在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HAND1 Antibody

  • 中文名稱:
    HAND1兔多克隆抗體
  • 貨號:
    CSB-PA182098
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Immunofluorescence analysis of A549 cells, using HAND1 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) HAND1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human HAND1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes.
  • 基因功能參考文獻(xiàn):
    1. Strikingly, human pluripotent stem cell antibody array showed that Hand1 overexpression resulted in substantial decrease in pluripotency markers (Nanog, Oct3/4, Otx2, Flk1) suggesting that Hand1 expression may be essential to attenuate the EMT and our findings underscore a novel role for Hand1 in medulloblastoma metastasis. PMID: 27297109
    2. association of HAND1 loss-of-function mutation with increased susceptibility to Tetralogy of Fallot PMID: 27942761
    3. These findings expand the phenotypic spectrum linked to HAND1 mutations, suggesting potential implications for the development of novelo prophylactic and therapeutic strategies for DORV. PMID: 28112363
    4. HAND1 loss-of-function mutation is associated with familial dilated cardiomyopathy. PMID: 26581070
    5. Combined expression of NKX2-5, HAND1, and NOTCH1 coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome. PMID: 25050861
    6. These data show that miR-363 negatively regulates the expression of HAND1 PMID: 24906886
    7. Nuclear translocation of Hand-1 acts as a molecular switch to regulate vascular radiosensitivity in medulloblastoma tumors. PMID: 24623737
    8. DNA methylation status of NKX2-5, GATA4 and HAND1 in patients with tetralogy of fallot PMID: 24182332
    9. Increased methylation levels of HAND1 is associated with highly active Helicobacter pylori-related gastritis. PMID: 23292007
    10. This is the first report of mutations in the HAND1 gene in Chinese patients with VSD and provides new insight into the etiology of VSD PMID: 22032825
    11. Hand1 is dispensable for normal tyrosine hydroxylase and dopamine beta-hydroxylase expression in sympathetic neurons, even when Hand2 gene dosage is concurrently reduced by half. PMID: 22323723
    12. Somatic mutations in NKX2-5, GATA4, and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart. PMID: 22043484
    13. Mutations or sequence variations in HAND1 or NKX2-5 genes may play role in etiology or pathogenesis of atrial isomerism. PMID: 21561848
    14. Our study shows no evidence of somatic NKX2-5, GATA4 and HAND1 mutations playing a role in the pathogenesis of Tetralogy of Fallot . Findings suggest that the GATA4 and HAND1 germline mutations are associated with non-syndromic congenital heart disease. PMID: 21519287
    15. Hand1 lineage marks the proepicardial organ and epicardium necessary for epicardial and coronary vessel development, defining the epicardial precursors that are subsequently dependent on Hand2 function. PMID: 21350214
    16. effects of gene mutations on ventricular development PMID: 12858532
    17. MEF2/HAND1 interaction results in synergistic activation of MEF2-dependent promoters, and MEF2 binding sites are sufficient to mediate this synergy PMID: 16043483
    18. In 24 of 31 hypoplastic ventricles, a frameshift mutation was detected in the bHLH domain, which is necessary for DNA binding and combinatorial interactions; thus in hypoplastic human hearts HAND1 function is impaired. PMID: 18276607
    19. HMGA1 proteins bind directly to Hand1 promoter both in vitro and in vivo and inhibit Hand1 promoter activity PMID: 19060921
    20. HAND1 sequence mutations are frequent in human hearts with septation defects. PMID: 19586923

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus, nucleoplasm. Nucleus, nucleolus.
  • 組織特異性:
    Heart.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4807

    OMIM: 602406

    KEGG: hsa:9421

    STRING: 9606.ENSP00000231121

    UniGene: Hs.152531



主站蜘蛛池模板: 国产精品久久久久久不卡盗摄 | 丰满肥臀大屁股熟妇激情视频| 蜜桃传媒av免费观看麻豆| 国产特级毛片aaaaaa| 免费欧洲美女牲交视频 | 久久久国产乱子伦精品| 无码h黄肉动漫在线观看| 久久欧美国产伦子伦精品| 精品国产第一国产综合精品| 欧洲免费一区二区三区视频| 性色高清xxxxx厕所偷窥| 亚洲s码欧洲m码国产av| 狂野欧美性猛交xxxx| 男人边吃奶边做好爽免费视频| 亚洲国产欧美在线看片一国产 | 偷窥 亚洲 另类 图片 熟女| 成人视频在线观看| 中文字幕人乱码中文字幕| 又色又爽又黄的视频日本| 大屁股国产白浆一二区| 中文字幕人妻熟女av| 小雪尝禁果又粗又大的视频| 亚洲欧美国产精品久久| 精品免费国产一区二区三区四区介绍 | 欧美人与性动交g欧美精器| 成人午夜无码精品免费看| 日韩国产高清一区二区| 国产一区二区三区成人欧美日韩在线观看 | 美女av一区二区三区| 成人做受黄大片| 97在线观看播放| 免费观看四虎精品国产地址| 亚洲国产成人久久一区二区三区| 欧美亚洲综合在线一区| 制服丝袜另类专区制服| 免费看小12萝裸体视频国产| 亚洲国产精品久久久久爰| 69精品丰满人妻无码视频a片| 2020国产精品午夜福利在线观看 | 国产精品丝袜一区二区三区| 欧美人与动另类xxxx|