在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HMGB3 Antibody, Biotin conjugated

HMGB3 Antibody, Biotin conjugated

  • 中文名稱：
    HMGB3兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA010561LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) HMGB3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HMGB3
  • 別名：
    chromosomal protein; Nonhistone; HMG4 antibody; High mobility group (nonhistone chromosomal) protein 4 antibody; High mobility group box 3 antibody; High mobility group protein 2a antibody; High mobility group protein 4 antibody; High mobility group protein B3 antibody; High mobility group protein HMG4 antibody; HMG 4 antibody; HMG-2a antibody; HMG-4 antibody; HMG2A antibody; HMGB 3 antibody; Hmgb3 antibody; HMGB3_HUMAN antibody; MGC90319 antibody; Non histone chromosomal protein antibody; Nonhistone chromosomal protein HMG4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human High mobility group protein B3 protein (1-103AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling.
  • 基因功能參考文獻：
    1. HMGB3 is involved in malignant transformation of hepatocytes and could be a useful biomarker for diagnosis and a potential target for therapy of liver cancer. PMID: 30166860
    2. The study strongly suggests that HMGB3 promotes GBM oncogenesis through the MAPK signalling pathway while miR-200b-3p and miR-200c-3p inhibit its expression. PMID: 30232806
    3. Luciferase reporter assays showed that HMGB3 was directly regulated by miR-205-5p in prostate cancer cells. PMID: 29196733
    4. HMGB3 regulates the genes expression of WNT/beta-catenin pathway PMID: 28678825
    5. Therefore, we infer that HMGB3 is a functional target of miR-27b in modulation of tamoxifen resistance and EMT. PMID: 27363334
    6. these findings demonstrate that HMBG3 may be a potential molecular marker for predicting the prognosis of esophageal squamous cell carcinoma patients PMID: 25755721
    7. our data suggests HMGB3 may serve as an important oncoprotein and indicate that overexpression of HMGB3 in urinary bladder cancer could be used as a potential prognostic marker. PMID: 25647262
    8. High expression of HMGB3 is associated with lymph node metastases in gastric cancer. PMID: 25095979
    9. In this family, microphthalmia, microcephaly, intellectual disability, and short stature are associated with a mutation on the X chromosome in the HMGB3 gene. PMID: 24993872
    10. regulation of HMGB3 by miR-205 reduced both proliferation and invasion of breast cancer cells. PMID: 24098490
    11. Association between co-expression networks involving HMGB3 and differentially-expressed genes in gastric cancer. PMID: 24338397
    12. HMGB3 has a role in gastric cancer disease onset and progression by regulating the cell cycle PMID: 23326140
    13. HMGB3 plays an important role in non-small cell lung cancer progression. PMID: 23609034
    14. Data indicate that myomiR-206 modulates Hmgb3 expression during myogenesis. PMID: 22912879

    顯示更多

    收起更多

  • 相關疾病：
    Microphthalmia, syndromic, 13 (MCOPS13)
  • 亞細胞定位：
    Nucleus. Chromosome. Cytoplasm.
  • 蛋白家族：
    HMGB family
  • 組織特異性：
    Expressed predominantly in placenta.
  • 數據庫鏈接：

    HGNC: 5004

    OMIM: 300193

    KEGG: hsa:3149

    STRING: 9606.ENSP00000359393

    UniGene: Hs.19114



主站蜘蛛池模板： 国产一区二区三区精品视频| 欧美人与动牲猛交a欧美精品 | 欧美无遮挡很黄裸交视频| 国产人妻精品一区二区三区不卡 | 欧美老肥妇做爰bbww| 毛片免费全部无码播放| 97一期涩涩97片久久久久久久| 中文字幕人妻熟女av| 蜜桃av亚洲精品一区二区| 蜜臀久久99精品久久久久久小说 | 国产精品一区二区久久不卡| 成人免费一区二区三区| 国产私人尤物无码不卡| 亚洲精品一区二区三区麻豆| 国产成人精品精品日本亚洲| 欧美日韩亚洲中文字幕一区二区三区| 国产精品午夜无码av体验区| 99久久人妻精品免费二区| 国产毛片精品av一区二区| 精品国产不卡在线观看免费| 欧美va久久久噜噜噜久久| 国产人妻精品午夜福利免费| 国产白袜脚足j棉袜在线观看| 久久国产劲暴∨内射新川| 国产模特嫩模私拍视频在线| 人妻熟妇乱又伦精品视频无广告| 中文精品久久久久国产网址| 996久久国产精品线观看| 无码av动漫精品一区二区免费| 欧美孕妇xxxx做受欧美88| 日本一卡二卡四卡无卡国产| 国产精品美女一区二区三区| 国产成人精品2021| 青青草国产久久精品| 精品人妻系列无码人妻不卡| 国产精品未满十八禁止观看| 亚洲精品亚洲人成在线| 亚洲精品无码久久久久yw| 蜜臀av999无码精品国产专区| 强行糟蹋人妻hd中文| 日本三级吃奶头添泬|