在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Histidine triad nucleotide-binding protein 2, mitochondrial (HINT2)

Recombinant Human Histidine triad nucleotide-binding protein 2, mitochondrial (HINT2)

  • 中文名稱：
    人HINT2重組蛋白
  • 貨號：
    CSB-YP880123HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HINT2重組蛋白
  • 貨號：
    CSB-EP880123HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HINT2重組蛋白
  • 貨號：
    CSB-EP880123HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HINT2重組蛋白
  • 貨號：
    CSB-BP880123HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HINT2重組蛋白
  • 貨號：
    CSB-MP880123HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HINT2
  • Uniprot No.：
  • 別名：
    1190005L05Rik; HINT-2; HINT-3; HINT2; HINT2_HUMAN; histidine triad nucleotide binding protein 2; Histidine triad nucleotide-binding protein 2; HIT-17 ; HIT-17kDa; mitochondrial; PKCI-1-related HIT protein; Protein kinase C inhibitor 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    18-163
  • 氨基酸序列
    VAA TGVRGGQVRG AAGVTDGNEV AKAQQATPGG AAPTIFSRIL DKSLPADILY EDQQCLVFRD VAPQAPVHFL VIPKKPIPRI SQAEEEDQQL LGHLLLVAKQ TAKAEGLGDG YRLVINDGKL GAQSVYHLHI HVLGGRQLQW PPG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2. Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro. May be involved in steroid biosynthesis. May play a role in apoptosis.
  • 基因功能參考文獻：
    1. Authors deduced that HINT2 triggers apoptosis in pancreatic cancer cells by regulating mitochondrial Ca(2+) influx through the mitochondrial calcium uniporter (MCU). Authors found that HINT2 can sensitize BxPC-3 and L3.6pl cells to gemcitabine-induced apoptosis and that gemcitabine up-regulates HINT2 expression. PMID: 28947137
    2. HINT2 downregulation depended on hypoxia inducible factor (HIF)-2alpha-mediated transcriptional activation of zinc finger E-box-binding homeobox 1 (ZEB1). These results suggest that HINT2 downregulation promotes HIF-2alpha expression, which induces EMT and enhances CRC cell migration and invasion. PMID: 28088787
    3. Low HINT2 expression is associated with low response to therapy in endometrial cancer. PMID: 23682076
    4. X-ray crystal structure of human HINT2 with and without bound AMP. PMID: 23659632
    5. Hint2 is required for an optimal steroidogenic response, possibly because of a particular signalling function exerted within the mitochondria. PMID: 18653718

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    HINT family
  • 組織特異性：
    High expression in liver and pancreas. Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.
  • 數據庫鏈接：

    HGNC: 18344

    OMIM: 609997

    KEGG: hsa:84681

    STRING: 9606.ENSP00000259667

    UniGene: Hs.70573



主站蜘蛛池模板： 欧美交a欧美精品喷水| 久久国产精品久久久久久| 性史性农村dvd毛片| 日本免费视频| 四虎成人精品在永久免费| 国产1卡二卡3卡四卡乱码视频| 久久人人97超碰caoporen| 国产成人无码aa精品一区| 久久99国产亚洲高清观看首页| 乱人伦中文视频在线| 亚洲—本道 在线无码av发| 最近中文字幕mv在线视频看 | 国产亚洲精品久久无码98| 97精品人人妻人人| 日韩一区二区三区精品| 粉嫩被粗大进进出出视频| 亚洲色欲av无码成人专区| 人人入人人爱| 中文无码一区二区不卡av| 伊人无码精品久久一区二区| 欧美国产日韩a欧美在线观看 | 97碰碰碰人妻无码视频| 国产女人爽的流水毛片| 欧美成人一卡二卡三卡四卡 | 亚洲成a∧人片在线播放无码 | 国产午夜鲁丝片av无码| 亚洲色偷拍另类无码专区| 免费一本色道久久一区| 99精品国产在热久久无毒| 国产精品成人精品久久久| 久久久久久国产精品无码超碰| 国内精品伊人久久久久影院对白| 韩国主播av福利一区二区| 久久久久成人精品免费播放动漫| 日日碰狠狠躁久久躁2023| 久久精品无码专区免费青青| 波多野结衣一区二区三区av免费| 一本大道伊人av久久乱码| 成人国产三级在线观看| 少妇高潮惨叫久久久久电影| 国产精品久久久午夜夜伦鲁鲁|