在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human GTP-binding protein Rit2 (RIT2)

Recombinant Human GTP-binding protein Rit2 (RIT2)

  • 中文名稱：
    人RIT2重組蛋白
  • 貨號：
    CSB-YP860769HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RIT2重組蛋白
  • 貨號：
    CSB-EP860769HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RIT2重組蛋白
  • 貨號：
    CSB-EP860769HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RIT2重組蛋白
  • 貨號：
    CSB-BP860769HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RIT2重組蛋白
  • 貨號：
    CSB-MP860769HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RIT2
  • Uniprot No.：
  • 別名：
    GTP binding protein Rit2; GTP binding protein Roc2; GTP-binding protein Rit2; Ras like protein expressed in neurons; Ras like without CAAX 2; Ras like without CAAX protein 2; Ras-like protein expressed in neurons; Ras-like without CAAX protein 2; RIBA; Ric (Drosophila) like; Ric like; Ric like, expressed in neurons; RIN; RIT2; RIT2_HUMAN; ROC2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-217
  • 氨基酸序列
    MEVENEASCS PGSASGGSRE YKVVMLGAGG VGKSAMTMQF ISHQFPDYHD PTIEDAYKTQ VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS VTDRQSFQEA AKFKELIFQV RHTYEIPLVL VGNKIDLEQF RQVSTEEGLS LAQEYNCGFF ETSAALRFCI DDAFHGLVRE IRKKESMPSL MEKKLKRKDS LWKKLKGSLK KKRENMT
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator.
  • 基因功能參考文獻：
    1. RIT2 gene was recently introduced as a susceptibility gene in neurological disorders, a group of major problems in human society affecting millions of people worldwide. Several variants, including single nucleotide polymorphisms and CNVs, have been identified and studied in different populations. PMID: 29860660
    2. Significant association of RIT2 Polymorphisms was observed between rs12456492 and two disorders, Parkinson's disease and essential tremor PMID: 26941103
    3. An RIT2 gene variant was found to be a risk factor for autism spectrum disorder in Iranian patients. PMID: 28190241
    4. Findings indicate for the first time, selective advantage for a human-specific allele at an short tandem repeat locus in the human RIT2 core promoter. PMID: 28214997
    5. RIT2 rs12456492 do not increase the risk of developing Parkinson's in Han Chinese. PMID: 27889863
    6. The current meta-analysis suggested that rs12456492 might be associated with increased PD risk in Asian populations, but studies using larger sample sizes and different ethnic populations will be needed to further confirm this association. PMID: 26334395
    7. findings increase the likelihood of association between Parkinson's disease and RIT2 variant in Asian populations PMID: 25146456
    8. performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals PMID: 25559334
    9. Its polymorphism is associated with Parkinson's disease in a Han Chinese population. PMID: 25457028
    10. The data of this study suggested that the RIT2 polymorphisms are associated with Parkinson disease etiology. PMID: 25534083
    11. the G allele, GG and GA genotype of rs12456492(A/G) polymorphism may increase the risk of Parkinson disease. [meta-analysis] PMID: 26188085
    12. failed to replicate the RIT2 rs12456492 variant as a genetic risk factor for Parkinson's disease in our population. PMID: 23635658
    13. These studies confirm the expression of RIT2 in retinal neuronal cells. PMID: 23805044
    14. This meta-analysis identifies a novel Parkinson's disease locus, RIT2, that replicates several previously identified loci on chromosome 18. PMID: 22451204
    15. Rin interacts directly with dopamine transporter DAT in a protein kinase (PK)C-regulated manner and is required for PKC-mediated DAT internalization. PMID: 21957239
    16. Modulates the activation of the Brn-3a regulated egr-1 promoter by the N-terminal domain of Brn-3a PMID: 12934100
    17. Neuron-specific small GTPase Rin is involved in downstream signaling of plexin B3. PMID: 16122393
    18. observations establish Rin as a neuronal specific regulator of neurotrophin signaling, required to couple NGF stimulation to sustain activation of p38 MAP kinase and b-Raf signaling cascades required for neuronal development PMID: 16157584

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cell membrane.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 組織特異性：
    Neuron-specific.
  • 數據庫鏈接：

    HGNC: 10017

    OMIM: 609592

    KEGG: hsa:6014

    STRING: 9606.ENSP00000321805

    UniGene: Hs.464985



主站蜘蛛池模板： 99在线精品国自产拍| 欧美成人h亚洲综合在线观看| 精品无码久久久久久国产| 熟妇好大好深好满好爽| 久久精品女人天堂av| 成人无码免费视频在线播| 九九99精品久久久久久综合| 手机国产乱子伦精品视频| 丰满人妻一区二区三区视频53| 欧美熟妇另类久久久久久多毛| 成人免费视频在线观看| 一个人看免费视频www| 国产成人久久久精品二区三区 | 色又黄又爽18禁免费视频| 欧美饥渴熟妇高潮喷水| 无码专区丰满人妻斩六十路| 国产一卡2卡3卡4卡网站精品| 国产黄大片在线观看画质优化| 老司机午夜免费精品视频| 国产成人无码a区在线| 亚洲色偷偷偷网站色偷一区| 毛片无遮挡高清免费| 精品国精品无码自拍自在线| 亚洲精品无码一二区a片| 国产精华av午夜在线观看| 粗大的内捧猛烈进出视频| 国产精品av免费观看| 国产精品国产三级国av麻豆| 国产精品久久久久久久伊一 | 熟女内射v888av| 亚洲国精产品一二二线| 精品无码中文字幕在线| av性色在线乱叫| 国产精品va无码一区二区| 日本成熟老妇乱| 天天综合色天天综合色h| 久久精品aⅴ无码中文字字幕| 天堂www中文在线资源| 亚洲一区二区三区香蕉| 亚洲综合一区二区三区四区五区| 久久无码中文字幕免费影院|