在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KANK1 Antibody, HRP conjugated

  • 中文名稱:
    KANK1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA614803LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KANK1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KANK1
  • 別名:
    ANKRD 15 antibody; Ankyrin repeat domain 15 antibody; Ankyrin repeat domain containing protein 15 antibody; Ankyrin repeat domain-containing protein 15 antibody; DKFZp451G231 antibody; KANK antibody; KANK1 antibody; KANK1_HUMAN antibody; KIAA0172 antibody; Kidney ankyrin repeat containing protein antibody; Kidney ankyrin repeat-containing protein antibody; KN motif and ankyrin repeat domain-containing protein 1 antibody; MGC43128 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human KN motif and ankyrin repeat domain-containing protein 1 protein (66-255AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways.
  • 基因功能參考文獻:
    1. Several key residues (i.e. Thr-1147, Leu-1152, Leu-1153, and Tyr-1154) at the C-terminal half of the KIF21A KBD peptide contact with the hydrophobic patch formed by Tyr-1176, Met-1209, Leu-1210, Leu-1213, and Leu-1248 from KANK1. PMID: 29158259
    2. Low KANK1 expression is associated with lung cancer progression. PMID: 29956815
    3. KANK1 inhibits Malignant peripheral nerve sheath tumors cell growth though CXXC5 mediated apoptosis. PMID: 28067315
    4. Upregulating the Kank1 gene can inhibit the progress of gastric cancer. PMID: 28731169
    5. Here, the authors show that cortical microtubule stabilization sites containing CLASPs, KIF21A, LL5beta and liprins are recruited to focal adhesions by the adaptor protein KANK1, which directly interacts with the major adhesion component, talin. Structural studies showed that the conserved KN domain in KANK1 binds to the talin rod domain R7. PMID: 27410476
    6. liprin beta-1 is associated with expression of kank 1 and 2 proteins in melanoma PMID: 26739330
    7. primary results revealed new function of Kank1 for nasopharyngeal cancer PMID: 25973051
    8. identified recessive mutations in kidney ankyrin repeat-containing protein 1 (KANK1), KANK2, and KANK4 in individuals with nephrotic syndrome. PMID: 25961457
    9. Thus, the human brain glioma apoptosis induced by upregulation of the Kank1 gene is closely relevant to the mitochondrial pathway. PMID: 24399197
    10. Our case suggests that KANK1 may be subject to random monoallelic expression as a possible mode of inheritance. PMID: 23454270
    11. ANKRD15 encodes the kidney ankyrin repeat-containing protein. PMID: 22876580
    12. KANK1, a candidate tumor suppressor gene, is fused to PDGFRB in an imatinib-responsive myeloid neoplasm with severe thrombocythemia. PMID: 20164854
    13. Kank is localized to 9p24 and plays a role in cell growth PMID: 12133830
    14. Human Kank gene has several alternative first exons. PMID: 15823577
    15. Kank can bind to beta-catenin and regulate the subcellular distribution of beta-catenin. PMID: 16968744
    16. Data suggest that Kank negatively regulates the formation of actin stress fibers and cell migration through the inhibition of RhoA activity, which is controlled by binding of Kank to 14-3-3 in PI3K-Akt signaling. PMID: 18458160
    17. These results suggest that KIF21A regulates the distribution of Kank1 and that KIF21A mutations associated with congenital fibrosis of the extraocular muscles type 1 enhanced the accumulation of Kank1 in the membrane fraction. PMID: 19559006

    顯示更多

    收起更多

  • 相關疾病:
    Cerebral palsy, spastic quadriplegic 2 (CPSQ2)
  • 亞細胞定位:
    Cell projection, ruffle membrane. Cytoplasm. Nucleus.; [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.
  • 組織特異性:
    Widely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels.
  • 數據庫鏈接:

    HGNC: 19309

    OMIM: 607704

    KEGG: hsa:23189

    STRING: 9606.ENSP00000371734

    UniGene: Hs.306764



主站蜘蛛池模板: 亚洲成aⅴ人最新无码| 亚洲国产av玩弄放荡人妇| 国产婷婷亚洲999精品小说| 少妇无码av无码去区钱| 无套中出丰满人妻无码| 国语国产精精品国产国语清晰对话| 国产中文欧美日韩在线| 日韩插啊免费视频在线观看| 国产av久久久久精东av| 亚洲精品嫩草研究院久久| 国内精品视频一区二区三区| 中文在线中文资源| 欧美品无码一区二区三区在线蜜桃| 无码人妻一区、二区、三区免费视频| 亚洲国产精品一区二区www| 荡女精品导航| 日韩精品人涩人| 日韩国产成人无码av毛片蜜柚| 人妻无码久久一区二区三区免费 | 99在线精品免费视频九九视| 亚洲成本人无码薄码区| 好硬好湿好爽再深一点动态图视频 | 国产精品无码专区在线观看 | 日本少妇寂寞少妇aaa| 亚洲自偷自拍熟女另类| 波多野42部无码喷潮| 亚洲国产欧美国产综合久久| 18禁黄久久久aaa片| 欧美老妇与zozoz0交| 国产精品国产成人国产三级| 在线视频免费无码专区| 欧美国产日本高清不卡| 夜夜夜夜曰天天天天拍国产| 亚洲人成无码区在线观看| 少妇无码av无码专区线y| 男女后进式猛烈xx00动态图片| 国产精品欧美一区二区三区| 国产精品三级av及在线观看| 欧美乱大交xxxxx疯狂俱乐部| 老鸭窝视频在线观看| 亚洲欧美成人综合图区|