1; Leucine-zipper-like transcriptional regulator 1; LZTR-1; Lztr1; LZTR1_HUMAN; MGC21205; TCFL2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes.
  • 基因功能參考文獻：
    1. the malignancy risk in schwannomatosis is not well defined but may include an increased risk of malignant peripheral nerve sheath tumor in SMARCB1 Imaging protocols are also proposed for SMARCB1 and LZTR1 schwannomatosis and SMARCE1-related meningioma predisposition. PMID: 28620005
    2. Nerve lesions and LZTR1 germline mutations in segmental schwannomatosis. PMID: 27472264
    3. Data indicate that molecular analysis of leucine-zipper-like transcription regulator 1 (LZTR1) may contribute to the molecular characterization of schwannomatosis patients. PMID: 25335493
    4. We show for the first time that an inherited mutation in PBRM1 predisposes to RCC. PMID: 25795793
    5. Data confirm the relationship between mutations in LZTR1 and schwannomatosis. They indicate that germline mutations in LZTR1 confer an increased risk of vestibular schwannoma. PMID: 25480913
    6. Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas. PMID: 24362817
    7. LZTR-1 is the first BTB-kelch protein that exclusively localizes to the Golgi network PMID: 16356934

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  • 相關疾病：
    Schwannomatosis 2 (SWNTS2); Noonan syndrome 10 (NS10)
  • 亞細胞定位：
    Endomembrane system. Recycling endosome. Golgi apparatus.
  • 數據庫鏈接：

    HGNC: 6742

    OMIM: 600574

    KEGG: hsa:8216

    STRING: 9606.ENSP00000215739

    UniGene: Hs.78788



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