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  2. 蛋白
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  4. Recombinant Human Involucrin (IVL)

Recombinant Human Involucrin (IVL)

  • 中文名稱：
    人IVL重組蛋白
  • 貨號：
    CSB-YP011922HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人IVL重組蛋白
  • 貨號：
    CSB-EP011922HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人IVL重組蛋白
  • 貨號：
    CSB-EP011922HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人IVL重組蛋白
  • 貨號：
    CSB-BP011922HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人IVL重組蛋白
  • 貨號：
    CSB-MP011922HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    INVO_HUMAN; Involucrin; IVL
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-585
  • 氨基酸序列
    MSQQHTLPVT LSPALSQELL KTVPPPVNTH QEQMKQPTPL PPPCQKVPVE LPVEVPSKQE EKHMTAVKGL PEQECEQQQK EPQEQELQQQ HWEQHEEYQK AENPEQQLKQ EKTQRDQQLN KQLEEEKKLL DQQLDQELVK RDEQLGMKKE QLLELPEQQE GHLKHLEQQE GQLKHPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPQQQE GQLELSEQQE GQLELSEQQE GQLKHLEHQE GQLEVPEEQM GQLKYLEQQE GQLKHLDQQE KQPELPEQQM GQLKHLEQQE GQPKHLEQQE GQLEQLEEQE GQLKHLEQQE GQLEHLEHQE GQLGLPEQQV LQLKQLEKQQ GQPKHLEEEE GQLKHLVQQE GQLKHLVQQE GQLEQQERQV EHLEQQVGQL KHLEEQEGQL KHLEQQQGQL EVPEQQVGQP KNLEQEEKQL ELPEQQEGQV KHLEKQEAQL ELPEQQVGQP KHLEQQEKHL EHPEQQDGQL KHLEQQEGQL KDLEQQKGQL EQPVFAPAPG QVQDIQPALP TKGEVLLPVE HQQQKQEVQW PPKHK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
  • 基因功能參考文獻：
    1. Together, these results suggest that GR modulates involucrin expression of keratinocytes by regulating the intracellular signaling network in a ligand-independent manner. PMID: 24515279
    2. over-expression of Nnat was evident along with involucrin and cytokeratin1 expression PMID: 24252747
    3. involucrin is up-regulated in psoriatic keratinocytes PMID: 23283814
    4. KLF4 is part of a multiprotein complex that interacts that the hINV promoter distal regulatory region to drive differentiation-dependent hINV gene expression in epidermis. PMID: 23599428
    5. Compared with the control, the level of expression of the IVL gene in NCTC 2544 cells was increased after 8 h of treatment with hyaluronic acid or Plantaricin A preparations. PMID: 22742591
    6. Therefore, together with trichohyalin, the cross-linking due to involucrin is also responsible for the mechanical resistance of the corneous trabeculae present among the empty spaces of the medulla of the human hair. PMID: 22197495
    7. The authors found that HPV 16 E6 but not E7 repressed IVL promoter activity in proliferating human foreskin keratinocyte cells. PMID: 22333115
    8. higher expression in the fetal skin than in adult skin PMID: 19701759
    9. expression of the epidermal differentiation complex genes filaggrin and involucrin was strongly decreased directly by IL-13. PMID: 20208004
    10. Transcriptional activation of the involucrin gene by calcium in keratinocytes. PMID: 9159190
    11. involucrin gene contains distinct regulatory elements that regulate expression during epidermal differentiation PMID: 11850802
    12. transactivation of involucrin by lens epithelium-derived growth factor (LEDGF) PMID: 12126624
    13. the AP-1 site and the vitamin D response element in the involucrin promoter play important roles in mediating the action of 1,25-dihydroxyvitamin D3 on involucrin expression PMID: 12445200
    14. p38 delta is the major p38 isoform driving suprabasal hINV gene expression PMID: 12810719
    15. role for AP1 transcription factors in the regulation of human corneal epithelial cell involucrin gene expression. PMID: 15037572
    16. human involucrin promoter activity is regulated by green tea polyphenol and curcumin via opposing effects on CCAAT/enhancer-binding protein function PMID: 15044435
    17. cascade regulates activator protein one, Sp1, and CCATT/enhancer-binding protein transcription factor DNA binding to two discrete involucrin promoter regions, the distal- and proximal-regulatory regions, to regulate involucrin gene expression. PMID: 15191537
    18. cholesterol depletion alters involucrin gene expression through activation of p38alpha/beta. PMID: 15304097
    19. YY-1 and c-Jun transcription factors participate in the repression of the human involucrin promoter. PMID: 15586248
    20. Involucrin expression of keratinocytes is suppressed by roxithromycin through direct inhibition of AP-1 and indirect inhibition of NF-kappaB. PMID: 16140218
    21. AP1, Sp1, and C/EBP transcription factors are required for appropriate differentiation-dependent involucrin expression. PMID: 16374477
    22. involucrin gene expression inhibition by apigenin is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311 PMID: 16982614
    23. Pyk2 regulation is associated with increased expression of Fra-1 and JunD, activator protein-1 transcription factors known to be required for involucrin expression. PMID: 17205062
    24. There is a major role for STAT5a in the differentiation of keratinocytes, where it contributes to involucrin expression by activating the PPARgamma signal. PMID: 17330131
    25. BAG-1L also potentiated transactivation of known vitamin-D-responsive gene promoters, osteocalcin and 24-hydroxylase, and enhanced VDR-dependent transcription and protein expression of the keratinocyte differentiation marker, involucrin. PMID: 17662274
    26. a large multiprotein complex, which includes Fra-1, p300, P/CAF, junD, junB, and Sp1 acts at the AP1-5 site to produce a synergistic increase in hINV gene expression PMID: 17882273
    27. These findings indicate that PKCdelta activity for activation of involucrin promoter requires Y(311) and a second tyrosine residue; however, any one of the several tyrosine residues can serve in the secondary role. PMID: 17943181
    28. PPAR gamma regulates involucrin expression by controlling the AP-1 signal and p38 activation in 1 alpha,25(OH)2D3-induced keratinocyte differentiation. PMID: 18077140
    29. The expression of loricrin and involucrin in invovled and uninvolved skin of patients with atopic dermatitis is reported. PMID: 18166499
    30. siRNA for PRKD1 resulted in reduction of mRNA levels of PKD1, altered cell phenotype and promotion of keratinocyte differentiation, demonstrated by increased expression of involucrin and keratin 10 mRNAs PMID: 18259765
    31. RT-PCR and western blot analysis revealed a delay in the expression of the differentiation markers K1, K10 and involucrin in HaCaT cells compared with normal human keratinocytes PMID: 18637039
    32. Infection by HPV may alter the differentiation status of the epidermis, leading to earlier involucrin expression PMID: 19515043

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  • 亞細胞定位：
    Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope.
  • 蛋白家族：
    Involucrin family
  • 組織特異性：
    Keratinocytes of epidermis and other stratified squamous epithelia.
  • 數據庫鏈接：

    HGNC: 6187

    OMIM: 147360

    KEGG: hsa:3713

    STRING: 9606.ENSP00000357753

    UniGene: Hs.516439



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