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ITPK1

Inositol-tetrakisphosphate 1-kinase is a protein in humans that is encoded by ITPK1 gene. Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

ITPK1 Antibodies

ITPK1 for Homo sapiens (Human)

ITPK1 Proteins

ITPK1 Proteins for Bos taurus (Bovine)

ITPK1 Proteins for Homo sapiens (Human)

ITPK1 Proteins for Gallus gallus (Chicken)

ITPK1 Proteins for Xenopus laevis (African clawed frog)

ITPK1 Proteins for Zea mays (Maize)

ITPK1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

ITPK1 Proteins for Mus musculus (Mouse)

ITPK1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

ITPK1 Proteins for Entamoeba histolytica



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