在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Formin-like protein 2 (FMNL2), partial

Recombinant Human Formin-like protein 2 (FMNL2), partial

  • 中文名稱：
    人FMNL2重組蛋白
  • 貨號：
    CSB-YP822285HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FMNL2重組蛋白
  • 貨號：
    CSB-EP822285HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FMNL2重組蛋白
  • 貨號：
    CSB-EP822285HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FMNL2重組蛋白
  • 貨號：
    CSB-BP822285HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FMNL2重組蛋白
  • 貨號：
    CSB-MP822285HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    FMNL2
  • Uniprot No.：
  • 別名：
    FMNL2; FHOD2; KIAA1902Formin-like protein 2; Formin homology 2 domain-containing protein 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.
  • 基因功能參考文獻：
    1. FMNL2 knockout cells were characterized by impaired filopodia formation similar to depletion of the Rho GTPase Cdc42. PMID: 29579104
    2. Data demonstrate that the FMNL2/COMMD10/p65 NF kappaB axis acts as a critical regulator in the maintenance of metastatic phenotypes in colorectal cancer. PMID: 28817833
    3. Our data proved that RMRP acted as an oncogene LncRNA to promote the expression of KRAS, FMNL2 and SOX9 by inhibiting miR-206 expression in lung cancer. These data suggested that RMRP might serve as a therapeutic target in lung adenocarcinoma PMID: 27906963
    4. FMNL2 is likely to be generally required in melanoma cells for invasion. PMID: 27578625
    5. miR-206 functioned as a tumor suppressor in the progression of colorectal cancer(CRC) by targeting FMNL2 and c-MET. Restoration of miR-206 expression may represent a promising therapeutic approach for targeting malignant CRC. PMID: 26515696
    6. Capping protein and FMNL2 functionally coregulate filament barbed-end assembly. PMID: 26564775
    7. The two interacting FMNL-Cdc42 heterodimers expose six membrane interaction motifs on a convex protein surface, the assembly of which may facilitate actin filament elongation at the leading edge of lamellipodia and filopodia. PMID: 25963737
    8. These data establish a role for FMNL2 in the regulation of beta1-integrin and provide a mechanistic understanding of the function of FMNL2 in cancer invasiveness. PMID: 26256210
    9. MiR-34a was down-regulated in colorectal cancer cells and inversely correlated with FMNL2 and E2F5 expressions. Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5. PMID: 26103003
    10. Rac1-induced actin assembly and subsequent AJ formation critically depends on FMNL2. PMID: 25963818
    11. miR-137, induced by its upstream transcription factor HMGA1, can suppress colorectal cancer cell invasion and metastasis by targeting FMNL2. PMID: 23201162
    12. FMNL2 is a novel elongation factor of actin filaments that constitutes the first Cdc42 effector promoting cell migration and actin polymerization at the tips of lamellipodia. PMID: 22608513
    13. formin-like 2 expression correlated positively with tumor differentiation (P = .046) and vascular invasion (P = .008). Patients whose tumors had lower formin-like 2 expression had shorter overall survival times PMID: 21496865
    14. Findings identify a novel EMT and tumor promoting function for FMNL2, which is involved in TGF-beta-induced EMT and colorectal carcinoma cell invasion via Smad3 effectors, or in collaboration with MAPK/MEK pathway. PMID: 21071512
    15. a novel regulatory and functional interaction between RhoC and FMNL2 for modulating cell shape and invasiveness and provide mechanistic insight into RhoC-specific signalling events. PMID: 20101212
    16. FMNL2 may play an important role in the metastasis of CRC and may be a useful marker for metastasis of CRC. PMID: 18665374

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Formin homology family
  • 數據庫鏈接：

    HGNC: 18267

    OMIM: 616285

    KEGG: hsa:114793

    STRING: 9606.ENSP00000288670

    UniGene: Hs.654630



主站蜘蛛池模板： 中文日产幕无线码6区收藏| 夜夜爽狠狠天天婷婷五月| 免费h动漫无码网站| 丰满少妇被猛烈进入av久久| 中文字幕亚洲欧美在线不卡 | 欧美 国产 综合 欧美 视频| 久久精品成人免费国产| 亚洲狠狠爱综合影院网页| 4444亚洲人成无码网在线观看| 在线天堂中文在线资源网| 掀开奶罩边吃边摸下娇喘视频| 97久久超碰成人精品网站| 国产精品久久久久久久久久红粉| 99国产精品白浆在线观看免费| 国产色在线 | 国产| 女人19水真多免费毛片| 亚洲中文字幕无码中文字| 精品一区二区三区在线观看视频 | 综合久久给合久久狠狠狠97色| 波多野结衣一区二区三区高清av| 一本一本久久a久久综合精品蜜桃| 日韩亚洲国产中文永久| 人妻在线日韩免费视频| 无码人妻丰满熟妇区毛片18 | 囯产精品久久久久久久久久妞妞| 成人亚洲欧美日韩在线观看| 国产深夜男女无套内射| 午夜福利一区二区三区在线观看| 亚洲高清成人aⅴ片| 国产在线精品一品二区| 国产精品爽爽久久久久久| 女人被黑人躁得好爽视频| 中文字幕有码无码人妻在线| 熟妇人妻无码中文字幕| 免费无码av一区二区| 九九线精品视频在线观看| a在线视频v视频| 欧美日韩免费做爰大片人| 午夜福利国产成人a∨在线观看| 亚洲国产欧美在线人成app| 99久久久无码国产精品性|