在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ITGA11 Antibody

  • 中文名稱:
    ITGA11兔多克隆抗體
  • 貨號:
    CSB-PA108283
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA108283(ITGA11 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA108283(ITGA11 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    integrin a11 antibody; Integrin alpha 11 antibody; Integrin alpha-11 antibody; ITA11_HUMAN antibody; ITGA11 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human ITGA11
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Integrin alpha-11/beta-1 is a receptor for collagen.
  • 基因功能參考文獻:
    1. ITGA11 is a highly promising target that is selectively overexpressed in myofibroblasts during fibrotic diseases and regulates myofibroblast differentiation and key phenotypic characteristics. PMID: 29147013
    2. By employing co-immunoprecipitation and confocal microscopy analysis we showed that integrin alpha11beta1 and protein disulfide isomerase (PDI) create complexes bounded by disulfide bonds. Using surface plasmon resonance we provide biochemical evidence that PDI can interact directly with integrin subunit alpha11. PMID: 29203246
    3. Using MDR and RF, the overall best classifier of lung cancer status were SNPs rs1799732 (DRD2), rs5744256 (IL-18), rs2306022 (ITGA11) with training accuracy of 0.6592 and a testing accuracy of 0.6572 and a cross-validation consistency of 10/10 with permutation testing P<0.0001 PMID: 27121382
    4. FGF2 may be redirecting fibroblasts towards an anti-fibrotic phenotype during wound healing by overriding TGFb1 mediated ITGA11 expression. PMID: 26403263
    5. glycated collagen in the cardiac interstitium triggers an autocrine TGF-beta2 signaling pathway that stimulates alpha11 integrin expression through Smad2/3 binding elements in the alpha11 integrin promoter PMID: 24962729
    6. Myometrium and uterine fibroids express ITGA11. PMID: 24520080
    7. Interactions between alpha11 integrins and the Smad-dependent TGF-beta2 signalling may contribute to the formation of pro-fibrotic myofibroblasts and the development of a fibrotic interstitium in diabetic cardiomyopathy. PMID: 22869616
    8. The disturbance of alpha11beta1 mediated interactions to collagen I results in a tremendous reduction of hMSC numbers owing to mitochondrial leakage accompanied by Bcl-2-associated X protein upregulation. PMID: 21796158
    9. Data show that the 3 kb alpha11 promoter contains most of the regulatory elements that direct ectomesenchymal and mesodermal fibroblast-specific expression. PMID: 19913614
    10. Major transcription start site mapped. A core promoter [nt (-)127-(+)25], a potential silencer region [nt (-)400-(-)127] and a potential enhancer region [nt (-)1519-(-)400] identified as important for alpha11 transcription in mesenchymal cells. PMID: 12392762
    11. the GFOGER sequence in fibrillar collagens is a common recognition motif used by integrins, particularly alpha11beta1 PMID: 12496264
    12. A new interferon stimulated gene. (Integrin alpha 11) PMID: 16697656
    13. Through interaction between matrix collagen and stromal fibroblasts, integrin alpha 11 stimulates cancer cell growth. PMID: 17600088
    14. analysis of a prokaryotic Scl1 collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1 PMID: 18990704
    15. is a major collagen receptor on human periodontal ligament cells [and plays] a role in collagen lattice remodeling [ITGA11B1] PMID: 19641149

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Integrin alpha chain family
  • 組織特異性:
    According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small i
  • 數據庫鏈接:

    HGNC: 6136

    OMIM: 604789

    KEGG: hsa:22801

    STRING: 9606.ENSP00000327290

    UniGene: Hs.436416



主站蜘蛛池模板: 97熟女毛毛多熟妇人妻aⅴ| 精品久久久久久无码不卡| 精品偷拍被偷拍在线观看| 欧美性猛少妇xxxxx免费 | 亚洲精品一线二线三线区别大吗| 久久精品无码一区二区www| 亚洲成av人影院| 给我免费的视频在线观看| 亚洲精品成人老司机影视| 国产一卡2卡3卡四卡精品app| 亚洲精品www久久久| 浴室人妻的情欲hd三级| 黑人巨大无码中文字幕无码| 国内久久婷婷六月综合欲色啪| www插插插无码免费视频网站| 好吊妞无缓冲视频观看| 免费无码又爽又刺激高潮的动态图| av天堂午夜精品蜜臀av| 天天躁日日躁狠狠躁av麻豆男男| av无码小缝喷白浆在线观看| 亚洲欧洲自拍拍偷精品网| 亚洲旡码欧美大片| 亚洲字幕av一区二区三区四区| 成人国产网站v片免费观看| 欧洲美洲精品一区二区三区| 天堂www中文资源| 午夜精品久久久久久久喷水| 日韩一本之道一区中文字幕| 人妻护士在线波多野结衣| 国产高清色高清在线观看| 亚洲色大成网站www尤物| 牲欲强的熟妇农村老妇女视频| 国产精品久久人妻无码网站蜜臀| 免费床视频大全叫不停欧美| 亚洲国产成人久久综合一区| 亚洲aⅴ在线无码天堂777| 久久66热人妻偷产精品9| 国产美女在线精品免费观看网址| 中国熟妇牲交视频| 青青草国产三级精品三级 | 成年女人免费视频播放体验区 |