在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GRIA3 Antibody

GRIA3 Antibody

  • 中文名稱：
    GRIA3兔多克隆抗體
  • 貨號：
    CSB-PA100222
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA100222(GRIA3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA100222(GRIA3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AMPA 3 antibody; AMPA selective glutamate receptor 3 antibody; AMPA-selective glutamate receptor 3 antibody; dJ1171F9.1 antibody; GluA3 antibody; GLUK3 antibody; GluR 3 antibody; GLUR C antibody; GLUR K3 antibody; GluR-3 antibody; GluR-C antibody; GluR-K3 antibody; GLUR3 antibody; GLURC antibody; Glutamate ionotropic receptor AMPA type subunit 3 antibody; Glutamate receptor 3 antibody; Glutamate receptor C antibody; Glutamate receptor ionotrophic AMPA 3 antibody; Glutamate receptor ionotropic antibody; Glutamate receptor subunit 3 antibody; Glutamate receptor; ionotropic; AMPA 3 antibody; GRIA 3 antibody; Gria3 antibody; GRIA3_HUMAN antibody; Ionotrophic Glutamate Receptor antibody; MRX94 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human GRIA3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
  • 基因功能參考文獻：
    1. Results suggest a role for GluA3 channel activity in the regulation of sleep behavior in both mice and humans. PMID: 29016847
    2. miR-330-3p up-regulated the total DNA methylation in non-small cell lung cancer cells, and co-IP-demonstrated GRIA3 was directly related with DNMT1 and DNMT3A. GRIA3 is a direct target of miR-330-3p. PMID: 28629431
    3. This study showed the lower GluA3 mRNA levels in pregnant women. PMID: 28284346
    4. the impaired surface expression of homomeric GluA3 receptors is caused by nonproductive assembly and aggregation to which LBD residues Tyr-454 and Arg-461 strongly contribute. PMID: 26912664
    5. This study demonstrated that the GRIA3 protein was altered in auditory cortex patient with schizophreia. PMID: 25433904
    6. An association was observed in migraine patients with the GRIA3 single nucleotide polymorphism rs3761555. PMID: 23772601
    7. The ionotrophic glutamate receptors AMPA3 and AMPA3 were decreased in hippocampus in patient with multiple sclerosis. PMID: 23595422
    8. The rs557762 and the TT haplotype in the 11th haplotype block of the GRIA3 gene were associated with feelings of guilt in females. PMID: 22429480
    9. the promoter methylation of the GMR2 and GMR5 genes greatly decreased the risk of schizophrenia, and the expression level of the GRM2, GRM5, and GRIA3 genes increased significantly in patients in comparison to healthy controls. PMID: 23149219
    10. SNP rs687577 associated with sleep duration and depression risk in Finnish women PMID: 21966062
    11. GRIA3 plays a role as a mediator of tumor progression in pancreatic cancer downstream CUX1. PMID: 20689760
    12. Two variants in the regulative regions of GRIA1 (rs2195450) and GRIA3 (rs3761555) genes resulted strongly associated with MA (P = 0.00002 and P = 0.0001, respectively), but not associated with MO PMID: 20579352
    13. AQP3 gene isn't the responsible gene for this pedigree with auditory neuropathy. PMID: 20564826
    14. This study demonistrated that the level of metabotropic glutamate receptor 2/3 is elevated in the prefrontal cortex in patient of major depression disorder. PMID: 19945495
    15. The mGlu3 receptor is located on a number of GABAergic interneurons throughout the brain. mGlu3 receptor is one of two primary mGlu receptors that modulate the function of glia. The mGlu3 receptor is present as a postsynaptic receptor as well. PMID: 19933774
    16. T lymphocytes from normal individuals, an alloprimed human T cell clone, and human T leukemia (Jurkat) cells all express high levels of GluR3, identical in sequence with brain GluR3. PMID: 12682273
    17. cleavage and release to the extracellular milieu of the GluR3B peptide may in principle increase its antigenicity PMID: 17202328
    18. study provides the genetic and functional evidence that mutant iGluR3 with altered kinetic properties is associated with moderate cognitive impairment in humans PMID: 17989220
    19. results support the involvement of genes GRIA3 and GRIK2 in antidepressant treatment-emergent suicidal ideation PMID: 18593792
    20. Aberrant GRIA3 transcripts with multi-exon duplications in a family with X-linked mental retardation are reported. PMID: 19449417

    顯示更多

    收起更多

  • 相關疾病：
    Mental retardation, X-linked 94 (MRX94)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA3 subfamily
  • 數據庫鏈接：

    HGNC: 4573

    OMIM: 300699

    KEGG: hsa:2892

    STRING: 9606.ENSP00000264357

    UniGene: Hs.377070



主站蜘蛛池模板： 9420免费高清在线观看视频| 国产亚洲人成网站观看| 国产精品午夜成人免费观看 | 国产在线观看免费人成视频| 再深点灬舒服灬太大了在线视频| 国精产品一区一区三区免费视频| 久久精品国产一区二区三区不卡| 成在人线av无码免费| 少妇愉情理伦片丰满丰满午夜| 九九热线精品视频16| 97se狼狼狼狼狼亚洲网| 亚洲高清国产拍精品闺蜜合租| 美丽的熟妇中文字幕| 色噜噜狠狠一区二区三区果冻| 东京热人妻无码一区二区av| 亚洲成av大片大片在线播放| 亚洲欧美综合精品二区| 亚洲高清毛片一区二区| 性猛交ⅹxxx富婆视频| 国产女人高潮视频在线观看| 最新亚洲精品国偷自产在线| 国产精品久久久久久久伊一| 亚洲一区二区三区av天堂| 精品黑人一区二区三区久久| 国产日产欧产精品精品蜜芽 | 天天狠天天天天透在线| 中文字幕v亚洲日本在线| 粗大的内捧猛烈进出看视频| 少妇被躁爽到高潮无码文| 性生交大片免费看| 欧美日韩一区二区三区自拍| 午夜伦4480yy私人影院久久| 日本xxxx片免费观看| 国产熟妇另类久久久久| 97国产精东麻豆人妻电影| 午夜好爽好舒服免费视频| 久久精品国产亚洲不av麻豆| 欧美午夜一区二区福利视频| 国产一区二区三区| 久久亚洲精品无码gv| 免费观看又色又爽又湿的软件 |