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  4. HMGB3 Antibody, Biotin conjugated

HMGB3 Antibody, Biotin conjugated

  • 中文名稱：
    HMGB3兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA010561LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) HMGB3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HMGB3
  • 別名：
    chromosomal protein; Nonhistone; HMG4 antibody; High mobility group (nonhistone chromosomal) protein 4 antibody; High mobility group box 3 antibody; High mobility group protein 2a antibody; High mobility group protein 4 antibody; High mobility group protein B3 antibody; High mobility group protein HMG4 antibody; HMG 4 antibody; HMG-2a antibody; HMG-4 antibody; HMG2A antibody; HMGB 3 antibody; Hmgb3 antibody; HMGB3_HUMAN antibody; MGC90319 antibody; Non histone chromosomal protein antibody; Nonhistone chromosomal protein HMG4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human High mobility group protein B3 protein (1-103AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling.
  • 基因功能參考文獻：
    1. HMGB3 is involved in malignant transformation of hepatocytes and could be a useful biomarker for diagnosis and a potential target for therapy of liver cancer. PMID: 30166860
    2. The study strongly suggests that HMGB3 promotes GBM oncogenesis through the MAPK signalling pathway while miR-200b-3p and miR-200c-3p inhibit its expression. PMID: 30232806
    3. Luciferase reporter assays showed that HMGB3 was directly regulated by miR-205-5p in prostate cancer cells. PMID: 29196733
    4. HMGB3 regulates the genes expression of WNT/beta-catenin pathway PMID: 28678825
    5. Therefore, we infer that HMGB3 is a functional target of miR-27b in modulation of tamoxifen resistance and EMT. PMID: 27363334
    6. these findings demonstrate that HMBG3 may be a potential molecular marker for predicting the prognosis of esophageal squamous cell carcinoma patients PMID: 25755721
    7. our data suggests HMGB3 may serve as an important oncoprotein and indicate that overexpression of HMGB3 in urinary bladder cancer could be used as a potential prognostic marker. PMID: 25647262
    8. High expression of HMGB3 is associated with lymph node metastases in gastric cancer. PMID: 25095979
    9. In this family, microphthalmia, microcephaly, intellectual disability, and short stature are associated with a mutation on the X chromosome in the HMGB3 gene. PMID: 24993872
    10. regulation of HMGB3 by miR-205 reduced both proliferation and invasion of breast cancer cells. PMID: 24098490
    11. Association between co-expression networks involving HMGB3 and differentially-expressed genes in gastric cancer. PMID: 24338397
    12. HMGB3 has a role in gastric cancer disease onset and progression by regulating the cell cycle PMID: 23326140
    13. HMGB3 plays an important role in non-small cell lung cancer progression. PMID: 23609034
    14. Data indicate that myomiR-206 modulates Hmgb3 expression during myogenesis. PMID: 22912879

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  • 相關疾病：
    Microphthalmia, syndromic, 13 (MCOPS13)
  • 亞細胞定位：
    Nucleus. Chromosome. Cytoplasm.
  • 蛋白家族：
    HMGB family
  • 組織特異性：
    Expressed predominantly in placenta.
  • 數據庫鏈接：

    HGNC: 5004

    OMIM: 300193

    KEGG: hsa:3149

    STRING: 9606.ENSP00000359393

    UniGene: Hs.19114



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