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  4. Recombinant Human Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A), partial

Recombinant Human Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A), partial

  • 中文名稱：
    人PDE11A重組蛋白
  • 貨號(hào)：
    CSB-YP875726HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    人PDE11A重組蛋白
  • 貨號(hào)：
    CSB-EP875726HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    人PDE11A重組蛋白
  • 貨號(hào)：
    CSB-EP875726HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PDE11A重組蛋白
  • 貨號(hào)：
    CSB-BP875726HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PDE11A重組蛋白
  • 貨號(hào)：
    CSB-MP875726HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PDE11A
  • Uniprot No.：
  • 別名：
    5''-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP phosphodiesterase 11A; cGMP phosphodiesterase 11A; Cyclic nucleotide phosphodiesterase 11A; Dual 3''; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; pde11; PDE11_HUMAN; pde11a; PDE11A1; pde11a2; Phosphodiesterase 11A; PPNAD2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
  • 基因功能參考文獻(xiàn)：
    1. One percent of the Swedish population carries a PDE11A loss-of-function mutation which is associated with elevated BP, abdominal obesity, and risk of ischemic stroke. PMID: 26820475
    2. Testicular germ cell tumors had 55 PDE11A variants: 20 missense (10 new, 9 in transcript variant 4, 1 in transcript variant 3), 4 splice-site, 2 nonsense, 7 synonymous, and 22 intronic. p.F258Y, p.G291R, p.V820M, p.R545X, and p.K568R were only in cases. PMID: 26459559
    3. PDE11A genetic variants may increase predisposition to ACTH-independent macronodular adrenal hyperplasia. PMID: 22996146
    4. found in single nerve trunks in the clitoral stroma PMID: 21697861
    5. Our data suggest that, like in the adrenal cortex and the testicular germ cells, PDE11A-inactivating genetic alterations may play a role in susceptibility to prostate cancer PMID: 20881257
    6. We demonstrate, in a large cohort of Carney Complex patients, a high frequency of PDE11A variants, suggesting that PDE11A is a genetic modifying factor for the development of testicular and adrenal tumors in patients with germline PRKAR1A mutation. PMID: 21047926
    7. PDE11A SNP assocaited with allergic asthma. PMID: 20920776
    8. we detected protein corresponding to PDE11A4, in human prostate, pituitary, heart and liver PMID: 15800651
    9. PDE11A genetic defects may be associated with adrenal pathology in a wider than previously suspected and is associated with adrenal hyperplasia and adenomas. PMID: 17178847
    10. Variants in PDE11A are not associated with citalopram response in patient with depression. PMID: 18043711
    11. N-terminal modifications strongly affect cGMP regulation of hPDE11A4 PMID: 18312413
    12. PDE11A is expressed widely in adrenal cortex. Its expression appears to be increased in PPNAD but varies widely among other adrenocortical tumors. PMID: 18491255
    13. PDE11A sequence defects predispose to a variety of lesions (beyond micronodular adrenocortical hyperplasia). PMID: 18559625
    14. PDE11A, is unlikely to play an important role in antidepressant outcome in this sample PMID: 19214142
    15. PDE11A-inactivating sequence variants may modify the risk of familial and bilateral testicular germ cell tumors. PMID: 19549888
    16. Immunohistochemistry revealed PDE11A expression higher in somatotropinomas than in normal somatotrophs, without significant difference between tumors with or without PDE11A variants. PMID: 19671705

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  • 相關(guān)疾病：
    Primary pigmented nodular adrenocortical disease 2 (PPNAD2)
  • 亞細(xì)胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family
  • 組織特異性：
    Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is ex
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8773

    OMIM: 604961

    KEGG: hsa:50940

    STRING: 9606.ENSP00000286063

    UniGene: Hs.570273



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