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  4. Recombinant Human Formin-like protein 2 (FMNL2), partial

Recombinant Human Formin-like protein 2 (FMNL2), partial

  • 中文名稱：
    人FMNL2重組蛋白
  • 貨號：
    CSB-YP822285HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FMNL2重組蛋白
  • 貨號：
    CSB-EP822285HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FMNL2重組蛋白
  • 貨號：
    CSB-EP822285HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FMNL2重組蛋白
  • 貨號：
    CSB-BP822285HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FMNL2重組蛋白
  • 貨號：
    CSB-MP822285HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    FMNL2
  • Uniprot No.：
  • 別名：
    FMNL2; FHOD2; KIAA1902Formin-like protein 2; Formin homology 2 domain-containing protein 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.
  • 基因功能參考文獻：
    1. FMNL2 knockout cells were characterized by impaired filopodia formation similar to depletion of the Rho GTPase Cdc42. PMID: 29579104
    2. Data demonstrate that the FMNL2/COMMD10/p65 NF kappaB axis acts as a critical regulator in the maintenance of metastatic phenotypes in colorectal cancer. PMID: 28817833
    3. Our data proved that RMRP acted as an oncogene LncRNA to promote the expression of KRAS, FMNL2 and SOX9 by inhibiting miR-206 expression in lung cancer. These data suggested that RMRP might serve as a therapeutic target in lung adenocarcinoma PMID: 27906963
    4. FMNL2 is likely to be generally required in melanoma cells for invasion. PMID: 27578625
    5. miR-206 functioned as a tumor suppressor in the progression of colorectal cancer(CRC) by targeting FMNL2 and c-MET. Restoration of miR-206 expression may represent a promising therapeutic approach for targeting malignant CRC. PMID: 26515696
    6. Capping protein and FMNL2 functionally coregulate filament barbed-end assembly. PMID: 26564775
    7. The two interacting FMNL-Cdc42 heterodimers expose six membrane interaction motifs on a convex protein surface, the assembly of which may facilitate actin filament elongation at the leading edge of lamellipodia and filopodia. PMID: 25963737
    8. These data establish a role for FMNL2 in the regulation of beta1-integrin and provide a mechanistic understanding of the function of FMNL2 in cancer invasiveness. PMID: 26256210
    9. MiR-34a was down-regulated in colorectal cancer cells and inversely correlated with FMNL2 and E2F5 expressions. Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5. PMID: 26103003
    10. Rac1-induced actin assembly and subsequent AJ formation critically depends on FMNL2. PMID: 25963818
    11. miR-137, induced by its upstream transcription factor HMGA1, can suppress colorectal cancer cell invasion and metastasis by targeting FMNL2. PMID: 23201162
    12. FMNL2 is a novel elongation factor of actin filaments that constitutes the first Cdc42 effector promoting cell migration and actin polymerization at the tips of lamellipodia. PMID: 22608513
    13. formin-like 2 expression correlated positively with tumor differentiation (P = .046) and vascular invasion (P = .008). Patients whose tumors had lower formin-like 2 expression had shorter overall survival times PMID: 21496865
    14. Findings identify a novel EMT and tumor promoting function for FMNL2, which is involved in TGF-beta-induced EMT and colorectal carcinoma cell invasion via Smad3 effectors, or in collaboration with MAPK/MEK pathway. PMID: 21071512
    15. a novel regulatory and functional interaction between RhoC and FMNL2 for modulating cell shape and invasiveness and provide mechanistic insight into RhoC-specific signalling events. PMID: 20101212
    16. FMNL2 may play an important role in the metastasis of CRC and may be a useful marker for metastasis of CRC. PMID: 18665374

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Formin homology family
  • 數據庫鏈接：

    HGNC: 18267

    OMIM: 616285

    KEGG: hsa:114793

    STRING: 9606.ENSP00000288670

    UniGene: Hs.654630



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