在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Histamine H3 receptor (HRH3)-VLPs

  • 中文名稱:
    人HRH3重組蛋白
  • 貨號:
    CSB-MP897568HU
  • 規格:
    ¥5250
  • 圖片:
    • CSB-MP897568HU is detected by Mouse anti-6*His monoclonal antibody.
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    Mammalian cell
  • 分子量:
    50.0 kDa
  • 表達區域:
    1-445aa
  • 氨基酸序列
    MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged(This tag can be tested only under denaturing conditions)
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile  water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃.
    Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store the protein at -20°C/-80°C upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
  • 基因功能參考文獻:
    1. These results indicate that in SH-SY5Y cells, hH3R445 and hH3R365 isoforms regulate in a differential manner the signaling pathways triggered by receptor activation. PMID: 29557708
    2. results indicate that the single-point Y197C mutation, in the aminus region of TM5 of the hH3R445, does not affect the expression, ligand binding or signaling of the receptor PMID: 28126588
    3. We detected high H3R expression in oligodendroglial cells from demyelination lesions in human samples of patients with MS, and validated a genetic association between an exonic single nucleotide polymorphism in HRH3 and susceptibility to multiple sclerosis. PMID: 29253893
    4. These findings for the first time screen out one SNP (rs3787429) of HRH3 gene that was significantly associated with CHF in Chinese Han population PMID: 26989676
    5. Decrease in histamine H3 receptor function was linked to epileptic activity in the hippocampus and temporal neocortex of patients with pharmacoresistant mesial temporal lobe epilepsy. PMID: 26915454
    6. Molecular modelling studies, including molecular dynamic simulations and calculation of Gibbs energy of solvation of hH3R and hH4R, were studied. PMID: 25098339
    7. The polymorphisms of HNMT and HRH3 were irrelevant with breast cancer in the present study. PMID: 24835231
    8. the anatomical localization of Hreceptors suggests a complex interaction that could both enhance and inhibit dopaminergic neurotransmission; tt is conceivable that Hreceptors can moderate the development and maintenance of drug addiction. PMID: 23647606
    9. The A280V mutation reduces the signalling efficacy of the human H3 receptor; this effect may be relevant to the pathophysiology of disorders associated with the mutation PMID: 23713487
    10. Report synthesis/functional characterization of imbutamine analogs as histamine H3 agonists. PMID: 24493592
    11. In this review, we focus on the role of histamine and its receptors in the treatment of Alzheimer's disease. PMID: 23677734
    12. [review] The H1, H2, and H3 receptors are all involved in recovery of neurological function when extracellular histamine is gradually increasing, after cerebral ischemia. PMID: 22860191
    13. mRNA expression of HRH-3 localized in large pigmented neurons is significantly decreased in the substantia nigra of Parkinson's patients. PMID: 22118942
    14. ZEL-H16 is a novel and potent nonimidazole agonist of H3R, which might serve as a pharmacological tool for future investigations or as possible therapeutic agent of H3R. PMID: 22870296
    15. Significant association of HRH3 with antipsychotic efficacy was detected. PMID: 21652606
    16. study identified novel functional properties in terms of voltage sensitivities and deactivation rates, which differed between the histamine hH3445, hH3365, and H4 receptors PMID: 22885137
    17. Histamine H3 receptor levels are unchanged in subcortical ischemic vascular dementia and mixed dementias in all brain areas studied. PMID: 22129936
    18. The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H(3) receptor are involved in receptor-G-protein coupling. PMID: 21749919
    19. Data suggest that V-allele genotypes in the H3 receptor gene increase inactive receptors, enhancing inhibition of negative feedback mechanism on the H3 receptor and increasing histamine release, correlating with migraine attacks in susceptible patients. PMID: 21376262
    20. This review outlines the relevance of the histaminergic system in controlling feeding behavior and evaluates the potential role of the histamine H3 receptor as a target for regulating obesity. PMID: 20864503
    21. Modulation of PKCalpha by histamine receptors may be important in regulating cholangiocarcinoma growth. PMID: 19825989
    22. Analogous to the effects of alpha(2)-adrenoceptors, which also act prejunctionally to inhibit norepinephrine release, H(3)R-mediated antiexocytotic effects could result from a decreased Ca(2+) influx into nerve endings PMID: 11752397
    23. The structure of HRH3 has been determined and a missense mutation (Ala280Val) identified in a patient with Shy-Drager syndrome. PMID: 11956964
    24. Molecular cloning of functionally distinct isoforms of the human histamine H(3) receptor PMID: 12069903
    25. Densities of histamine H(3) receptor sites were significantly decreased in patient material. PMID: 12971961
    26. absence of H3 receptor in human skin mast cells PMID: 15191551
    27. The human H(3)receptor gene suggested to consist of either 3 exons and 2 introns, or 4 exons and 3 introns, with ...additional exon accounting for...8 additional carboxy(C)-terminal amino acids...in some human H(3) receptor sequences PMID: 15665857
    28. we describe the biological and chemical implications for developing H3 receptor antagonists and their therapeutic potential as disclosed through animal models of cognition, sleep, and obesity. PMID: 16565470
    29. The purpose of this study was to identify the structural requirements for H3 antagonistic activity via quantitative structure-activity relationship (QSAR) studies and receptor modeling/docking techniques. PMID: 17561422
    30. Histamine excites human enteric neurones and this effect involves histamine H1-4 receptors. PMID: 17627982
    31. Data show that histamine regulates pancreatic carcinoma cell growth through H3 and H4 receptors. PMID: 18345506
    32. H(3)R is localized mainly around submucosal glands and plays an important role in the secretion of submucosal glands in the nose. PMID: 18564330
    33. role in neurogenic inflammation PMID: 18802338
    34. D1-H3 receptor heteromers constitute unique devices that can direct dopaminergic and histaminergic signalling towards the MAPK pathway in a G(s)-independent and G(i)-dependent manner. PMID: 19413572
    35. Histamine H3 receptors in the prefrontal cortex take part in the modulation of cognition, which is impaired in schizophrenic subjects and bipolar subjects with psychotic symptoms. PMID: 19413576

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are
  • 數據庫鏈接:

    HGNC: 5184

    OMIM: 604525

    KEGG: hsa:11255

    STRING: 9606.ENSP00000342560

    UniGene: Hs.251399



主站蜘蛛池模板: 无码国产一区二区三区四区| 夫妇交换性三中文字幕| 天堂а√在线中文在线| 香港日本三级亚洲三级| 亚洲精品国产美女久久久| 免费无码又爽又刺激毛片| 亚洲欧美乱综合图片区小说区 | 韩国日本三级在线观看| 国产亚洲美女精品久久久| 人人妻人人澡人人爽国产| 国产一区二区亚洲精品| 爽到高潮无码视频在线观看| 欧美老熟妇乱子伦视频| 久久婷婷五月综合色国产香蕉| 丁香五月开心婷婷激情综合| 果冻传媒亚洲区二期| 午夜亚洲www湿好爽| 成人精品视频一区二区三区尤物| 国产成人欧美亚洲日韩电影| 天天摸夜夜摸夜夜狠狠添| 日本丰满熟妇hd| 中国大陆高清aⅴ毛片| 精品无码av一区二区三区| 精品av中文字幕在线毛片 | 男人用嘴添女人私密视频| 亚洲欧美成人片在线观看| 欧美性猛交xxxx乱大交蜜桃| 亚洲国产精品久久一线不卡| 蜜臀亚洲精品国产aⅴ综合第一| 国产精品一区在线蜜臀| 国产小受呻吟gv视频在线观看| 人妻少妇无码精品视频区| 亚洲久悠悠色悠在线播放| 熟女少妇人妻黑人sirbao| 亚洲人成人影院在线观看| 亚洲精品中文字幕乱码三区| 国产后进白嫩翘臀在线播放| 国产亚洲欧美日韩在线观看一区 | 亚洲自偷自偷偷色无码中文| 国产精品视频永久免费播放| 亚洲乱码卡一卡二卡新区豆|