在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Histamine H3 receptor (HRH3), partial

  • 中文名稱:
    人HRH3重組蛋白
  • 貨號:
    CSB-YP897568HU1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人HRH3重組蛋白
  • 貨號:
    CSB-EP897568HU1
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人HRH3重組蛋白
  • 貨號:
    CSB-EP897568HU1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人HRH3重組蛋白
  • 貨號:
    CSB-BP897568HU1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人HRH3重組蛋白
  • 貨號:
    CSB-MP897568HU1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    HRH3; GPCR97; Histamine H3 receptor; H3R; HH3R; G-protein coupled receptor 97
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
  • 基因功能參考文獻:
    1. These results indicate that in SH-SY5Y cells, hH3R445 and hH3R365 isoforms regulate in a differential manner the signaling pathways triggered by receptor activation. PMID: 29557708
    2. results indicate that the single-point Y197C mutation, in the aminus region of TM5 of the hH3R445, does not affect the expression, ligand binding or signaling of the receptor PMID: 28126588
    3. We detected high H3R expression in oligodendroglial cells from demyelination lesions in human samples of patients with MS, and validated a genetic association between an exonic single nucleotide polymorphism in HRH3 and susceptibility to multiple sclerosis. PMID: 29253893
    4. These findings for the first time screen out one SNP (rs3787429) of HRH3 gene that was significantly associated with CHF in Chinese Han population PMID: 26989676
    5. Decrease in histamine H3 receptor function was linked to epileptic activity in the hippocampus and temporal neocortex of patients with pharmacoresistant mesial temporal lobe epilepsy. PMID: 26915454
    6. Molecular modelling studies, including molecular dynamic simulations and calculation of Gibbs energy of solvation of hH3R and hH4R, were studied. PMID: 25098339
    7. The polymorphisms of HNMT and HRH3 were irrelevant with breast cancer in the present study. PMID: 24835231
    8. the anatomical localization of Hreceptors suggests a complex interaction that could both enhance and inhibit dopaminergic neurotransmission; tt is conceivable that Hreceptors can moderate the development and maintenance of drug addiction. PMID: 23647606
    9. The A280V mutation reduces the signalling efficacy of the human H3 receptor; this effect may be relevant to the pathophysiology of disorders associated with the mutation PMID: 23713487
    10. Report synthesis/functional characterization of imbutamine analogs as histamine H3 agonists. PMID: 24493592
    11. In this review, we focus on the role of histamine and its receptors in the treatment of Alzheimer's disease. PMID: 23677734
    12. [review] The H1, H2, and H3 receptors are all involved in recovery of neurological function when extracellular histamine is gradually increasing, after cerebral ischemia. PMID: 22860191
    13. mRNA expression of HRH-3 localized in large pigmented neurons is significantly decreased in the substantia nigra of Parkinson's patients. PMID: 22118942
    14. ZEL-H16 is a novel and potent nonimidazole agonist of H3R, which might serve as a pharmacological tool for future investigations or as possible therapeutic agent of H3R. PMID: 22870296
    15. Significant association of HRH3 with antipsychotic efficacy was detected. PMID: 21652606
    16. study identified novel functional properties in terms of voltage sensitivities and deactivation rates, which differed between the histamine hH3445, hH3365, and H4 receptors PMID: 22885137
    17. Histamine H3 receptor levels are unchanged in subcortical ischemic vascular dementia and mixed dementias in all brain areas studied. PMID: 22129936
    18. The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H(3) receptor are involved in receptor-G-protein coupling. PMID: 21749919
    19. Data suggest that V-allele genotypes in the H3 receptor gene increase inactive receptors, enhancing inhibition of negative feedback mechanism on the H3 receptor and increasing histamine release, correlating with migraine attacks in susceptible patients. PMID: 21376262
    20. This review outlines the relevance of the histaminergic system in controlling feeding behavior and evaluates the potential role of the histamine H3 receptor as a target for regulating obesity. PMID: 20864503
    21. Modulation of PKCalpha by histamine receptors may be important in regulating cholangiocarcinoma growth. PMID: 19825989
    22. Analogous to the effects of alpha(2)-adrenoceptors, which also act prejunctionally to inhibit norepinephrine release, H(3)R-mediated antiexocytotic effects could result from a decreased Ca(2+) influx into nerve endings PMID: 11752397
    23. The structure of HRH3 has been determined and a missense mutation (Ala280Val) identified in a patient with Shy-Drager syndrome. PMID: 11956964
    24. Molecular cloning of functionally distinct isoforms of the human histamine H(3) receptor PMID: 12069903
    25. Densities of histamine H(3) receptor sites were significantly decreased in patient material. PMID: 12971961
    26. absence of H3 receptor in human skin mast cells PMID: 15191551
    27. The human H(3)receptor gene suggested to consist of either 3 exons and 2 introns, or 4 exons and 3 introns, with ...additional exon accounting for...8 additional carboxy(C)-terminal amino acids...in some human H(3) receptor sequences PMID: 15665857
    28. we describe the biological and chemical implications for developing H3 receptor antagonists and their therapeutic potential as disclosed through animal models of cognition, sleep, and obesity. PMID: 16565470
    29. The purpose of this study was to identify the structural requirements for H3 antagonistic activity via quantitative structure-activity relationship (QSAR) studies and receptor modeling/docking techniques. PMID: 17561422
    30. Histamine excites human enteric neurones and this effect involves histamine H1-4 receptors. PMID: 17627982
    31. Data show that histamine regulates pancreatic carcinoma cell growth through H3 and H4 receptors. PMID: 18345506
    32. H(3)R is localized mainly around submucosal glands and plays an important role in the secretion of submucosal glands in the nose. PMID: 18564330
    33. role in neurogenic inflammation PMID: 18802338
    34. D1-H3 receptor heteromers constitute unique devices that can direct dopaminergic and histaminergic signalling towards the MAPK pathway in a G(s)-independent and G(i)-dependent manner. PMID: 19413572
    35. Histamine H3 receptors in the prefrontal cortex take part in the modulation of cognition, which is impaired in schizophrenic subjects and bipolar subjects with psychotic symptoms. PMID: 19413576

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are
  • 數據庫鏈接:

    HGNC: 5184

    OMIM: 604525

    KEGG: hsa:11255

    STRING: 9606.ENSP00000342560

    UniGene: Hs.251399



主站蜘蛛池模板: 免费看成人午夜福利专区| 欧美日韩精品一区二区性色a+v| 亚洲人成无码网站在线观看| 少妇人妻无码专区在线视频| 国产在线视频www色| 一本色道久久hezyo无码| 中文字幕亚洲无线码一区女同 | 久久综合伊人| 丁香五月亚洲综合在线| 精品国产美女av久久久久| 狠狠色丁香五月综合缴情婷婷五月| 日韩亚洲国产激情一区浪潮av| 日韩av无码中文无码不卡电影| 天天干天天日| 99久久免费国产精品四虎| 精品人成视频免费国产| 99re8这里有精品热视频免费| 国产suv精品一区二人妻| 亚洲一区二区制服在线| 亚洲欧美日韩国产自偷| 少妇激情一区二区三区视频小说| 老司机午夜免费精品视频| 亚洲精品综合在线影院| 狠狠做五月深爱婷婷| 欧美不卡一区二区三区| 2012中文字幕在线视频| 香港特级三a毛片免费观看| 欧美丰满美乳xxⅹ高潮www| 国产国拍亚洲精品av在线| 日本高清视频色wwwwww色| 岛国av无码免费无禁网站麦芽| 人妻无码精品久久亚瑟影视| 中文字幕乱码人妻综合二区三区| 亚洲女人自熨在线视频| 激情文学小说区另类小说同性| 性色av无码久久一区二区三区| 欧美丰满老熟妇xxxxx性| 在线天堂资源www在线中文| 国产在线视频一区二区三区98| 香港三级精品三级在线专区 | 大地资源网中文第五页|