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  4. RIT2 Antibody

RIT2 Antibody

  • 中文名稱：
    RIT2兔多克隆抗體
  • 貨號：
    CSB-PA860769LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of A549 cells with CSB-PA860769LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA860769LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RIT2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RIT2
  • 別名：
    GTP binding protein Rit2 antibody; GTP binding protein Roc2 antibody; GTP-binding protein Rit2 antibody; Ras like protein expressed in neurons antibody; Ras like without CAAX 2 antibody; Ras like without CAAX protein 2 antibody; Ras-like protein expressed in neurons antibody; Ras-like without CAAX protein 2 antibody; RIBA antibody; Ric (Drosophila) like antibody; Ric like antibody; Ric like, expressed in neurons antibody; RIN antibody; RIT2 antibody; RIT2_HUMAN antibody; ROC2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human GTP-binding protein Rit2 protein (1-150AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，RIT2 Antibody (CSB-PA860769LA01HU)，的標記方式是Non-conjugated。對于RIT2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA860769LB01HU RIT2 Antibody, HRP conjugated ELISA
    FITC CSB-PA860769LC01HU RIT2 Antibody, FITC conjugated
    Biotin CSB-PA860769LD01HU RIT2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator.
  • 基因功能參考文獻：
    1. RIT2 gene was recently introduced as a susceptibility gene in neurological disorders, a group of major problems in human society affecting millions of people worldwide. Several variants, including single nucleotide polymorphisms and CNVs, have been identified and studied in different populations. PMID: 29860660
    2. Significant association of RIT2 Polymorphisms was observed between rs12456492 and two disorders, Parkinson's disease and essential tremor PMID: 26941103
    3. An RIT2 gene variant was found to be a risk factor for autism spectrum disorder in Iranian patients. PMID: 28190241
    4. Findings indicate for the first time, selective advantage for a human-specific allele at an short tandem repeat locus in the human RIT2 core promoter. PMID: 28214997
    5. RIT2 rs12456492 do not increase the risk of developing Parkinson's in Han Chinese. PMID: 27889863
    6. The current meta-analysis suggested that rs12456492 might be associated with increased PD risk in Asian populations, but studies using larger sample sizes and different ethnic populations will be needed to further confirm this association. PMID: 26334395
    7. findings increase the likelihood of association between Parkinson's disease and RIT2 variant in Asian populations PMID: 25146456
    8. performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals PMID: 25559334
    9. Its polymorphism is associated with Parkinson's disease in a Han Chinese population. PMID: 25457028
    10. The data of this study suggested that the RIT2 polymorphisms are associated with Parkinson disease etiology. PMID: 25534083
    11. the G allele, GG and GA genotype of rs12456492(A/G) polymorphism may increase the risk of Parkinson disease. [meta-analysis] PMID: 26188085
    12. failed to replicate the RIT2 rs12456492 variant as a genetic risk factor for Parkinson's disease in our population. PMID: 23635658
    13. These studies confirm the expression of RIT2 in retinal neuronal cells. PMID: 23805044
    14. This meta-analysis identifies a novel Parkinson's disease locus, RIT2, that replicates several previously identified loci on chromosome 18. PMID: 22451204
    15. Rin interacts directly with dopamine transporter DAT in a protein kinase (PK)C-regulated manner and is required for PKC-mediated DAT internalization. PMID: 21957239
    16. Modulates the activation of the Brn-3a regulated egr-1 promoter by the N-terminal domain of Brn-3a PMID: 12934100
    17. Neuron-specific small GTPase Rin is involved in downstream signaling of plexin B3. PMID: 16122393
    18. observations establish Rin as a neuronal specific regulator of neurotrophin signaling, required to couple NGF stimulation to sustain activation of p38 MAP kinase and b-Raf signaling cascades required for neuronal development PMID: 16157584

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  • 亞細胞定位：
    Nucleus. Cell membrane.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 組織特異性：
    Neuron-specific.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10017

    OMIM: 609592

    KEGG: hsa:6014

    STRING: 9606.ENSP00000321805

    UniGene: Hs.464985



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