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  4. LZTR1 Antibody

LZTR1 Antibody

  • 中文名稱：
    LZTR1兔多克隆抗體
  • 貨號：
    CSB-PA836674ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA836674ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA836674ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) LZTR1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LZTR1
  • 別名：
    Leucine zipper like regulator 1 antibody; Leucine zipper like transcription regulator 1 antibody; Leucine-zipper-like transcriptional regulator 1 antibody; LZTR-1 antibody; Lztr1 antibody; LZTR1_HUMAN antibody; MGC21205 antibody; TCFL2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Leucine-zipper-like transcriptional regulator 1 protein (300-545AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes.
  • 基因功能參考文獻：
    1. the malignancy risk in schwannomatosis is not well defined but may include an increased risk of malignant peripheral nerve sheath tumor in SMARCB1 Imaging protocols are also proposed for SMARCB1 and LZTR1 schwannomatosis and SMARCE1-related meningioma predisposition. PMID: 28620005
    2. Nerve lesions and LZTR1 germline mutations in segmental schwannomatosis. PMID: 27472264
    3. Data indicate that molecular analysis of leucine-zipper-like transcription regulator 1 (LZTR1) may contribute to the molecular characterization of schwannomatosis patients. PMID: 25335493
    4. We show for the first time that an inherited mutation in PBRM1 predisposes to RCC. PMID: 25795793
    5. Data confirm the relationship between mutations in LZTR1 and schwannomatosis. They indicate that germline mutations in LZTR1 confer an increased risk of vestibular schwannoma. PMID: 25480913
    6. Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas. PMID: 24362817
    7. LZTR-1 is the first BTB-kelch protein that exclusively localizes to the Golgi network PMID: 16356934

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  • 相關疾病：
    Schwannomatosis 2 (SWNTS2); Noonan syndrome 10 (NS10)
  • 亞細胞定位：
    Endomembrane system. Recycling endosome. Golgi apparatus.
  • 數據庫鏈接：

    HGNC: 6742

    OMIM: 600574

    KEGG: hsa:8216

    STRING: 9606.ENSP00000215739

    UniGene: Hs.78788



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