在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KANK1 Antibody

  • 中文名稱:
    KANK1兔多克隆抗體
  • 貨號:
    CSB-PA011982GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    KANK1
  • 別名:
    ANKRD 15 antibody; Ankyrin repeat domain 15 antibody; Ankyrin repeat domain containing protein 15 antibody; Ankyrin repeat domain-containing protein 15 antibody; DKFZp451G231 antibody; KANK antibody; KANK1 antibody; KANK1_HUMAN antibody; KIAA0172 antibody; Kidney ankyrin repeat containing protein antibody; Kidney ankyrin repeat-containing protein antibody; KN motif and ankyrin repeat domain-containing protein 1 antibody; MGC43128 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human KANK1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways.
  • 基因功能參考文獻:
    1. Several key residues (i.e. Thr-1147, Leu-1152, Leu-1153, and Tyr-1154) at the C-terminal half of the KIF21A KBD peptide contact with the hydrophobic patch formed by Tyr-1176, Met-1209, Leu-1210, Leu-1213, and Leu-1248 from KANK1. PMID: 29158259
    2. Low KANK1 expression is associated with lung cancer progression. PMID: 29956815
    3. KANK1 inhibits Malignant peripheral nerve sheath tumors cell growth though CXXC5 mediated apoptosis. PMID: 28067315
    4. Upregulating the Kank1 gene can inhibit the progress of gastric cancer. PMID: 28731169
    5. Here, the authors show that cortical microtubule stabilization sites containing CLASPs, KIF21A, LL5beta and liprins are recruited to focal adhesions by the adaptor protein KANK1, which directly interacts with the major adhesion component, talin. Structural studies showed that the conserved KN domain in KANK1 binds to the talin rod domain R7. PMID: 27410476
    6. liprin beta-1 is associated with expression of kank 1 and 2 proteins in melanoma PMID: 26739330
    7. primary results revealed new function of Kank1 for nasopharyngeal cancer PMID: 25973051
    8. identified recessive mutations in kidney ankyrin repeat-containing protein 1 (KANK1), KANK2, and KANK4 in individuals with nephrotic syndrome. PMID: 25961457
    9. Thus, the human brain glioma apoptosis induced by upregulation of the Kank1 gene is closely relevant to the mitochondrial pathway. PMID: 24399197
    10. Our case suggests that KANK1 may be subject to random monoallelic expression as a possible mode of inheritance. PMID: 23454270
    11. ANKRD15 encodes the kidney ankyrin repeat-containing protein. PMID: 22876580
    12. KANK1, a candidate tumor suppressor gene, is fused to PDGFRB in an imatinib-responsive myeloid neoplasm with severe thrombocythemia. PMID: 20164854
    13. Kank is localized to 9p24 and plays a role in cell growth PMID: 12133830
    14. Human Kank gene has several alternative first exons. PMID: 15823577
    15. Kank can bind to beta-catenin and regulate the subcellular distribution of beta-catenin. PMID: 16968744
    16. Data suggest that Kank negatively regulates the formation of actin stress fibers and cell migration through the inhibition of RhoA activity, which is controlled by binding of Kank to 14-3-3 in PI3K-Akt signaling. PMID: 18458160
    17. These results suggest that KIF21A regulates the distribution of Kank1 and that KIF21A mutations associated with congenital fibrosis of the extraocular muscles type 1 enhanced the accumulation of Kank1 in the membrane fraction. PMID: 19559006

    顯示更多

    收起更多

  • 相關疾病:
    Cerebral palsy, spastic quadriplegic 2 (CPSQ2)
  • 亞細胞定位:
    Cell projection, ruffle membrane. Cytoplasm. Nucleus.; [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.
  • 組織特異性:
    Widely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels.
  • 數據庫鏈接:

    HGNC: 19309

    OMIM: 607704

    KEGG: hsa:23189

    STRING: 9606.ENSP00000371734

    UniGene: Hs.306764



主站蜘蛛池模板: 国产欧美日韩一区二区三区| 亚洲精品www久久久久久| 久久精品中文字幕一区二区三区 | 久久精品99无色码中文字幕| 亚洲中文字幕无码天然素人| 青青草在在观免费福利线观看| 无码人妻黑人中文字幕| 人人妻人人澡人人爽欧美二区| 一本本月无码-| 亚洲欧美日韩国产综合点击进入| 天堂网www天堂资源网| 日韩中文亚洲欧美视频二| 中国女人高潮hd| 天堂资源在线www中文| 国产精品自产拍在线18禁| 欧美国产日韩亚洲中文| 久久精品一区二区免费播放| 玩弄中年熟妇正在播放| 久青草无码视频在线观看| 久久视频这里只精品99| av在线播放日韩亚洲欧我不卡| 欧美肥妇bwbwbwbxx| 国产激情久久久久影院老熟女免费| 免费人成视频在线观看不卡| 国产亚洲精品久久久999蜜臀| 欧美三级a做爰在线观看| 全部免费毛片在线播放| 日本午夜免费啪视频在线| 免费无遮挡很爽很污很黄的网站 | 国产精品无码一区二区在线观一| 非洲人与性动交ccoo| 久久97国产超碰青草| 人妻无码少妇一区二区| 日韩少妇人妻vs中文字幕| 强开小婷嫩苞又嫩又紧视频| 亚洲人成人无码网www国产| 男女啪啪免费观看的网址| 国产成人久久综合第一区| 精品深夜av无码一区二区老年| 久精品国产欧美亚洲色aⅴ大片| 狠狠色噜噜狠狠狠888777米奇|