在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Fibroblast growth factor 12 (FGF12)

  • 中文名稱:
    人FGF12重組蛋白
  • 貨號:
    CSB-EP008618HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    FGF12
  • Uniprot No.:
  • 別名:
    EIEE47; FGF-12; Fgf12; FGF12_HUMAN; FGF12B; FHF-1; FHF1; Fibroblast growth factor 12; Fibroblast growth factor 12B; Fibroblast growth factor FGF 12b; Fibroblast growth factor homologous factor 1; Myocyte activating factor; Myocyte-activating factor
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Isoform 2
  • 來源:
    E.coli
  • 分子量:
    47.4kDa
  • 表達區域:
    1-181aa
  • 氨基酸序列
    MESKEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYYVIYSSTLYRQQESGRAWFLGLNKEGQIMKGNRVKKTKPSSHFVPKPIEVCMYREPSLHEIGEKQGRSRKSSGTPTMNGGKVVNQDST
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal GST-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
  • 基因功能參考文獻:
    1. FGF12 has a potential role in ESCC. PMID: 29049013
    2. In this study, the authors observed that rs1460922 of FGF12 was significantly associated with VT and identified that a de novo variation of FGF12 may be an important genetic risk factor for the pathogenesis of VT. PMID: 28775062
    3. FGF12, RBFOX1, and MIR302F could be important in human heterotaxy, because they were noted in multiple cases. Further investigation into genes involved in the NODAL, BMP, and WNT body patterning pathways and into the dosage effects of FGF12, RBFOX1, and MIR302F is warranted. PMID: 27637763
    4. FGF12 strongly induced the quiescent and contractile vascular smooth muscle cell phenotype and directly promoted VSMC lineage differentiation. PMID: 27470512
    5. Results demonstrate that gain-of-function FHF mutations can cause neurologic disorder, and expand the repertoire of genetic causes (FHF1) and mechanisms (altered Nav gating) underlying early-onset epileptic encephalopathies and cerebellar atrophy PMID: 27164707
    6. Nine SNPs of the FGF12 gene were associated with Kashin-Beck disease. PMID: 26290467
    7. Data indicate that SCN5A variant (Nav1.5) p.H1849R affected interaction with fibroblast growth factor homologous factor (FHFs). PMID: 26392562
    8. Q7R-FGF12 is a disease-associated BrS mutation. Moreover, these data suggest for the first time that FHF effects on Na(+) and Ca(2+) channels are separable. PMID: 24096171
    9. VAX1 rs10787760, rs6585429 and rs1871345 polymorphisms may be involved in nonsyndromic cleft lip with or without cleft palate in Brazilian patients, but there is no association with polymorphisms in FGF12, VCL, or CX43 PMID: 23679094
    10. PHOX2B, FGF12 and GAD2 genes are hypermethylated in colorectal neoplastic tissue PMID: 22552777
    11. exogenous FGF12 can play a role in tissues by translocating into cells through the plasma membrane PMID: 21518765
    12. Fibroblast growth factor homologous factor 1B (FHF1B) modulated the cardiac sodium channel Nav1.5. PMID: 12401812
    13. x-ray crystal structure of FHF1b PMID: 12815063
    14. Data describe the biophysical characterization and folding of fibroblast growth factor homologous factor-1b (FHF-1b) in comparison with acidic fibroblast growth factor (FGF-1), and show that FHF-1 is significantly more stable than FGF-1. PMID: 18289114
    15. These findings suggest that FGF12 intracellularly suppresses radiation-induced apoptosis in mast cells independently of IB2. PMID: 18525161

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Epileptic encephalopathy, early infantile, 47 (EIEE47)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Heparin-binding growth factors family
  • 組織特異性:
    Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.
  • 數據庫鏈接:

    HGNC: 3668

    OMIM: 601513

    KEGG: hsa:2257

    STRING: 9606.ENSP00000413496

    UniGene: Hs.390250



主站蜘蛛池模板: 女学生14毛片视频片二毛| 欧美老妇与zozozo交| 欧美日韩国产一区二区三区不卡| 成在人线av无码免费漫画| 狠日狠干日日射| 亚洲国产果冻传媒av在线观看| 色老久久精品偷偷鲁| 亚洲人成网站在线无码| 亚洲色欲色欲综合网站| 毛片无码国产| 女人张开腿让男人桶爽| 欧洲丰满少妇a毛片| 97在线观看播放| 业余 自由 性别 成熟偷窥| 精品国产综合成人亚洲区| 中文字幕无码精品亚洲资源网| 欧美牲交a欧美牲交aⅴ| 十八18禁国产精品www| 欲求不满邻居的爆乳在线播放 | 无码专区手机在线播放| 国产精品无码一区二区三区在 | 国产未发育呦交视频| 亚洲v国产v天堂a无码二区| 1000部拍拍拍18勿入免费视频| 国产精品人妻一码二码尿失禁| 最新国产精品拍自在线观看 | 亚洲国产a∨无码中文777| 欧美激情第1页| 极品人妻被黑人中出种子| 久久99久久99久久综合| 婷婷亚洲综合五月天小说| 国产成人a人亚洲精品无码| aaa午夜级特黄日本大片| 亚洲精品午夜国产va久久成人| 欧美一区二区三区激情| 伊人久久大香线蕉av综合| 精品亚洲国产成人av在线小说| 久久欧美与黑人双交男男| 国产成人无码18禁午夜福利网址| 久久久久人妻一区视色| 欧美颜射内射中出口爆在线|