在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Golgi resident protein GCP60 (ACBD3)

Recombinant Human Golgi resident protein GCP60 (ACBD3)

  • 中文名稱：
    Recombinant Human Golgi resident protein GCP60(ACBD3)
  • 貨號(hào)：
    CSB-YP863972HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Golgi resident protein GCP60(ACBD3)
  • 貨號(hào)：
    CSB-EP863972HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Golgi resident protein GCP60(ACBD3)
  • 貨號(hào)：
    CSB-EP863972HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Golgi resident protein GCP60(ACBD3)
  • 貨號(hào)：
    CSB-BP863972HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Golgi resident protein GCP60(ACBD3)
  • 貨號(hào)：
    CSB-MP863972HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ACBD3
  • Uniprot No.：
  • 別名：
    ACBD 3; ACBD3; Acyl CoA binding domain containing protein 3; Acyl Coenzyme A binding domain containing 3; Acyl-CoA-binding domain-containing protein 3; GCP 60; GCP60; GCP60_HUMAN; GOCAP 1; GOCAP1; Golgi complex associated protein 1 60kDa; Golgi complex associated protein 1; Golgi complex-associated protein 1; Golgi phosphoprotein 1; Golgi resident protein GCP60; GOLPH 1; GOLPH1; PAP 7; PAP7; PBR and PKA associated protein 7; PBR associated protein; PBR- and PKA-associated protein 7; Peripheral benzodiazepine receptor associated protein PAP7; Peripheral benzodiazepine receptor-associated protein PAP7; Peripherial benzodiazepine receptor associated protein; PKA (RIalpha) associated protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    2-528
  • 氨基酸序列
    AAVLNAERL EVSVDGLTLS PDPEERPGAE GAPLLPPPLP PPSPPGSGRG PGASGEQPEP GEAAAGGAAE EARRLEQRWG FGLEELYGLA LRFFKEKDGK AFHPTYEEKL KLVALHKQVL MGPYNPDTCP EVGFFDVLGN DRRREWAALG NMSKEDAMVE FVKLLNRCCH LFSTYVASHK IEKEEQEKKR KEEEERRRRE EEERERLQKE EEKRRREEEE RLRREEEERR RIEEERLRLE QQKQQIMAAL NSQTAVQFQQ YAAQQYPGNY EQQQILIRQL QEQHYQQYMQ QLYQVQLAQQ QAALQKQQEV VVAGSSLPTS SKVNATVPSN MMSVNGQAKT HTDSSEKELE PEAAEEALEN GPKESLPVIA APSMWTRPQI KDFKEKIQQD ADSVITVGRG EVVTVRVPTH EEGSYLFWEF ATDNYDIGFG VYFEWTDSPN TAVSVHVSES SDDDEEEEEN IGCEEKAKKN ANKPLLDEIV PVYRRDCHEE VYAGSHQYPG RGVYLLKFDN SYSLWRSKSV YYRVYYTR
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase.; (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites.
  • 基因功能參考文獻(xiàn)：
    1. These results reveal a mechanism of EV71 replication that involves host ACBD3 for viral replication. PMID: 28303920
    2. that ACBD3 may represent candidate therapeutic targets to enable the elimination of breast cancer stem cells PMID: 29307786
    3. ACBD3 was found as a gene expression variability marker in 8-cell human embryos. PMID: 26288249
    4. the component proteins of the machinery, OSBP, VAP, SAC1, and PITPNB, are all essential host factors for AiV replication. Importantly, the machinery is directly recruited to the RNA replication sites through previously unknown interactions of VAP/OSBP/SAC1 with the AiV proteins and with ACBD3. PMID: 29367253
    5. Results show that Aichi virus 3A protein activates the lipid kinase activity of PI4KIIIb,which activation is sensitized by the protein ACBD3. The interfaces between PI4KIIIbeta-ACBD3 and ACBD3-3A were mapped with hydrogen-deuterium exchange mass spectrometry. PMID: 27989622
    6. Kobuviral non-structural 3A proteins act as molecular harnesses to hijack the host ACBD3 protein. PMID: 28065508
    7. The authors propose a model in which interaction between Salmonella enterica serovar Typhimurium SseF and SseG enables both proteins to bind ACBD3, thereby anchoring Salmonella-containing vacuoles at the Golgi network and facilitating bacterial replication. PMID: 27406559
    8. these findings suggest that ACBD3 has prominent impacts on cellular NAD(+) metabolism via regulating PARP1 activation-dependent auto-modification and thus cell metabolism and function. PMID: 25940138
    9. Authors found that NS5A and PI4KB competed for association of acyl-coenzyme A binding domain containing protein 3 (ACBD3), which inhibited hepatitis C virus replication. PMID: 24792752
    10. Host ACBD3, PI4KIIIBETA and Aichi virus proteins complexes enhances phosphatidylinositol 4-phosphate synthesis and is critical for viral replication. PMID: 24672044
    11. ACBD3 mediates mHtt cytotoxicity via a Rhes/mHtt/ACBD3 complex. PMID: 24012756
    12. Authors found that the Golgi protein acyl-coenzyme A binding domain-containing 3 (ACBD3), interacts with the 3A proteins of poliovaccine Sabintpe 2 and coxsackievirus A17 at viral RNA replication sites. PMID: 23926333
    13. ACBD3 plays an essential role in maintaining lipid homeostasis via regulating SREBP1's processing pathway and thus impacting cellular lipogenesis. PMID: 23166793
    14. identified ACBD3 as an interacting partner of PPM1L, and showed that this association, which recruits PPM1L to ER-Golgi membrane contact sites, is mediated by a GOLD (Golgi dynamics) domain in ACBD3 PMID: 22796112
    15. The data were consistent with PAP7 interacting with DMT1 and regulating DMT1 expression in K562 cells by modulating expression of DMT1 protein. PMID: 22383495
    16. The 3A protein of picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIbeta. PMID: 22258260
    17. results indicate that a viral protein/ACBD3/PI4KB complex is formed to synthesize PI4P at the AiV RNA replication sites and plays an essential role in viral RNA replication PMID: 22124328
    18. Molecular cloning, chromosomal localization and expression pattern of PAP7. PMID: 12692076
    19. GCP60 interacts preferentially with one of the golgin-160 caspase cleavage fragments (residues 140-311). This strong interaction prevented the golgin-160 fragment from accumulating in the nucleus when this fragment and GCP60 were overexpressed. PMID: 16870622
    20. nuclear translocation of golgin-160-(140-311) is a highly coordinated event regulated not only by cleavage of the golgin-160 head but also by the oxidation state of GCP60 PMID: 17711851

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion.
  • 組織特異性：
    Ubiquitous, with highest expression in testis and ovary.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15453

    OMIM: 606809

    KEGG: hsa:64746

    STRING: 9606.ENSP00000355777

    UniGene: Hs.520207



主站蜘蛛池模板： 国产精品毛片va一区二区三区| 亚洲国产a∨无码中文777| 色一情一乱一伦麻豆| 国产精品一卡二卡三卡四卡| 波多野结衣一区二区三区高清av| 青青青草国产线观| 国产午夜福利在线播放87| 国产成年无码久久久免费| 亚洲中文字幕无码不卡电影| 精品一区二区不卡无码av| 在线 | 麻豆国产传媒61国产免费| 久久天天躁夜夜躁狠狠85台湾| 熟妇的奶头又大又长奶水视频| 热99re久久精品这里都是精品| 精品久久久久久国产| 午夜福利理论片高清在线| 男人扒开女人双腿猛进免费视频| 免费无码av一区二区三区| 玩弄少妇人妻| 精品国产一区二区三区四区在线看| 欧美特级婬片毛多的少妇| 少妇又色又紧又爽又刺激视频 | 久艹视频免费看| 国产成人精品a∨一区二区| 初尝黑人巨砲波多野结衣| 色av综合av综合无码网站| 亚洲第一最快av网站| 巨爆乳中文字幕巨爆区巨爆乳无码 | 久久九九久精品国产免费直播| 亚洲熟妇色自偷自拍另类| 国产精品狼人久久久久影院| 黄网站免费永久在线观看下载| 亚洲精品无码av中文字幕| 中文字幕色av一区二区三区| 正在播放重口老熟女露脸| 无码av免费一区二区三区四区| 男女啪啪激烈高潮喷出gif免费| 沈阳45老熟女高潮喷水亮点| 内射干少妇亚洲69xxx| 人人妻人人爽人人做夜欢视频九色 | 中文字幕人妻被公上司喝醉在线 |