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  4. Recombinant Human Integrin alpha-11 (ITGA11), partial

Recombinant Human Integrin alpha-11 (ITGA11), partial

  • 中文名稱：
    人ITGA11重組蛋白
  • 貨號：
    CSB-YP891732HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ITGA11重組蛋白
  • 貨號：
    CSB-EP891732HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ITGA11重組蛋白
  • 貨號：
    CSB-EP891732HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ITGA11重組蛋白
  • 貨號：
    CSB-BP891732HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ITGA11重組蛋白
  • 貨號：
    CSB-MP891732HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    integrin a11; Integrin alpha 11; Integrin alpha-11; ITA11_HUMAN; ITGA11
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Integrin alpha-11/beta-1 is a receptor for collagen.
  • 基因功能參考文獻：
    1. ITGA11 is a highly promising target that is selectively overexpressed in myofibroblasts during fibrotic diseases and regulates myofibroblast differentiation and key phenotypic characteristics. PMID: 29147013
    2. By employing co-immunoprecipitation and confocal microscopy analysis we showed that integrin alpha11beta1 and protein disulfide isomerase (PDI) create complexes bounded by disulfide bonds. Using surface plasmon resonance we provide biochemical evidence that PDI can interact directly with integrin subunit alpha11. PMID: 29203246
    3. Using MDR and RF, the overall best classifier of lung cancer status were SNPs rs1799732 (DRD2), rs5744256 (IL-18), rs2306022 (ITGA11) with training accuracy of 0.6592 and a testing accuracy of 0.6572 and a cross-validation consistency of 10/10 with permutation testing P<0.0001 PMID: 27121382
    4. FGF2 may be redirecting fibroblasts towards an anti-fibrotic phenotype during wound healing by overriding TGFb1 mediated ITGA11 expression. PMID: 26403263
    5. glycated collagen in the cardiac interstitium triggers an autocrine TGF-beta2 signaling pathway that stimulates alpha11 integrin expression through Smad2/3 binding elements in the alpha11 integrin promoter PMID: 24962729
    6. Myometrium and uterine fibroids express ITGA11. PMID: 24520080
    7. Interactions between alpha11 integrins and the Smad-dependent TGF-beta2 signalling may contribute to the formation of pro-fibrotic myofibroblasts and the development of a fibrotic interstitium in diabetic cardiomyopathy. PMID: 22869616
    8. The disturbance of alpha11beta1 mediated interactions to collagen I results in a tremendous reduction of hMSC numbers owing to mitochondrial leakage accompanied by Bcl-2-associated X protein upregulation. PMID: 21796158
    9. Data show that the 3 kb alpha11 promoter contains most of the regulatory elements that direct ectomesenchymal and mesodermal fibroblast-specific expression. PMID: 19913614
    10. Major transcription start site mapped. A core promoter [nt (-)127-(+)25], a potential silencer region [nt (-)400-(-)127] and a potential enhancer region [nt (-)1519-(-)400] identified as important for alpha11 transcription in mesenchymal cells. PMID: 12392762
    11. the GFOGER sequence in fibrillar collagens is a common recognition motif used by integrins, particularly alpha11beta1 PMID: 12496264
    12. A new interferon stimulated gene. (Integrin alpha 11) PMID: 16697656
    13. Through interaction between matrix collagen and stromal fibroblasts, integrin alpha 11 stimulates cancer cell growth. PMID: 17600088
    14. analysis of a prokaryotic Scl1 collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1 PMID: 18990704
    15. is a major collagen receptor on human periodontal ligament cells [and plays] a role in collagen lattice remodeling [ITGA11B1] PMID: 19641149

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin alpha chain family
  • 組織特異性：
    According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small i
  • 數據庫鏈接：

    HGNC: 6136

    OMIM: 604789

    KEGG: hsa:22801

    STRING: 9606.ENSP00000327290

    UniGene: Hs.436416



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