在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FGF12 Antibody

  • 中文名稱:
    FGF12兔多克隆抗體
  • 貨號:
    CSB-PA008618ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA008618ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA008618ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FGF12 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FGF12
  • 別名:
    EIEE47 antibody; FGF-12 antibody; Fgf12 antibody; FGF12_HUMAN antibody; FGF12B antibody; FHF-1 antibody; FHF1 antibody; Fibroblast growth factor 12 antibody; Fibroblast growth factor 12B antibody; Fibroblast growth factor FGF 12b antibody; Fibroblast growth factor homologous factor 1 antibody; Myocyte activating factor antibody; Myocyte-activating factor antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Fibroblast growth factor 12 protein (1-181AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
  • 基因功能參考文獻:
    1. FGF12 has a potential role in ESCC. PMID: 29049013
    2. In this study, the authors observed that rs1460922 of FGF12 was significantly associated with VT and identified that a de novo variation of FGF12 may be an important genetic risk factor for the pathogenesis of VT. PMID: 28775062
    3. FGF12, RBFOX1, and MIR302F could be important in human heterotaxy, because they were noted in multiple cases. Further investigation into genes involved in the NODAL, BMP, and WNT body patterning pathways and into the dosage effects of FGF12, RBFOX1, and MIR302F is warranted. PMID: 27637763
    4. FGF12 strongly induced the quiescent and contractile vascular smooth muscle cell phenotype and directly promoted VSMC lineage differentiation. PMID: 27470512
    5. Results demonstrate that gain-of-function FHF mutations can cause neurologic disorder, and expand the repertoire of genetic causes (FHF1) and mechanisms (altered Nav gating) underlying early-onset epileptic encephalopathies and cerebellar atrophy PMID: 27164707
    6. Nine SNPs of the FGF12 gene were associated with Kashin-Beck disease. PMID: 26290467
    7. Data indicate that SCN5A variant (Nav1.5) p.H1849R affected interaction with fibroblast growth factor homologous factor (FHFs). PMID: 26392562
    8. Q7R-FGF12 is a disease-associated BrS mutation. Moreover, these data suggest for the first time that FHF effects on Na(+) and Ca(2+) channels are separable. PMID: 24096171
    9. VAX1 rs10787760, rs6585429 and rs1871345 polymorphisms may be involved in nonsyndromic cleft lip with or without cleft palate in Brazilian patients, but there is no association with polymorphisms in FGF12, VCL, or CX43 PMID: 23679094
    10. PHOX2B, FGF12 and GAD2 genes are hypermethylated in colorectal neoplastic tissue PMID: 22552777
    11. exogenous FGF12 can play a role in tissues by translocating into cells through the plasma membrane PMID: 21518765
    12. Fibroblast growth factor homologous factor 1B (FHF1B) modulated the cardiac sodium channel Nav1.5. PMID: 12401812
    13. x-ray crystal structure of FHF1b PMID: 12815063
    14. Data describe the biophysical characterization and folding of fibroblast growth factor homologous factor-1b (FHF-1b) in comparison with acidic fibroblast growth factor (FGF-1), and show that FHF-1 is significantly more stable than FGF-1. PMID: 18289114
    15. These findings suggest that FGF12 intracellularly suppresses radiation-induced apoptosis in mast cells independently of IB2. PMID: 18525161

    顯示更多

    收起更多

  • 相關疾病:
    Epileptic encephalopathy, early infantile, 47 (EIEE47)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Heparin-binding growth factors family
  • 組織特異性:
    Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.
  • 數據庫鏈接:

    HGNC: 3668

    OMIM: 601513

    KEGG: hsa:2257

    STRING: 9606.ENSP00000413496

    UniGene: Hs.390250



主站蜘蛛池模板: 中文字幕人妻被公上司喝醉506| 亚洲一区二区女搞男| 国产精品黄页免费高清在线观看 | 一区一区三区产品乱码| 国产乱子夫妻xx黑人xyx真爽| 无码精品国产一区二区三区免费| 9久9久女女热精品视频在线观看| 在线播放国产麻豆va剧情| 亚洲日韩久久综合中文字幕| 久久九九av免费精品| 亚洲人成网站在线无码| 成年无码动漫av片在线尤物网站| 国产真实夫妇视频| 99久久国语露脸精品国产 | 四虎永久在线精品免费网站 | 欧美中文亚洲v在线| 欧美精品v国产精品v日韩精品| 色综合久久无码五十路人妻| 亚洲人成电影网站色| 国产午夜无码片在线观看影视| 就去干成人网| 国产看真人毛片爱做a片| 中文天堂最新版在线www| 熟妇人妻不卡中文字幕| 人妻无码第一区二区三区| 精品人妻无码区在线视频| 国产av亚洲aⅴ一区二区| 亚洲中文字幕无码乱线| 国产亚洲精品久久久网站好莱| 久久精品人妻无码一区二区三区v| 52综合精品国产二区无码| 一区二区免费高清观看国产丝瓜| 丰满饥渴老女人hd| 色丁狠狠桃花久久综合网| 精品久久久无码中文字幕天天| 午夜福利一区二区三区在线观看| 色欲天天婬色婬香综合网完整| 欧洲免费一区二区三区视频| 久久久亚洲欧洲日产国码是av| 亚洲国产精品久久久天堂麻豆宅男| 久久久久国产精品人妻电影|