在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Glucose-dependent insulinotropic receptor (GPR119), partial

Recombinant Human Glucose-dependent insulinotropic receptor (GPR119), partial

  • 中文名稱：
    人GPR119重組蛋白
  • 貨號(hào)：
    CSB-YP840575HU1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GPR119重組蛋白
  • 貨號(hào)：
    CSB-EP840575HU1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GPR119重組蛋白
  • 貨號(hào)：
    CSB-EP840575HU1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GPR119重組蛋白
  • 貨號(hào)：
    CSB-BP840575HU1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GPR119重組蛋白
  • 貨號(hào)：
    CSB-MP840575HU1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    GPR119; Glucose-dependent insulinotropic receptor; G-protein coupled receptor 119
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
  • 基因功能參考文獻(xiàn)：
    1. GPR119 is the oleoyl-lysophosphatidylinositol receptor that is required for GLP-1 secretion in enteroendocrine cells. PMID: 29883799
    2. Angelica dahurica extract-treated cells showed significant increases in GPR119 activation, intracellular cAMP levels, GLP-1 levels and glucose-stimulated insulin secretion as compared with controls PMID: 27391814
    3. Describe novel small-molecule GPR119 agonists with high receptor selectivity and capacity to induce glucose-stimulated insulin secretion. PMID: 24681896
    4. The GPR119 agonist, HD0471042 increased intracellular cAMP levels in stably human GPR119 expressing CHO cells. PMID: 23897163
    5. Oxidized-LDL significantly induces lincRNA-DYNLRB2-2 expression, which promotes ABCA1-mediated cholesterol efflux and inhibits inflammation through GPR119 in THP-1 cells. PMID: 24493833
    6. Replacement of the three methyl groups in 1 with metabolically stable moieties led to the identification of compound 34, a potent and efficacious GPR119 agonist with improved pharmacokinetic (PK) properties. PMID: 23648181
    7. transfection of GLUTag cells with recombinant human GPR119 results in a constitutive and apparently ligand-independent increase of proglucagon gene promoter activity and proglucagon mRNA content. PMID: 23798572
    8. Results provide evidence of an islet-gastrointestinal distribution of GPR119, its expression in pancreatic beta and alpha cells, and its possible involvement in islet function. PMID: 22883930
    9. Data suggest that GPR119 activation/up-regulation in skeletal muscle impairs fatty acid and glucose oxidation; diet-induced obesity appears to up-regulate skeletal muscle GPR119. PMID: 23069642
    10. Data show that Phe-V:13 can serve as an aromatic lock for the proposed active conformation of the Trp-VI:13 rotameric switch, being involved in the global movement of TM-V and TM-VI in 7TM receptor activation. PMID: 19920139
    11. findings show that N-oleoyldopamine (OLDA)& structurally related hydroxybenzyl amides are robust activators of GPR119; studies indicate that multiple, distinct classes of lipid amides, acting via GPR119, may be important modulators of glucose homeostasis PMID: 19901198
    12. GPR119 therefore represents a novel and attractive potential target for the therapy of obesity and related metabolic disorders. PMID: 16517404

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Predominantly expressed in the pancreas, especially in the islets.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19060

    OMIM: 300513

    KEGG: hsa:139760

    STRING: 9606.ENSP00000276218

    UniGene: Hs.496762



主站蜘蛛池模板： 国产aⅴ精品一区二区三区| 亚欧欧美人成视频在线| 狼友av永久网站免费观看孕交| 久久99精品久久久久久久不卡 | 狠狠躁天天躁中文字幕无码| 成人性能视频在线| 国产麻豆乱子伦午夜视频观看| 国产精品爽爽久久久久久无码| 图片区小说区av区| www亚洲精品少妇裸乳一区二区 | 一本久久综合亚洲鲁鲁五月天| 国产超碰人人模人人爽人人喊| 亚洲精品国产av成拍色拍婷婷| 久久国产福利国产秒拍飘飘网| 国产黄大片在线观看| 国产熟妇勾子乱视频| 免费乱理伦片在线观看| 国产成人啪精品午夜网站a片免费| 成熟人妻av无码专区| 国模小婕私拍鲜嫩玉门| 久久久一本精品99久久精品66直播| 男女啪啪永久免费网站| 麻豆精产国品| 久久精品99av高久久精品| 午夜精品影视国产一区在线麻豆 | 在线亚洲精品国产一区麻豆| 丰满又黄又爽少妇毛片| 131美女爱做视频免费| 天堂а√在线最新版中文在线| 国产成人综合久久久久久| 国产成人美女裸体片免费看| 无码日韩精品一区二区免费暖暖 | 亚洲a∨无码一区二区| 色一情一乱一伦一区二区三区小说 | 欧美性插b在线视频网站| 欧美不卡无线在线一二三区观 | 好吊妞人成视频在线观看27du| 么公的好大好硬好深好爽视频| 亚洲综合另类小说色区| 蜜臀av 国内精品久久久| 欧美日韩午夜群交多人轮换|