在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Glutamate receptor 3 (GRIA3), partial

Recombinant Human Glutamate receptor 3 (GRIA3), partial

In Stock
  • 中文名稱：
    人GRIA3重組蛋白
  • 貨號：
    CSB-EP009900HU
  • 規格：
    ￥1344
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    AMPA 3; AMPA selective glutamate receptor 3; AMPA-selective glutamate receptor 3; dJ1171F9.1; GluA3; GLUK3; GluR 3; GLUR C; GLUR K3; GluR-3; GluR-C; GluR-K3; GLUR3; GLURC; Glutamate ionotropic receptor AMPA type subunit 3; Glutamate receptor 3; Glutamate receptor C; Glutamate receptor ionotrophic AMPA 3; Glutamate receptor ionotropic; Glutamate receptor subunit 3; Glutamate receptor; ionotropic; AMPA 3; GRIA 3; Gria3; GRIA3_HUMAN; Ionotrophic Glutamate Receptor; MRX94
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    28.0kDa
  • 表達區域：
    151-250aa
  • 氨基酸序列
    SLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
  • 基因功能參考文獻：
    1. Results suggest a role for GluA3 channel activity in the regulation of sleep behavior in both mice and humans. PMID: 29016847
    2. miR-330-3p up-regulated the total DNA methylation in non-small cell lung cancer cells, and co-IP-demonstrated GRIA3 was directly related with DNMT1 and DNMT3A. GRIA3 is a direct target of miR-330-3p. PMID: 28629431
    3. This study showed the lower GluA3 mRNA levels in pregnant women. PMID: 28284346
    4. the impaired surface expression of homomeric GluA3 receptors is caused by nonproductive assembly and aggregation to which LBD residues Tyr-454 and Arg-461 strongly contribute. PMID: 26912664
    5. This study demonstrated that the GRIA3 protein was altered in auditory cortex patient with schizophreia. PMID: 25433904
    6. An association was observed in migraine patients with the GRIA3 single nucleotide polymorphism rs3761555. PMID: 23772601
    7. The ionotrophic glutamate receptors AMPA3 and AMPA3 were decreased in hippocampus in patient with multiple sclerosis. PMID: 23595422
    8. The rs557762 and the TT haplotype in the 11th haplotype block of the GRIA3 gene were associated with feelings of guilt in females. PMID: 22429480
    9. the promoter methylation of the GMR2 and GMR5 genes greatly decreased the risk of schizophrenia, and the expression level of the GRM2, GRM5, and GRIA3 genes increased significantly in patients in comparison to healthy controls. PMID: 23149219
    10. SNP rs687577 associated with sleep duration and depression risk in Finnish women PMID: 21966062
    11. GRIA3 plays a role as a mediator of tumor progression in pancreatic cancer downstream CUX1. PMID: 20689760
    12. Two variants in the regulative regions of GRIA1 (rs2195450) and GRIA3 (rs3761555) genes resulted strongly associated with MA (P = 0.00002 and P = 0.0001, respectively), but not associated with MO PMID: 20579352
    13. AQP3 gene isn't the responsible gene for this pedigree with auditory neuropathy. PMID: 20564826
    14. This study demonistrated that the level of metabotropic glutamate receptor 2/3 is elevated in the prefrontal cortex in patient of major depression disorder. PMID: 19945495
    15. The mGlu3 receptor is located on a number of GABAergic interneurons throughout the brain. mGlu3 receptor is one of two primary mGlu receptors that modulate the function of glia. The mGlu3 receptor is present as a postsynaptic receptor as well. PMID: 19933774
    16. T lymphocytes from normal individuals, an alloprimed human T cell clone, and human T leukemia (Jurkat) cells all express high levels of GluR3, identical in sequence with brain GluR3. PMID: 12682273
    17. cleavage and release to the extracellular milieu of the GluR3B peptide may in principle increase its antigenicity PMID: 17202328
    18. study provides the genetic and functional evidence that mutant iGluR3 with altered kinetic properties is associated with moderate cognitive impairment in humans PMID: 17989220
    19. results support the involvement of genes GRIA3 and GRIK2 in antidepressant treatment-emergent suicidal ideation PMID: 18593792
    20. Aberrant GRIA3 transcripts with multi-exon duplications in a family with X-linked mental retardation are reported. PMID: 19449417

    顯示更多

    收起更多

  • 相關疾病：
    Mental retardation, X-linked 94 (MRX94)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA3 subfamily
  • 數據庫鏈接：

    HGNC: 4573

    OMIM: 300699

    KEGG: hsa:2892

    STRING: 9606.ENSP00000264357

    UniGene: Hs.377070



主站蜘蛛池模板： 蜜桃成人无码区免费视频网站| 色偷偷色噜噜狠狠网站久久 | 国产aⅴ爽av久久久久久| 97色伦午夜国产亚洲精品| 丰满大肥婆肥奶大屁股| 最爽free性欧美人妖| 特黄特级毛片免费视频| 无码人妻巨屁股系列| 亚洲精品久久久久一区二区| 亚洲精品一区| 亚洲中文字幕乱码电影| 亚洲日韩va在线视频| 欧美精品一区二区三区在线| 337p粉嫩大胆噜噜噜| 国产无夜激无码av毛片| 国产午夜鲁丝片av无码免费| 美女视频黄频大全免费| 国产 麻豆 日韩 欧美 久久 | 久久综合色鬼综合色| 精品系列无码一区二区三区| 黑人巨大av无码专区| 欧美性猛交xxxx免费看蜜桃| 欧美日韩国产一区二区三区不卡| 国产精品夜夜春夜夜爽久久| 国产高清不卡一区二区| 成人毛片无码一区二区三区| 午夜亚洲www湿好大| 护士奶头又大又软又好摸| 大陆国语对白国产av片| 人妻系列无码专区久久五月天| 亚洲春色av无码专区在线播放| 久久精品女人天堂av免费观看| 国产suv精品一区二区五| 久久综合97丁香色香蕉| 亚洲无碼网站观看| 色135综合网| 2021精品国夜夜天天拍拍| 女上男下啪啪激烈高潮无遮盖 | 精品国产a∨无码一区二区三区| 免费国产在线一区二区| 蜜臀av 国内精品久久久|