在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HAND1 Antibody

  • 中文名稱:
    HAND1兔多克隆抗體
  • 貨號:
    CSB-PA080004
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    autonomic nervous system and neural crest derivatives-expressed protein 1 antibody; Basic helix loop helix transcription factor HAND1 antibody; bHLHa27 antibody; Class A basic helix-loop-helix protein 27 antibody; eHAND antibody; Extraembryonic tissues antibody; Extraembryonic tissues heart autonomic nervous system and neural crest derivatives expressed protein 1 antibody; HAND 1 antibody; HAND1 antibody; HAND1_HUMAN antibody; Heart and neural crest derivatives expressed 1 antibody; Heart and neural crest derivatives expressed protein 1 antibody; heart antibody; Heart- and neural crest derivatives-expressed protein 1 antibody; Hxt antibody; Thing 1 antibody; Thing1 antibody; Thing1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human HAND1 around the non-phosphorylation site of S98.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes.
  • 基因功能參考文獻:
    1. Strikingly, human pluripotent stem cell antibody array showed that Hand1 overexpression resulted in substantial decrease in pluripotency markers (Nanog, Oct3/4, Otx2, Flk1) suggesting that Hand1 expression may be essential to attenuate the EMT and our findings underscore a novel role for Hand1 in medulloblastoma metastasis. PMID: 27297109
    2. association of HAND1 loss-of-function mutation with increased susceptibility to Tetralogy of Fallot PMID: 27942761
    3. These findings expand the phenotypic spectrum linked to HAND1 mutations, suggesting potential implications for the development of novelo prophylactic and therapeutic strategies for DORV. PMID: 28112363
    4. HAND1 loss-of-function mutation is associated with familial dilated cardiomyopathy. PMID: 26581070
    5. Combined expression of NKX2-5, HAND1, and NOTCH1 coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome. PMID: 25050861
    6. These data show that miR-363 negatively regulates the expression of HAND1 PMID: 24906886
    7. Nuclear translocation of Hand-1 acts as a molecular switch to regulate vascular radiosensitivity in medulloblastoma tumors. PMID: 24623737
    8. DNA methylation status of NKX2-5, GATA4 and HAND1 in patients with tetralogy of fallot PMID: 24182332
    9. Increased methylation levels of HAND1 is associated with highly active Helicobacter pylori-related gastritis. PMID: 23292007
    10. This is the first report of mutations in the HAND1 gene in Chinese patients with VSD and provides new insight into the etiology of VSD PMID: 22032825
    11. Hand1 is dispensable for normal tyrosine hydroxylase and dopamine beta-hydroxylase expression in sympathetic neurons, even when Hand2 gene dosage is concurrently reduced by half. PMID: 22323723
    12. Somatic mutations in NKX2-5, GATA4, and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart. PMID: 22043484
    13. Mutations or sequence variations in HAND1 or NKX2-5 genes may play role in etiology or pathogenesis of atrial isomerism. PMID: 21561848
    14. Our study shows no evidence of somatic NKX2-5, GATA4 and HAND1 mutations playing a role in the pathogenesis of Tetralogy of Fallot . Findings suggest that the GATA4 and HAND1 germline mutations are associated with non-syndromic congenital heart disease. PMID: 21519287
    15. Hand1 lineage marks the proepicardial organ and epicardium necessary for epicardial and coronary vessel development, defining the epicardial precursors that are subsequently dependent on Hand2 function. PMID: 21350214
    16. effects of gene mutations on ventricular development PMID: 12858532
    17. MEF2/HAND1 interaction results in synergistic activation of MEF2-dependent promoters, and MEF2 binding sites are sufficient to mediate this synergy PMID: 16043483
    18. In 24 of 31 hypoplastic ventricles, a frameshift mutation was detected in the bHLH domain, which is necessary for DNA binding and combinatorial interactions; thus in hypoplastic human hearts HAND1 function is impaired. PMID: 18276607
    19. HMGA1 proteins bind directly to Hand1 promoter both in vitro and in vivo and inhibit Hand1 promoter activity PMID: 19060921
    20. HAND1 sequence mutations are frequent in human hearts with septation defects. PMID: 19586923

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleoplasm. Nucleus, nucleolus.
  • 組織特異性:
    Heart.
  • 數據庫鏈接:

    HGNC: 4807

    OMIM: 602406

    KEGG: hsa:9421

    STRING: 9606.ENSP00000231121

    UniGene: Hs.152531



主站蜘蛛池模板: 中国性欧美videofree精品| 波多野结衣50连登视频| 亚洲国产精品久久亚洲精品| 午夜尤物禁止18点击进入| 一区二区三区国产精华液| 一二三四区无产乱码1000集 | 欧美人与动性xxxxx杂| 久久99国产只有精品| 国产亚洲精选美女久久久久| 国产成人久久av免费| 亚洲一卡二卡三卡四卡| 猫咪av成人永久网站在线观看| 伊人蕉影院久亚洲高清| 中文字字幕在线成人av电影| 国产午夜精品一区二区| 少妇的丰满3中文字幕| 国产交换配乱婬视频偷网站| 国产成人精品免高潮在线观看| 熟女体下毛毛黑森林| 精品蜜臀av在线天堂| 亚洲国产成人久久综合一区77| 国产精品久久久久影院老司| 噜噜噜亚洲色成人网站| 久久本色成人综合网| 国产精品无码av不卡顿| 女人高潮内射99精品| 在线看片免费人成视频福利| 国产午夜福利不卡在线观看| 国产免费牲交视频| 狠狠狠狼鲁亚洲综合网| 亚洲欧美综合国产精品二区| 国产精品成人午夜久久| 日日噜噜噜夜夜爽爽狠狠| 亚洲成av人在线视猫咪| 最新亚洲一卡二卡三卡四卡| 97久久精品人妻人人搡人人玩 | 亚洲热无码av一区二区东京热av| 国产免费二卡3卡四卡| 天天躁日日躁狠狠躁av麻豆| 日本熟日本熟妇在线视频| 国产成人综合一区人人|