在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Importin-8 (IPO8), partial

Recombinant Human Importin-8 (IPO8), partial

  • 中文名稱：
    人IPO8重組蛋白
  • 貨號：
    CSB-YP011780HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人IPO8重組蛋白
  • 貨號：
    CSB-EP011780HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人IPO8重組蛋白
  • 貨號：
    CSB-EP011780HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人IPO8重組蛋白
  • 貨號：
    CSB-BP011780HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人IPO8重組蛋白
  • 貨號：
    CSB-MP011780HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    IPO8
  • Uniprot No.：
  • 別名：
    FLJ26580; Imp 8; Imp8; Importin-8; Importin8; IPO 8; IPO8; IPO8_HUMAN; Ran binding protein 8; RAN BP8; Ran-binding protein 8; RANBP 8; RanBP8
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.
  • 基因功能參考文獻：
    1. the findings of the present study provided novel insights into the control of IPO8 transcription, and may enhance understanding regarding RUNX2 regulatory mechanisms in osteoblast differentiation, bone development, and degenerative bone disease. PMID: 27277970
    2. Our studies also suggest that nuclear entry is important for the prooncogenic activity of eIF4E, at least in this context. These findings position nuclear trafficking of eIF4E as a critical step in its regulation and position the importin 8-eIF4E complex as a novel therapeutic target. PMID: 27114554
    3. importin alpha8 functions as a cNLS receptor with distinct cargo specificity, and that heterodimerization by importin alpha8 is a novel regulatory mode of cNLS binding, in addition to the autoinhibitory regulation by the importin beta binding domain. PMID: 26220098
    4. Knockdown of IPO8 reduced the amount of nuclear p65 following TNF stimulation. IPO8 binding to p65 is NLS independent. PMID: 23906023
    5. TGF-beta-induced and basal state spontaneous nuclear import of Smad4 require importin 7 and 8. PMID: 18519565
    6. IPO8 is the most accurate reference gene for clinical lung specimens. PMID: 19014639
    7. Study provides evidence that Imp8 is required for cytoplasmic miRNA-guided gene silencing and affects nuclear localization of Ago proteins. PMID: 19167051

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Importin beta family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9853

    OMIM: 605600

    KEGG: hsa:10526

    STRING: 9606.ENSP00000256079

    UniGene: Hs.505136



主站蜘蛛池模板： 亚洲啪av永久无码精品放毛片| 亚洲熟女精品中文字幕| 国产极品美女到高潮无套| 亚洲国产精品无码久久久蜜芽| 毛片内射-百度| 国产乡下妇女做爰| 一本久道高清无码视频| 饥渴少妇做私密保健视频| 国产98在线 | 免费| 免费人成视频在线播放| b站永久免费看片大全| 丰满日韩放荡少妇无码视频| 欧美老妇乱辈通奷| 国产无遮挡吃胸膜奶免费看| 99视频在线精品免费观看6| 2020年最新国产精品正在播放| 亚洲aⅴ综合av国产八av| 精品久久久久中文字幕一区| 国产精品你懂的在线播放| 亚洲精品国产情侣av在线| 国产 制服丝袜 动漫在线| 人妻 色综合网站| 久久久亚洲色| 欧美精品a∨在线观看| 日本一区二区三区免费高清 | 国产av综合影院| 爽爽午夜影视窝窝看片| 四虎精品免费永久免费视频| 香蕉av777xxx色综合一区| 少妇邻居内射在线| 亚洲成年网站青青草原 | 脱了美女内裤猛烈进入gif| 亚洲高清无在码在线电影| 亚洲自偷自拍另类12p| 亚洲熟女www一区二区三区| 日韩精品久久久久久久电影蜜臀| 纯肉无遮挡无码日本动漫| 国产高清在线精品一区二区三区| 国产天美传媒性色av| 国产欧美日韩一区2区| 丝袜高潮流白浆潮喷在线播放 |