在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Inositol-tetrakisphosphate 1-kinase (ITPK1)

  • 中文名稱:
    人ITPK1重組蛋白
  • 貨號:
    CSB-YP613412HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人ITPK1重組蛋白
  • 貨號:
    CSB-EP613412HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人ITPK1重組蛋白
  • 貨號:
    CSB-EP613412HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人ITPK1重組蛋白
  • 貨號:
    CSB-BP613412HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人ITPK1重組蛋白
  • 貨號:
    CSB-MP613412HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    3; 4)P(3) 5/6-kinase; 4-trisphosphate 5/6-kinase; Inositol 1 3 4 triphosphate 5/6 kinase; Inositol 1 3 4 trisphosphate 5/6 kinase; Inositol 1; Inositol tetrakisphosphate 1 kinase; Inositol triphosphate 5/6 kinase; Inositol-tetrakisphosphate 1-kinase; Inositol-triphosphate 5/6-kinase; Ins(1 3 4)P(3) 5/6 kinase; Ins(1; ITPK 1; itpk1; ITPK1_HUMAN; ITRPK 1; ITRPK1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-414
  • 氨基酸序列
    MQTFLKGKRV GYWLSEKKIK KLNFQAFAEL CRKRGMEVVQ LNLSRPIEEQ GPLDVIIHKL TDVILEADQN DSQSLELVHR FQEYIDAHPE TIVLDPLPAI RTLLDRSKSY ELIRKIEAYM EDDRICSPPF MELTSLCGDD TMRLLEKNGL TFPFICKTRV AHGTNSHEMA IVFNQEGLNA IQPPCVVQNF INHNAVLYKV FVVGESYTVV QRPSLKNFSA GTSDRESIFF NSHNVSKPES SSVLTELDKI EGVFERPSDE VIRELSRALR QALGVSLFGI DIIINNQTGQ HAVIDINAFP GYEGVSEFFT DLLNHIATVL QGQSTAMAAT GDVALLRHSK LLAEPAGGLV GERTCSASPG CCGSMMGQDA PWKAEADAGG TAKLPHQRLG CNAGVSPSFQ QHCVASLATK ASSQ
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis.
  • 基因功能參考文獻:
    1. The results suggested that the maternal rs3783903 of ITPK1 might be associated with spina bifida, and the allele G of rs3783903 might affect the binding of AP-1 and the decrease of maternal plasma inositol hexakisphosphate concentration. PMID: 24465924
    2. Activation of PLC by an endogenous cytokine (GBP) in Drosophila S3 cells and its application as a model for studying inositol phosphate signalling through ITPK1. PMID: 22928859
    3. HEK293 cells stably expressing acetylated ITPK1 had reduced levels of the higher phosphorylated forms of inositol, compared with the levels seen in cells expressing unacetylated ITPK1 PMID: 22308441
    4. 5/6-kinase modifies TNFalpha-induced apoptosis by interfering with the activation of TNF-R1-associated death domain PMID: 12925536
    5. analysis of inositol phosphate signaling pathway integration via human ITPK1 PMID: 17616525

    顯示更多

    收起更多

  • 蛋白家族:
    ITPK1 family
  • 組織特異性:
    Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen.
  • 數據庫鏈接:

    HGNC: 6177

    OMIM: 601838

    KEGG: hsa:3705

    STRING: 9606.ENSP00000267615

    UniGene: Hs.308122



主站蜘蛛池模板: 俺去俺来也www色官网| 国产精品自产拍在线18禁| 国产精品成人免费999| 人妻精品动漫h无码网站| 2020国产激情视频在线观看 | 精品国产av一区二区果冻传媒| 国产大陆亚洲精品国产| 国产天美传媒性色av| 极品尤物被啪到呻吟喷水| 亚洲aⅴ永久无码一区二区三区| 蜜臀视频一区二区在线播放 | 夜夜躁狠狠躁2021| 亚洲无av码在线中文字幕| 亚洲国产精品自在拍在线播放蜜臀 | 日本丰满人妻xxxxxhd| 国产人妖乱国产精品人妖| 亚洲一区二区三区成人网站| 曰本无码不卡高清av一二| 日本熟妇美熟bbw| 亚洲6080yy久久无码产自国产 | 精品欧美小视频在线观看| 色婷婷综合缴情综免费观看| 熟妇的味道hd中文字幕| 国产大屁股视频免费区 | 青乐娱精品视频一国产分类| 成人av无码国产在线观看| 色综合久久蜜芽国产精品| 国产综合精品久久丫| 久久人人超碰精品caoporen| 正在播放国产剧情亂倫| 好吊妞视频这里有精品| 亚洲色欲www综合网| 精品av中文字幕在线毛片| 日本精品aⅴ一区二区三区| 久久av高清无码| 亚洲人成亚洲精品| 国产无遮挡又爽又黄大胸免费| 人人莫人人擦人人看| 亚洲欧洲中文日韩久久av乱码| 少妇厨房愉情理伦bd在线观看| 无码人妻精品一区二区三区免费 |