在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)

In Stock
  • 中文名稱:
    Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)
  • 貨號:
    CSB-EP861986HUc7
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    Early estrogen-regulated protein;GABAA;Glandular epithelial cell protein 1;GEC-1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    14.9 kDa
  • 表達區域:
    1-117aa
  • 氨基酸序列
    MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYGK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.
  • 基因功能參考文獻:
    1. these results indicate that miR-195 regulates cell proliferation, migration, angiogenesis and autophagy of hEPCs by targeting GABARAPL1 PMID: 27623937
    2. Our data demonstrated that a specific decrease of GABARAPL1 expression in breast cancers was associated with both DNA methylation and histone deacetylation and that CREB-1 recruitment on GABARAPL1 PMID: 26474850
    3. Androgen deprivation downregulates Gabarapl1 in an AR dependent manner, resulting in the increase of autophagy flux PMID: 26050226
    4. GABARAPL1 plays an important role in cell proliferation, invasion, and autophagic flux, as well as in mitochondrial homeostasis and cellular metabolic programs in a breast cancer cell line. PMID: 24879149
    5. Kaplan-Meier survival analysis showed a significant association between low GABARAPL1 expression and poor prognosis of HCC patients. PMID: 24647565
    6. Data demonstrate that HSP90 interacts and protects GABARAPL1 from its degradation by the proteasome. PMID: 22120110
    7. analysis of specific functions of GABARAPL1 [review] PMID: 21597319
    8. Atg8 interacting motif (AIM) in Stbd1 is necessary for GABARAPL1 binding. PMID: 21893048
    9. Results indicate that the presence of a tryptophan residue in the LIR motif increases the binding affinity of GABARAPL-1/NBR1-LIR complex. PMID: 21620860
    10. Gabarapl1 mRNA expression in breast tumours is a good indicator of the risk of recurrence, specifically in lymph nodes positive patients. PMID: 20197771
    11. GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor PMID: 16431922
    12. GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect. PMID: 19001416
    13. Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. PMID: 19549685

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle membrane; Lipid-anchor. Cytoplasm, cytoskeleton. Endoplasmic reticulum. Golgi apparatus.
  • 蛋白家族:
    ATG8 family
  • 組織特異性:
    Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. In the brain, expression is particularly intense in motone
  • 數據庫鏈接:

    HGNC: 4068

    OMIM: 607420

    KEGG: hsa:23710

    STRING: 9606.ENSP00000266458

    UniGene: Hs.524250



主站蜘蛛池模板: 国产按头口爆吞精在线视频| 女人张开腿让男人桶爽| 国模无码人体一区二区| 秋霞在线观看片无码免费不卡| 亚洲老熟女av一区二区在线播放| 欧美性猛交99久久久久99按摩| 国产亚洲精品一区二区三区| 国模大尺度啪啪| 日本高清va在线播放| 国产做a爰片久久毛片a片美国| 中国极品少妇videossexhd| 女人张开腿让男桶喷水高潮| 国产片精品av在线观看夜色 | 国精产品一区一区三区| 欧美疯狂做受xxxx高潮| 香蕉免费一区二区三区在| 成人网站色52色在线观看| 四虎www成人影院观看| 色偷偷888欧美精品久久久| 成年午夜性影院免费观看| 久久婷婷五月综合色俺也想去| 老司机在线精品视频播放| 奇米影视第四色首页| 在线 无码 中文字幕 强 乱| 亚洲 欧美 影音先锋| 华人少妇被黑人粗大的猛烈进 | 少妇粗大进出白浆嘿嘿视频| 成熟丰满熟妇高潮xxxxx视频 | 亚洲精品综合在线影院| 巨乳美乳一区二区三区| 天天躁日日躁狠狠躁欧美老妇| 日产无码中文字幕av| 国产女主播白浆在线看| 午夜在线观看免费线无码视频| 少妇精品导航| 国产美女久久精品香蕉| 中文字幕被公侵犯的漂亮人妻| 99国产欧美久久久精品蜜芽| 五月丁香啪啪激情综合色九色| 成人影院yy111111| 久久国产精品偷|