在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human High mobility group protein B3 (HMGB3)

Recombinant Human High mobility group protein B3 (HMGB3)

  • 中文名稱：
    人HMGB3重組蛋白
  • 貨號：
    CSB-YP010561HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HMGB3重組蛋白
  • 貨號：
    CSB-EP010561HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HMGB3重組蛋白
  • 貨號：
    CSB-EP010561HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HMGB3重組蛋白
  • 貨號：
    CSB-BP010561HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HMGB3重組蛋白
  • 貨號：
    CSB-MP010561HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HMGB3
  • Uniprot No.：
  • 別名：
    chromosomal protein; Nonhistone; HMG4; High mobility group (nonhistone chromosomal) protein 4; High mobility group box 3 ; High mobility group protein 2a; High mobility group protein 4; High mobility group protein B3; High mobility group protein HMG4 ; HMG 4 ; HMG-2a; HMG-4; HMG2A; HMGB 3 ; Hmgb3; HMGB3_HUMAN; MGC90319; Non histone chromosomal protein; Nonhistone chromosomal protein HMG4
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-200
  • 氨基酸序列
    MAKGDPKKPK GKMSAYAFFV QTCREEHKKK NPEVPVNFAE FSKKCSERWK TMSGKEKSKF DEMAKADKVR YDREMKDYGP AKGGKKKKDP NAPKRPPSGF FLFCSEFRPK IKSTNPGISI GDVAKKLGEM WNNLNDSEKQ PYITKAAKLK EKYEKDVADY KSKGKFDGAK GPAKVARKKV EEEDEEEEEE EEEEEEEEDE
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling.
  • 基因功能參考文獻(xiàn)：
    1. HMGB3 is involved in malignant transformation of hepatocytes and could be a useful biomarker for diagnosis and a potential target for therapy of liver cancer. PMID: 30166860
    2. The study strongly suggests that HMGB3 promotes GBM oncogenesis through the MAPK signalling pathway while miR-200b-3p and miR-200c-3p inhibit its expression. PMID: 30232806
    3. Luciferase reporter assays showed that HMGB3 was directly regulated by miR-205-5p in prostate cancer cells. PMID: 29196733
    4. HMGB3 regulates the genes expression of WNT/beta-catenin pathway PMID: 28678825
    5. Therefore, we infer that HMGB3 is a functional target of miR-27b in modulation of tamoxifen resistance and EMT. PMID: 27363334
    6. these findings demonstrate that HMBG3 may be a potential molecular marker for predicting the prognosis of esophageal squamous cell carcinoma patients PMID: 25755721
    7. our data suggests HMGB3 may serve as an important oncoprotein and indicate that overexpression of HMGB3 in urinary bladder cancer could be used as a potential prognostic marker. PMID: 25647262
    8. High expression of HMGB3 is associated with lymph node metastases in gastric cancer. PMID: 25095979
    9. In this family, microphthalmia, microcephaly, intellectual disability, and short stature are associated with a mutation on the X chromosome in the HMGB3 gene. PMID: 24993872
    10. regulation of HMGB3 by miR-205 reduced both proliferation and invasion of breast cancer cells. PMID: 24098490
    11. Association between co-expression networks involving HMGB3 and differentially-expressed genes in gastric cancer. PMID: 24338397
    12. HMGB3 has a role in gastric cancer disease onset and progression by regulating the cell cycle PMID: 23326140
    13. HMGB3 plays an important role in non-small cell lung cancer progression. PMID: 23609034
    14. Data indicate that myomiR-206 modulates Hmgb3 expression during myogenesis. PMID: 22912879

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Microphthalmia, syndromic, 13 (MCOPS13)
  • 亞細(xì)胞定位：
    Nucleus. Chromosome. Cytoplasm.
  • 蛋白家族：
    HMGB family
  • 組織特異性：
    Expressed predominantly in placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5004

    OMIM: 300193

    KEGG: hsa:3149

    STRING: 9606.ENSP00000359393

    UniGene: Hs.19114



主站蜘蛛池模板： 亚洲区小说区激情区图片区| 国产熟女一区二区三区四区五区 | 欧美成 人版中文字幕| 四虎永久在线精品884aa| 国产无遮挡又黄又爽网站| 欧洲国产伦久久久久久久| 亚洲国产精品18久久久久久 | 又色又爽又高潮免费视频观看| 波多野结衣的av一区二区三区| 黄网站色成年片在线观看| 国产性夜夜春夜夜爽免费下载 | 国产精品人成视频免费999| 韩国精品一区二区三区四区| 黑人尾随强伦姧人妻爽翻天| 伊人久久大香线蕉无码不卡| 国产精品久久久久久久久电影网| 双腿张开被9个男人调教| 蜜桃av亚洲精品一区二区| 成人奭片免费观看| 女人下边被添全过视频的网址| 精品av国产一二三四区| 被窝的午夜无码福利专区| 欧美性大战久久久久xxx| 国产精品免费一区二区三区四区| 亚洲va久久久噜噜噜久久男同| 2018av无码视频在线播放| 人人人妻人人澡人人爽欧美一区| 国产内射老熟女aaaa∵| 成年网站未满十八禁视频天堂| 亚洲精品中国国产嫩草影院美女 | 无码人妻精品一区二区三区久久久| 国产精品久久无码不卡黑寡妇| 三级网站视频在在线播放| 业余 自由 性别 成熟偷窥| 久久久精品久久久久久96| 成在线人免费视频播放| 男人和女人在床的app| 无码av天天av天天爽| 亚洲婷婷五月激情综合app| 中文字幕乱码熟女人妻水蜜桃| 韩国精品一区二区三区四区|