Recombinant Human Gamma-glutamylcyclotransferase (GGCT)

中文名稱(chēng)：

人GGCT重組蛋白
貨號(hào)：

CSB-YP009387HU
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

人GGCT重組蛋白
貨號(hào)：

CSB-EP009387HU-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

人GGCT重組蛋白
貨號(hào)：

CSB-BP009387HU
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

人GGCT重組蛋白
貨號(hào)：

CSB-MP009387HU
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

GGCT
Uniprot No.：

O75223
別名：

C7orf24; CRF21; Cytochrome c-releasing factor 21; Gamma glutamyl cyclotransferase; Gamma-glutamylcyclotransferase; GCTG; GGC; Ggct; GGCT_HUMAN
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Full length protein
表達(dá)區(qū)域：

1-188
氨基酸序列

MANSGCKDVT GPDEESFLYF AYGSNLLTER IHLRNPSAAF FCVARLQDFK LDFGNSQGKT SQTWHGGIAT IFQSPGDEVW GVVWKMNKSN LNSLDEQEGV KSGMYVVIEV KVATQEGKEI TCRSYLMTNY ESAPPSPQYK KIICMGAKEN GLPLEYQEKL KAIEPNDYTG KVSEEIEDII KKGETQTL
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.
基因功能參考文獻(xiàn)：
1. GGCT is highly upregulated in HGSC tissues and associated with FIGO stage, lymph node metastasis and ascitic fluid volume. High expression of GGCT is associated with poor survival in HGSC patients. PMID: 29429592
2. Taken together, the results indicate that PHB2 plays a central role in p21 upregulation following GGCT knockdown and as such may promote deregulated proliferation of cancer cells by suppressing p21. PMID: 29307834
3. GGCT plays a critical role in glioma cell proliferation and may be a potential cancer therapeutic target. PMID: 26828272
4. GGCT is promising as a diagnostic marker and a therapeutic target for various cancers. This review summarizes these interesting findings. PMID: 26339607
5. G6PD, GGCT, IDH1, isocitrate dehydrogenase 2 (NADP+,mitochondrial) (IDH2) and glutathione S-transferase pi 1(GSTP1), five of the critical components of GSH pathway, contribute to chemoresistance. PMID: 25818003
6. GGCT plays a critical role in lung cancer cell proliferation. PMID: 25941902
7. Transcriptional silencing of the C7orf24 gene in the non-malignant cells is elicited through heterochromatin formation in its promoter region. PMID: 23853312
8. increased expression of GGCT was a common event among invasive esophageal squamous cell carcinoma tissues regardless of the depth of invasion. Lymph node metastasis and tumor differentiation correlated with GGCT expression PMID: 24342434
9. C7orf24 has been recognized as a potent marker for bladder and breast cancers. Studies on the role of gamma-glutamylcyclotransferace may aid in the control of malignant transformation of these cancers. PMID: 23513927
10. GGCT may be a biomarker of tumors in a limited range of organs. PMID: 22205682
11. C7orf24 overexpression defines a subgroup of breast tumors with poor clinical outcome. PMID: 20527979
12. CRF21 might play an important role in the induction of apoptosis by GGO in leukemia U937 cells. PMID: 16765912
13. presence of extra electron density/ligands and conservation at the sequence and structure levels, it is likely that the cavity has a crucial role in the function of LOC79017 and its structural neighbors possibly as an active site or ligand-binding site PMID: 17932939
14. The GGCT gene is located on chromosome 7p14-15 and consists of four exons that span 8 kb, the primary sequence is 188 amino acids in length and is unlike any protein of known function PMID: 18515354
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蛋白家族：

Gamma-glutamylcyclotransferase family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 21705

OMIM: 137170

KEGG: hsa:79017

STRING: 9606.ENSP00000275428

UniGene: Hs.530024