在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FGF12 Antibody

  • 中文名稱:
    FGF12兔多克隆抗體
  • 貨號:
    CSB-PA004992
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 22RV-1 BT474 SHSY5Y cells using FGF-12 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    FGF12
  • 別名:
    EIEE47 antibody; FGF-12 antibody; Fgf12 antibody; FGF12_HUMAN antibody; FGF12B antibody; FHF-1 antibody; FHF1 antibody; Fibroblast growth factor 12 antibody; Fibroblast growth factor 12B antibody; Fibroblast growth factor FGF 12b antibody; Fibroblast growth factor homologous factor 1 antibody; Myocyte activating factor antibody; Myocyte-activating factor antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human FGF-12.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
  • 基因功能參考文獻:
    1. FGF12 has a potential role in ESCC. PMID: 29049013
    2. In this study, the authors observed that rs1460922 of FGF12 was significantly associated with VT and identified that a de novo variation of FGF12 may be an important genetic risk factor for the pathogenesis of VT. PMID: 28775062
    3. FGF12, RBFOX1, and MIR302F could be important in human heterotaxy, because they were noted in multiple cases. Further investigation into genes involved in the NODAL, BMP, and WNT body patterning pathways and into the dosage effects of FGF12, RBFOX1, and MIR302F is warranted. PMID: 27637763
    4. FGF12 strongly induced the quiescent and contractile vascular smooth muscle cell phenotype and directly promoted VSMC lineage differentiation. PMID: 27470512
    5. Results demonstrate that gain-of-function FHF mutations can cause neurologic disorder, and expand the repertoire of genetic causes (FHF1) and mechanisms (altered Nav gating) underlying early-onset epileptic encephalopathies and cerebellar atrophy PMID: 27164707
    6. Nine SNPs of the FGF12 gene were associated with Kashin-Beck disease. PMID: 26290467
    7. Data indicate that SCN5A variant (Nav1.5) p.H1849R affected interaction with fibroblast growth factor homologous factor (FHFs). PMID: 26392562
    8. Q7R-FGF12 is a disease-associated BrS mutation. Moreover, these data suggest for the first time that FHF effects on Na(+) and Ca(2+) channels are separable. PMID: 24096171
    9. VAX1 rs10787760, rs6585429 and rs1871345 polymorphisms may be involved in nonsyndromic cleft lip with or without cleft palate in Brazilian patients, but there is no association with polymorphisms in FGF12, VCL, or CX43 PMID: 23679094
    10. PHOX2B, FGF12 and GAD2 genes are hypermethylated in colorectal neoplastic tissue PMID: 22552777
    11. exogenous FGF12 can play a role in tissues by translocating into cells through the plasma membrane PMID: 21518765
    12. Fibroblast growth factor homologous factor 1B (FHF1B) modulated the cardiac sodium channel Nav1.5. PMID: 12401812
    13. x-ray crystal structure of FHF1b PMID: 12815063
    14. Data describe the biophysical characterization and folding of fibroblast growth factor homologous factor-1b (FHF-1b) in comparison with acidic fibroblast growth factor (FGF-1), and show that FHF-1 is significantly more stable than FGF-1. PMID: 18289114
    15. These findings suggest that FGF12 intracellularly suppresses radiation-induced apoptosis in mast cells independently of IB2. PMID: 18525161

    顯示更多

    收起更多

  • 相關疾病:
    Epileptic encephalopathy, early infantile, 47 (EIEE47)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Heparin-binding growth factors family
  • 組織特異性:
    Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.
  • 數據庫鏈接:

    HGNC: 3668

    OMIM: 601513

    KEGG: hsa:2257

    STRING: 9606.ENSP00000413496

    UniGene: Hs.390250



主站蜘蛛池模板: 综合欧美日韩国产成人| 人妻在卧室被老板疯狂进入| 国产一区二区三区高清在线观看| 成年美女黄网站色大片免费看| 又粗又大又硬毛片免费看| 亚洲大乳高潮日本专区| 亚洲一卡2卡3卡4卡国产| 麻豆专媒体一区二区| 中文字幕韩国三级理论| 午夜精品乱人伦小说区| 欧美成人看片一区二区三区尤物| 精品人妻系列无码人妻免费视频| 高清不卡毛片免费观看| 中文字幕+乱码+中文字幕一区 | 男女边吃奶边做边爱视频| 藏春阁福利视频| 老子午夜精品无码不卡| 成人精品一区二区三区电影免费| 大屁股国产白浆一二区| 少妇人妻偷人激情视频| 中文字幕乱码人妻综合二区三区| 国产高清亚洲精品视bt天堂频 | 99久久婷婷国产一区二区| 国产白嫩护士被弄高潮| 99精品视频九九精品视频| 久久国产精品成人影院| 亚洲伊人丝袜精品久久| 久久www成人看片免费不卡| 日产精品一二三区| 欧美黑人又粗又大又爽免费| 97se亚洲国产综合在线| 国产精品亚洲综合久久系列| 羞涩的丰满人妻40p| 国产精品一区二区av不卡| 国产精品自在在线午夜| 久久五十路丰满熟女中出 | 国产高清国产精品国产专区| 午夜片无码区私人影院| 亚洲中文字幕无码永久| 欧美不卡视频一区发布| 国产精品日韩欧美一区二区三区 |