在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Fibroblast growth factor 12 (FGF12)

  • 中文名稱:
    人FGF12重組蛋白
  • 貨號:
    CSB-EP008618HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    FGF12
  • Uniprot No.:
  • 別名:
    EIEE47; FGF-12; Fgf12; FGF12_HUMAN; FGF12B; FHF-1; FHF1; Fibroblast growth factor 12; Fibroblast growth factor 12B; Fibroblast growth factor FGF 12b; Fibroblast growth factor homologous factor 1; Myocyte activating factor; Myocyte-activating factor
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Isoform 2
  • 來源:
    E.coli
  • 分子量:
    47.4kDa
  • 表達區域:
    1-181aa
  • 氨基酸序列
    MESKEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYYVIYSSTLYRQQESGRAWFLGLNKEGQIMKGNRVKKTKPSSHFVPKPIEVCMYREPSLHEIGEKQGRSRKSSGTPTMNGGKVVNQDST
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal GST-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
  • 基因功能參考文獻:
    1. FGF12 has a potential role in ESCC. PMID: 29049013
    2. In this study, the authors observed that rs1460922 of FGF12 was significantly associated with VT and identified that a de novo variation of FGF12 may be an important genetic risk factor for the pathogenesis of VT. PMID: 28775062
    3. FGF12, RBFOX1, and MIR302F could be important in human heterotaxy, because they were noted in multiple cases. Further investigation into genes involved in the NODAL, BMP, and WNT body patterning pathways and into the dosage effects of FGF12, RBFOX1, and MIR302F is warranted. PMID: 27637763
    4. FGF12 strongly induced the quiescent and contractile vascular smooth muscle cell phenotype and directly promoted VSMC lineage differentiation. PMID: 27470512
    5. Results demonstrate that gain-of-function FHF mutations can cause neurologic disorder, and expand the repertoire of genetic causes (FHF1) and mechanisms (altered Nav gating) underlying early-onset epileptic encephalopathies and cerebellar atrophy PMID: 27164707
    6. Nine SNPs of the FGF12 gene were associated with Kashin-Beck disease. PMID: 26290467
    7. Data indicate that SCN5A variant (Nav1.5) p.H1849R affected interaction with fibroblast growth factor homologous factor (FHFs). PMID: 26392562
    8. Q7R-FGF12 is a disease-associated BrS mutation. Moreover, these data suggest for the first time that FHF effects on Na(+) and Ca(2+) channels are separable. PMID: 24096171
    9. VAX1 rs10787760, rs6585429 and rs1871345 polymorphisms may be involved in nonsyndromic cleft lip with or without cleft palate in Brazilian patients, but there is no association with polymorphisms in FGF12, VCL, or CX43 PMID: 23679094
    10. PHOX2B, FGF12 and GAD2 genes are hypermethylated in colorectal neoplastic tissue PMID: 22552777
    11. exogenous FGF12 can play a role in tissues by translocating into cells through the plasma membrane PMID: 21518765
    12. Fibroblast growth factor homologous factor 1B (FHF1B) modulated the cardiac sodium channel Nav1.5. PMID: 12401812
    13. x-ray crystal structure of FHF1b PMID: 12815063
    14. Data describe the biophysical characterization and folding of fibroblast growth factor homologous factor-1b (FHF-1b) in comparison with acidic fibroblast growth factor (FGF-1), and show that FHF-1 is significantly more stable than FGF-1. PMID: 18289114
    15. These findings suggest that FGF12 intracellularly suppresses radiation-induced apoptosis in mast cells independently of IB2. PMID: 18525161

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Epileptic encephalopathy, early infantile, 47 (EIEE47)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Heparin-binding growth factors family
  • 組織特異性:
    Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.
  • 數據庫鏈接:

    HGNC: 3668

    OMIM: 601513

    KEGG: hsa:2257

    STRING: 9606.ENSP00000413496

    UniGene: Hs.390250



主站蜘蛛池模板: 天天爱天天做天天做天天吃中文 | 亚洲国产精品自在拍在线播放蜜臀| 日本中文一区二区三区亚洲| 国产精品一久久香蕉国产线看观看| 色老久久精品偷偷鲁| 亚洲中文字幕码在线电影| 精品人妻伦一二三区久久aaa片 | 亚洲国产中文在线二区三区免| 久久欧美国产伦子伦精品| 成 人 亚洲 综合天堂| 国产欧美日韩另类在线专区| 乌克兰美女浓毛bbw| 在教室伦流澡到高潮hgl视频| 无套内射极品少妇chinese| 中文字幕热久久久久久久| 小说区亚洲综合第1页| 久久www成人免费直播| 亚洲最大成人av在线天堂网| 久久妇女高潮喷水多| 97国产精东麻豆人妻电影| 国产午夜片无码区在线观看爱情网| 精品国产电影久久九九| 伊人久久大香线蕉亚洲五月天 | 风韵犹存丰满大屁股熟妇视频| 最美女人体内射精一区二区| 亚洲中文字幕无码中文字| 小泽玛莉亚一区二区视频在线| 亚洲精品久久yy5099| 自拍偷自拍亚洲精品第1页| 亚洲自偷自拍熟女另类| 国产成人av免费观看| 国产在线播放精品视频| 国产精品免费久久久久电影| 欧美一区二区三区成人片在线| 久久久久久毛片免费播放| 亚洲日韩乱码中文字幕| 亚洲欧美午夜理论电影在线观看 | 97久久精品人人槡人妻人| 人妻激情偷乱视频一区二区三区| 84pao国产成视频永久免费 | 亚洲无碼网站观看|