在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HMGB3 Antibody

HMGB3 Antibody

  • 中文名稱：
    HMGB3兔多克隆抗體
  • 貨號：
    CSB-PA121578
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA121578(HMGB3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA121578(HMGB3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane 1-4: 293T cells, hela cells, mouse lung tissue, Mouse brain tissue, Primary antibody: CSB-PA121578(HMGB3 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1.5 minutes
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    HMGB3
  • 別名：
    chromosomal protein; Nonhistone; HMG4 antibody; High mobility group (nonhistone chromosomal) protein 4 antibody; High mobility group box 3 antibody; High mobility group protein 2a antibody; High mobility group protein 4 antibody; High mobility group protein B3 antibody; High mobility group protein HMG4 antibody; HMG 4 antibody; HMG-2a antibody; HMG-4 antibody; HMG2A antibody; HMGB 3 antibody; Hmgb3 antibody; HMGB3_HUMAN antibody; MGC90319 antibody; Non histone chromosomal protein antibody; Nonhistone chromosomal protein HMG4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human HMGB3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:10000
    WB 1:500-1:2000
    IHC 1:20-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling.
  • 基因功能參考文獻(xiàn)：
    1. HMGB3 is involved in malignant transformation of hepatocytes and could be a useful biomarker for diagnosis and a potential target for therapy of liver cancer. PMID: 30166860
    2. The study strongly suggests that HMGB3 promotes GBM oncogenesis through the MAPK signalling pathway while miR-200b-3p and miR-200c-3p inhibit its expression. PMID: 30232806
    3. Luciferase reporter assays showed that HMGB3 was directly regulated by miR-205-5p in prostate cancer cells. PMID: 29196733
    4. HMGB3 regulates the genes expression of WNT/beta-catenin pathway PMID: 28678825
    5. Therefore, we infer that HMGB3 is a functional target of miR-27b in modulation of tamoxifen resistance and EMT. PMID: 27363334
    6. these findings demonstrate that HMBG3 may be a potential molecular marker for predicting the prognosis of esophageal squamous cell carcinoma patients PMID: 25755721
    7. our data suggests HMGB3 may serve as an important oncoprotein and indicate that overexpression of HMGB3 in urinary bladder cancer could be used as a potential prognostic marker. PMID: 25647262
    8. High expression of HMGB3 is associated with lymph node metastases in gastric cancer. PMID: 25095979
    9. In this family, microphthalmia, microcephaly, intellectual disability, and short stature are associated with a mutation on the X chromosome in the HMGB3 gene. PMID: 24993872
    10. regulation of HMGB3 by miR-205 reduced both proliferation and invasion of breast cancer cells. PMID: 24098490
    11. Association between co-expression networks involving HMGB3 and differentially-expressed genes in gastric cancer. PMID: 24338397
    12. HMGB3 has a role in gastric cancer disease onset and progression by regulating the cell cycle PMID: 23326140
    13. HMGB3 plays an important role in non-small cell lung cancer progression. PMID: 23609034
    14. Data indicate that myomiR-206 modulates Hmgb3 expression during myogenesis. PMID: 22912879

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Microphthalmia, syndromic, 13 (MCOPS13)
  • 亞細(xì)胞定位：
    Nucleus. Chromosome. Cytoplasm.
  • 蛋白家族：
    HMGB family
  • 組織特異性：
    Expressed predominantly in placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5004

    OMIM: 300193

    KEGG: hsa:3149

    STRING: 9606.ENSP00000359393

    UniGene: Hs.19114



主站蜘蛛池模板： 特黄特色大片免费播放器图片| 亚洲va久久久噜噜噜久久4399| 日韩精品中文字幕无码专区 | 无码精品国产dvd在线观看9久| 无遮挡裸体免费视频尤物| 丁香五香天堂网| 自慰系列无码专区| 黑人又粗又大又硬a片| 成人网站www污污污网站| 99久久久精品免费观看国产| 7777久久亚洲中文字幕| 亚洲精品无码av中文字幕电影网站 | 无码专区亚洲综合另类| 精品亚洲成av人在线观看| 亚洲中久无码永久在线观看同| 国产av无码专区国产乱码| 亚洲天堂2017无码| 国产杨幂丝袜av在线播放| 亚洲欧美成人精品香蕉网| 日本视频高清一道一区| 插鸡网站在线播放免费观看| 成人国产一区二区三区精品不卡| 久久精品一区二区免费播放| 在线观看特色大片免费网站| 亚洲va久久久噜噜噜久久4399| 亚洲精品卡一卡三卡四卡乱码| 亚洲の无码国产の无码步美| 波多野结衣在线播放| 国内揄拍国内精品人妻浪潮av| 裸体丰满白嫩大尺度尤物| 欧美成人猛片aaaaaaa| 中文字幕人妻少妇引诱隔壁| 九九99久久精品在免费线18| 欧美一区二区三区红桃小说| 精品亚洲一区二区三区四区五区 | 久久久亚洲欧洲日产国码αv| 亚洲欧洲日产无码中文字幕| 精品国产乱码久久久久久口爆| 四房播播开心五月| 岛国av无码免费无禁网站麦芽| 色五月丁香六月欧美综合|