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  4. Recombinant Human Heart- and neural crest derivatives-expressed protein 1 (HAND1)

Recombinant Human Heart- and neural crest derivatives-expressed protein 1 (HAND1)

  • 中文名稱：
    人HAND1重組蛋白
  • 貨號：
    CSB-YP010125HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HAND1重組蛋白
  • 貨號：
    CSB-EP010125HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HAND1重組蛋白
  • 貨號：
    CSB-EP010125HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HAND1重組蛋白
  • 貨號：
    CSB-BP010125HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HAND1重組蛋白
  • 貨號：
    CSB-MP010125HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    autonomic nervous system and neural crest derivatives-expressed protein 1; Basic helix loop helix transcription factor HAND1; bHLHa27; Class A basic helix-loop-helix protein 27; eHAND; Extraembryonic tissues; Extraembryonic tissues heart autonomic nervous system and neural crest derivatives expressed protein 1; HAND 1; HAND1; HAND1_HUMAN; Heart and neural crest derivatives expressed 1; Heart and neural crest derivatives expressed protein 1; heart; Heart- and neural crest derivatives-expressed protein 1; Hxt; Thing 1; Thing1 ; Thing1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-215
  • 氨基酸序列
    MNLVGSYAHH HHHHHPHPAH PMLHEPFLFG PASRCHQERP YFQSWLLSPA DAAPDFPAGG PPPAAAAAAT AYGPDARPGQ SPGRLEALGG RLGRRKGSGP KKERRRTESI NSAFAELREC IPNVPADTKL SKIKTLRLAT SYIAYLMDVL AKDAQSGDPE AFKAELKKAD GGRESKRKRE LQQHEGFPPA LGPVEKRIKG RTGWPQQVWA LELNQ
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes.
  • 基因功能參考文獻：
    1. Strikingly, human pluripotent stem cell antibody array showed that Hand1 overexpression resulted in substantial decrease in pluripotency markers (Nanog, Oct3/4, Otx2, Flk1) suggesting that Hand1 expression may be essential to attenuate the EMT and our findings underscore a novel role for Hand1 in medulloblastoma metastasis. PMID: 27297109
    2. association of HAND1 loss-of-function mutation with increased susceptibility to Tetralogy of Fallot PMID: 27942761
    3. These findings expand the phenotypic spectrum linked to HAND1 mutations, suggesting potential implications for the development of novelo prophylactic and therapeutic strategies for DORV. PMID: 28112363
    4. HAND1 loss-of-function mutation is associated with familial dilated cardiomyopathy. PMID: 26581070
    5. Combined expression of NKX2-5, HAND1, and NOTCH1 coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome. PMID: 25050861
    6. These data show that miR-363 negatively regulates the expression of HAND1 PMID: 24906886
    7. Nuclear translocation of Hand-1 acts as a molecular switch to regulate vascular radiosensitivity in medulloblastoma tumors. PMID: 24623737
    8. DNA methylation status of NKX2-5, GATA4 and HAND1 in patients with tetralogy of fallot PMID: 24182332
    9. Increased methylation levels of HAND1 is associated with highly active Helicobacter pylori-related gastritis. PMID: 23292007
    10. This is the first report of mutations in the HAND1 gene in Chinese patients with VSD and provides new insight into the etiology of VSD PMID: 22032825
    11. Hand1 is dispensable for normal tyrosine hydroxylase and dopamine beta-hydroxylase expression in sympathetic neurons, even when Hand2 gene dosage is concurrently reduced by half. PMID: 22323723
    12. Somatic mutations in NKX2-5, GATA4, and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart. PMID: 22043484
    13. Mutations or sequence variations in HAND1 or NKX2-5 genes may play role in etiology or pathogenesis of atrial isomerism. PMID: 21561848
    14. Our study shows no evidence of somatic NKX2-5, GATA4 and HAND1 mutations playing a role in the pathogenesis of Tetralogy of Fallot . Findings suggest that the GATA4 and HAND1 germline mutations are associated with non-syndromic congenital heart disease. PMID: 21519287
    15. Hand1 lineage marks the proepicardial organ and epicardium necessary for epicardial and coronary vessel development, defining the epicardial precursors that are subsequently dependent on Hand2 function. PMID: 21350214
    16. effects of gene mutations on ventricular development PMID: 12858532
    17. MEF2/HAND1 interaction results in synergistic activation of MEF2-dependent promoters, and MEF2 binding sites are sufficient to mediate this synergy PMID: 16043483
    18. In 24 of 31 hypoplastic ventricles, a frameshift mutation was detected in the bHLH domain, which is necessary for DNA binding and combinatorial interactions; thus in hypoplastic human hearts HAND1 function is impaired. PMID: 18276607
    19. HMGA1 proteins bind directly to Hand1 promoter both in vitro and in vivo and inhibit Hand1 promoter activity PMID: 19060921
    20. HAND1 sequence mutations are frequent in human hearts with septation defects. PMID: 19586923

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  • 亞細胞定位：
    Nucleus, nucleoplasm. Nucleus, nucleolus.
  • 組織特異性：
    Heart.
  • 數據庫鏈接：

    HGNC: 4807

    OMIM: 602406

    KEGG: hsa:9421

    STRING: 9606.ENSP00000231121

    UniGene: Hs.152531



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