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  4. HINT2 Antibody

HINT2 Antibody

  • 中文名稱：
    HINT2兔多克隆抗體
  • 貨號：
    CSB-PA239614
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA239614(HINT2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    HINT2
  • 別名：
    1190005L05Rik antibody; HINT-2 antibody; HINT-3 antibody; HINT2 antibody; HINT2_HUMAN antibody; histidine triad nucleotide binding protein 2 antibody; Histidine triad nucleotide-binding protein 2 antibody; HIT-17 antibody; HIT-17kDa antibody; mitochondrial antibody; PKCI-1-related HIT protein antibody; Protein kinase C inhibitor 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human HINT2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:10-1:50
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2. Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro. May be involved in steroid biosynthesis. May play a role in apoptosis.
  • 基因功能參考文獻：
    1. Authors deduced that HINT2 triggers apoptosis in pancreatic cancer cells by regulating mitochondrial Ca(2+) influx through the mitochondrial calcium uniporter (MCU). Authors found that HINT2 can sensitize BxPC-3 and L3.6pl cells to gemcitabine-induced apoptosis and that gemcitabine up-regulates HINT2 expression. PMID: 28947137
    2. HINT2 downregulation depended on hypoxia inducible factor (HIF)-2alpha-mediated transcriptional activation of zinc finger E-box-binding homeobox 1 (ZEB1). These results suggest that HINT2 downregulation promotes HIF-2alpha expression, which induces EMT and enhances CRC cell migration and invasion. PMID: 28088787
    3. Low HINT2 expression is associated with low response to therapy in endometrial cancer. PMID: 23682076
    4. X-ray crystal structure of human HINT2 with and without bound AMP. PMID: 23659632
    5. Hint2 is required for an optimal steroidogenic response, possibly because of a particular signalling function exerted within the mitochondria. PMID: 18653718

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  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    HINT family
  • 組織特異性：
    High expression in liver and pancreas. Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.
  • 數據庫鏈接：

    HGNC: 18344

    OMIM: 609997

    KEGG: hsa:84681

    STRING: 9606.ENSP00000259667

    UniGene: Hs.70573



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