在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IVL Antibody, HRP conjugated

  • 中文名稱:
    IVL兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA011922LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) IVL Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    INVO_HUMAN antibody; Involucrin antibody; IVL antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Involucrin protein (24-118AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
  • 基因功能參考文獻:
    1. Together, these results suggest that GR modulates involucrin expression of keratinocytes by regulating the intracellular signaling network in a ligand-independent manner. PMID: 24515279
    2. over-expression of Nnat was evident along with involucrin and cytokeratin1 expression PMID: 24252747
    3. involucrin is up-regulated in psoriatic keratinocytes PMID: 23283814
    4. KLF4 is part of a multiprotein complex that interacts that the hINV promoter distal regulatory region to drive differentiation-dependent hINV gene expression in epidermis. PMID: 23599428
    5. Compared with the control, the level of expression of the IVL gene in NCTC 2544 cells was increased after 8 h of treatment with hyaluronic acid or Plantaricin A preparations. PMID: 22742591
    6. Therefore, together with trichohyalin, the cross-linking due to involucrin is also responsible for the mechanical resistance of the corneous trabeculae present among the empty spaces of the medulla of the human hair. PMID: 22197495
    7. The authors found that HPV 16 E6 but not E7 repressed IVL promoter activity in proliferating human foreskin keratinocyte cells. PMID: 22333115
    8. higher expression in the fetal skin than in adult skin PMID: 19701759
    9. expression of the epidermal differentiation complex genes filaggrin and involucrin was strongly decreased directly by IL-13. PMID: 20208004
    10. Transcriptional activation of the involucrin gene by calcium in keratinocytes. PMID: 9159190
    11. involucrin gene contains distinct regulatory elements that regulate expression during epidermal differentiation PMID: 11850802
    12. transactivation of involucrin by lens epithelium-derived growth factor (LEDGF) PMID: 12126624
    13. the AP-1 site and the vitamin D response element in the involucrin promoter play important roles in mediating the action of 1,25-dihydroxyvitamin D3 on involucrin expression PMID: 12445200
    14. p38 delta is the major p38 isoform driving suprabasal hINV gene expression PMID: 12810719
    15. role for AP1 transcription factors in the regulation of human corneal epithelial cell involucrin gene expression. PMID: 15037572
    16. human involucrin promoter activity is regulated by green tea polyphenol and curcumin via opposing effects on CCAAT/enhancer-binding protein function PMID: 15044435
    17. cascade regulates activator protein one, Sp1, and CCATT/enhancer-binding protein transcription factor DNA binding to two discrete involucrin promoter regions, the distal- and proximal-regulatory regions, to regulate involucrin gene expression. PMID: 15191537
    18. cholesterol depletion alters involucrin gene expression through activation of p38alpha/beta. PMID: 15304097
    19. YY-1 and c-Jun transcription factors participate in the repression of the human involucrin promoter. PMID: 15586248
    20. Involucrin expression of keratinocytes is suppressed by roxithromycin through direct inhibition of AP-1 and indirect inhibition of NF-kappaB. PMID: 16140218
    21. AP1, Sp1, and C/EBP transcription factors are required for appropriate differentiation-dependent involucrin expression. PMID: 16374477
    22. involucrin gene expression inhibition by apigenin is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311 PMID: 16982614
    23. Pyk2 regulation is associated with increased expression of Fra-1 and JunD, activator protein-1 transcription factors known to be required for involucrin expression. PMID: 17205062
    24. There is a major role for STAT5a in the differentiation of keratinocytes, where it contributes to involucrin expression by activating the PPARgamma signal. PMID: 17330131
    25. BAG-1L also potentiated transactivation of known vitamin-D-responsive gene promoters, osteocalcin and 24-hydroxylase, and enhanced VDR-dependent transcription and protein expression of the keratinocyte differentiation marker, involucrin. PMID: 17662274
    26. a large multiprotein complex, which includes Fra-1, p300, P/CAF, junD, junB, and Sp1 acts at the AP1-5 site to produce a synergistic increase in hINV gene expression PMID: 17882273
    27. These findings indicate that PKCdelta activity for activation of involucrin promoter requires Y(311) and a second tyrosine residue; however, any one of the several tyrosine residues can serve in the secondary role. PMID: 17943181
    28. PPAR gamma regulates involucrin expression by controlling the AP-1 signal and p38 activation in 1 alpha,25(OH)2D3-induced keratinocyte differentiation. PMID: 18077140
    29. The expression of loricrin and involucrin in invovled and uninvolved skin of patients with atopic dermatitis is reported. PMID: 18166499
    30. siRNA for PRKD1 resulted in reduction of mRNA levels of PKD1, altered cell phenotype and promotion of keratinocyte differentiation, demonstrated by increased expression of involucrin and keratin 10 mRNAs PMID: 18259765
    31. RT-PCR and western blot analysis revealed a delay in the expression of the differentiation markers K1, K10 and involucrin in HaCaT cells compared with normal human keratinocytes PMID: 18637039
    32. Infection by HPV may alter the differentiation status of the epidermis, leading to earlier involucrin expression PMID: 19515043

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope.
  • 蛋白家族:
    Involucrin family
  • 組織特異性:
    Keratinocytes of epidermis and other stratified squamous epithelia.
  • 數據庫鏈接:

    HGNC: 6187

    OMIM: 147360

    KEGG: hsa:3713

    STRING: 9606.ENSP00000357753

    UniGene: Hs.516439



主站蜘蛛池模板: 夜夜夜夜猛噜噜噜噜噜试看 | 十八禁啪啪无遮挡网站| 国产成人午夜无码电影在线观看| 开心五月激情综合婷婷色| 国产免费无遮挡吸乳视频| 国产精品乱码在线观看| 久久天天躁夜夜躁狠狠85台湾| 强制高潮18xxxxhd日韩| 国产成人一区二区三区| 亚洲午夜无码毛片av久久京东热| 18禁真人抽搐一进一出在线| 国产欧美另类久久久精品不卡| 无码国产69精品久久久孕妇| 久久久久88色偷偷| 国产精品国产三级国产av麻豆| 巨爆乳中文字幕巨爆区巨爆乳无码| 少妇人妻偷人精品无码视频| 人妻夜夜爽天天爽三区麻豆av网站 | 尤物av无码国产在线看| 亚洲乱码日产一区三区| 国语自产偷拍精品视频蜜芽| 在线观看肉片av网站免费| 97人妻人人做人碰人人爽| 国产午夜精品免费一区二区三区| 亚洲日韩成人无码不卡网站 | 97久久精品人人槡人妻人| 国内精品久久毛片一区二区| 日韩精品无码一本二本三本色| 国产一区丝袜高跟鞋| 性欧美大战久久久久久久| 精品人妻无码专区中文字幕| 亚洲精品无码人妻无码| 中国大陆精品视频xxxx| 国产精品白丝喷水在线观看| 国产精品一区波多野结衣| 久久超碰极品视觉盛宴| 免费无码又爽又刺激高潮的视频| 亚洲国产成人精品久久久| 国产亚洲aⅴ在线电影| 久久久精品人妻一区二区三区四| 免费视频欧美无人区码|