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  4. Recombinant Human KN motif and ankyrin repeat domain-containing protein 1 (KANK1), partial

Recombinant Human KN motif and ankyrin repeat domain-containing protein 1 (KANK1), partial

  • 中文名稱：
    人KANK1重組蛋白
  • 貨號：
    CSB-YP614803HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KANK1重組蛋白
  • 貨號：
    CSB-EP614803HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KANK1重組蛋白
  • 貨號：
    CSB-EP614803HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KANK1重組蛋白
  • 貨號：
    CSB-BP614803HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KANK1重組蛋白
  • 貨號：
    CSB-MP614803HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    KANK1
  • Uniprot No.：
  • 別名：
    ANKRD 15; Ankyrin repeat domain 15; Ankyrin repeat domain containing protein 15; Ankyrin repeat domain-containing protein 15; DKFZp451G231; KANK; KANK1; KANK1_HUMAN; KIAA0172; Kidney ankyrin repeat containing protein; Kidney ankyrin repeat-containing protein; KN motif and ankyrin repeat domain-containing protein 1; MGC43128
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways.
  • 基因功能參考文獻：
    1. Several key residues (i.e. Thr-1147, Leu-1152, Leu-1153, and Tyr-1154) at the C-terminal half of the KIF21A KBD peptide contact with the hydrophobic patch formed by Tyr-1176, Met-1209, Leu-1210, Leu-1213, and Leu-1248 from KANK1. PMID: 29158259
    2. Low KANK1 expression is associated with lung cancer progression. PMID: 29956815
    3. KANK1 inhibits Malignant peripheral nerve sheath tumors cell growth though CXXC5 mediated apoptosis. PMID: 28067315
    4. Upregulating the Kank1 gene can inhibit the progress of gastric cancer. PMID: 28731169
    5. Here, the authors show that cortical microtubule stabilization sites containing CLASPs, KIF21A, LL5beta and liprins are recruited to focal adhesions by the adaptor protein KANK1, which directly interacts with the major adhesion component, talin. Structural studies showed that the conserved KN domain in KANK1 binds to the talin rod domain R7. PMID: 27410476
    6. liprin beta-1 is associated with expression of kank 1 and 2 proteins in melanoma PMID: 26739330
    7. primary results revealed new function of Kank1 for nasopharyngeal cancer PMID: 25973051
    8. identified recessive mutations in kidney ankyrin repeat-containing protein 1 (KANK1), KANK2, and KANK4 in individuals with nephrotic syndrome. PMID: 25961457
    9. Thus, the human brain glioma apoptosis induced by upregulation of the Kank1 gene is closely relevant to the mitochondrial pathway. PMID: 24399197
    10. Our case suggests that KANK1 may be subject to random monoallelic expression as a possible mode of inheritance. PMID: 23454270
    11. ANKRD15 encodes the kidney ankyrin repeat-containing protein. PMID: 22876580
    12. KANK1, a candidate tumor suppressor gene, is fused to PDGFRB in an imatinib-responsive myeloid neoplasm with severe thrombocythemia. PMID: 20164854
    13. Kank is localized to 9p24 and plays a role in cell growth PMID: 12133830
    14. Human Kank gene has several alternative first exons. PMID: 15823577
    15. Kank can bind to beta-catenin and regulate the subcellular distribution of beta-catenin. PMID: 16968744
    16. Data suggest that Kank negatively regulates the formation of actin stress fibers and cell migration through the inhibition of RhoA activity, which is controlled by binding of Kank to 14-3-3 in PI3K-Akt signaling. PMID: 18458160
    17. These results suggest that KIF21A regulates the distribution of Kank1 and that KIF21A mutations associated with congenital fibrosis of the extraocular muscles type 1 enhanced the accumulation of Kank1 in the membrane fraction. PMID: 19559006

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  • 相關(guān)疾病：
    Cerebral palsy, spastic quadriplegic 2 (CPSQ2)
  • 亞細胞定位：
    Cell projection, ruffle membrane. Cytoplasm. Nucleus.; [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.
  • 組織特異性：
    Widely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19309

    OMIM: 607704

    KEGG: hsa:23189

    STRING: 9606.ENSP00000371734

    UniGene: Hs.306764



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