在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Homeobox protein Hox-D10 (HOXD10)

Recombinant Human Homeobox protein Hox-D10 (HOXD10)

  • 中文名稱：
    人HOXD10重組蛋白
  • 貨號：
    CSB-YP010682HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HOXD10重組蛋白
  • 貨號：
    CSB-EP010682HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HOXD10重組蛋白
  • 貨號：
    CSB-EP010682HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HOXD10重組蛋白
  • 貨號：
    CSB-BP010682HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HOXD10重組蛋白
  • 貨號：
    CSB-MP010682HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXD10
  • Uniprot No.：
  • 別名：
    AI385591; AI874987; Homeo box 4D; Homeo box D10 ; Homeobox D10; Homeobox protein Hox-4D; Homeobox protein Hox-4E; Homeobox protein Hox-D10; Hox 4.4; Hox 4.5; Hox 4D ; Hox 4E ; Hox 5.3; HOX4D ; HOX4E; HOXD10; HXD10; HXD10_HUMAN; OTTMUSP00000017845; RP23-313J15.9
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-340
  • 氨基酸序列
    MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT CGLLPSLAKR EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT CSFTTNIKEE SNCCMYSDKR NKLISAEVPS YQRLVPESCP VENPEVPVPG YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL NPRGAAKPQL SAAQLQMEKK MNEPVSGQEP TKVSQVESPE AKGGLPEERS CLAEVSVSSP EVQEKESKEE IKSDTPTSNW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS KSVNLTDRQV KIWFQNRRMK LKKMSRENRI RELTANLTFS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能參考文獻：
    1. Results show that HOXD10 promoter is hypermethylated in papillary thyroid cancer (PTC) tissues and its mRNA expression decreased. Moreover, the hypermethylation of HOXD10 was associated with invasion of the primary tumor. Further data provide evidence that the epigenetic suppression of the HOXD10 gene may play a role in the tumorigenesis of PTC. PMID: 29115628
    2. Results show that HOXD10 is frequently methylated in human hepatocellular carcinoma (HCC), and the expression of HOXD10 is regulated by promoter region methylation. HOXD10 suppresses HCC cell growth both in vitro and in vivo. HOXD10 suppresses human HCC by inhibiting ERK signaling. PMID: 29075359
    3. our data suggest that the loss of HoxD10 function is common and may thus result in a progressive phenotype in PCa. HoxD10 may function as a biomarker that differentiates patients with BCR disease from the ones that are not after radical prostatectomy, implicating its potential as a therapeutic target. PMID: 28231752
    4. Knock down of the dickkopf WNT signaling pathway inhibitor 2 (DKK2) resulted in a significant suppression of HOXD10, HOXD11 and HOXD13 while over-expression of DKK2 and stimulation with factors of the WNT signaling pathway. PMID: 27363011
    5. By treating LECs with VEGF-C156S and analyzing subsequent changes in gene expression, we identified several 'immediate early' transcription factors that showed a rapid transient upregulation VEGFR-3 stimulation. these results reveal an important and unanticipated role of HOXD10 in the regulation of VEGFR-3 signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability. PMID: 27199372
    6. Knockdown of HOXD10 in renal cells also resulted in increased resistance to colistin cytotoxicity. PMID: 28335481
    7. High expression of HOXD10 is associated with laryngeal squamous cell carcinoma. PMID: 27658780
    8. Low HOXD10 promotes migration and invasion in gastric cancer. PMID: 26311318
    9. These results suggested that HOXD10 may be a putative suppressor gene and can act as a prognostic marker and potentially a novel therapeutic target for cholangiocellular carcinoma. PMID: 26260613
    10. miR-23a was upregulated in glioma. This overexpression promoted glioma cell invasion, probably by modulating MMP-14 via directly inhibiting the expression of HOXD10. PMID: 24305689
    11. POU2F1 activity regulates HOXD10 and HOXD11 gene expression in head and neck squamous cell carcinoma, promoting a proliferative and invasive phenotype. PMID: 25301728
    12. Downregulation of the HOXD10 gene expression was associated with breast cancer. PMID: 25081374
    13. KLF4 and HOXD10 were identified as direct targets of miR-10b in bladder cancer cells PMID: 24573354
    14. It is a member of the HOX gene family. HOX genes are the main regulatory genes that directly influence organogenesis and maintain the function of differentiated tissues PMID: 24219032
    15. MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration. PMID: 24376640
    16. HOXD10 expression varies by stage of disease and produces differential effects in head and neck squamous cell carcinoma. PMID: 25010866
    17. TBX1 can alter TGF-beta/BMP, an important signaling pathway, through interacting with HOXD10. Above findings may shed light on the mechanism of TBX1 mutations leading to renal malformations found in patients carrying a 22q11 deletion. PMID: 22842189
    18. downregulation of HOXD10 expression by miR-10b overexpression may induce an increase of pro-metastatic gene products, such as MMP14 and RHOC, and contribute to the acquisition of metastatic phenotypes in epithelial ovarian cancer cells PMID: 23670532
    19. HoxD10 potentially functions as a tumor suppressor that is inactivated through promoter hypermethylation in gastric cancer. PMID: 22160393
    20. Suggest that miR-10b can stimulate the upregulation of RhoC and AKT phosphorylation through targeting HOXD10, thus promoting cell invasion in gastric tumors. PMID: 22293682
    21. miR-10b induced glioma cell invasion by modulating tumor invasion factors MMP-14 and uPAR expression via the direct target HOXD10 PMID: 21419107
    22. results indicate a role for HoxD10 in maintaining a nonangiogenic state in the endothelium PMID: 12466126
    23. Missense Mutation in HOXD10 is associated with congenital vertical talus and Charcot-Marie-Tooth disease PMID: 15146389
    24. An autosomal-dominant-inherited mutation in a HOXD10 gene with complete penetrance is found in all members of a pedigree with congenital vertical talus. PMID: 15368082
    25. No evidence was found of linkage near the HOXD gene cluster on chromosome 2q, suggesting genes other than HOXD10 are responsible for idiopathic clubfoot. PMID: 17417092
    26. Pak1 is a target of miR-7 and that HoxD10 plays a regulatory role in modifying the expression of miR-7. PMID: 18922890

    顯示更多

    收起更多

  • 相關疾病：
    Vertical talus, congenital (CVT)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 組織特異性：
    Strongly expressed in the adult male and female urogenital tracts.
  • 數據庫鏈接：

    HGNC: 5133

    OMIM: 142984

    KEGG: hsa:3236

    STRING: 9606.ENSP00000249501

    UniGene: Hs.123070



主站蜘蛛池模板： 亚洲人成人无码www影院| 一本大道久久香蕉成人网| 欧美黑人巨大videos极品| 人妻少妇久久中文字幕| 人妻无码久久精品人妻| 又色又污又爽又黄的网站| 成人毛片av免费| 四虎成人精品永久在线视频| 性生交大片免费看女人按摩| 性xxxx欧美老妇胖老太269| 最近中文字幕免费大全在线| 久久精品超碰av无码| 无码av一区二区三区无码| 国产av激情无码久久| 2019亚洲午夜无码天堂| 中文字幕无线观看中文字幕| 日本中文字幕有码在线视频| 成人亚洲a片v一区二区三区日本 | 一性一交一口添一摸视频| 欧美专区日韩视频人妻| 国产成人综合久久免费| 亚洲欧洲精品成人久久曰| 亚洲欧洲av综合色无码| 亚洲成在人线a免费77777| 亚洲人成图片小说网站| 久久午夜福利无码1000合集| 蜜臀av国产一区二区三区| 99热网址最新获取域名| 国产农村老太xxxxhdxx| 国产精品美女www爽爽爽视频 | 黑人巨大白妞出浆| 日本特黄特色aaa大片免费| 精品一区二区三区在线观看视频| 日本欧美一区二区三区在线播放| 免费的av网站手机版| 亚洲精品第一国产综合野草社区 | 特黄做受又大又粗又长大片| 亚洲一区二区三区国产精品无码 | 国产成人免费无码视频在线观看 | 久久99久久99小草精品免视看| 上海少妇高潮狂叫喷水了|